KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
NKTR
Full Name:
NK-tumor recognition protein
Alias:
Natural killer triggering receptor; Natural killer-tumor recognition sequence; Natural-killer cells cyclophilin-related protein; NK-TR protein; P104
Type:
Cell surface
Mass (Da):
165677
Number AA:
1462
UniProt ID:
P30414
International Prot ID:
IPI00295022
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0016018
GO:0003755
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T52
G
E
K
G
L
G
K
T
T
G
K
K
L
C
Y
Site 2
Y59
T
T
G
K
K
L
C
Y
K
G
S
T
F
H
R
Site 3
S62
K
K
L
C
Y
K
G
S
T
F
H
R
V
V
K
Site 4
T63
K
L
C
Y
K
G
S
T
F
H
R
V
V
K
N
Site 5
S79
M
I
Q
G
G
D
F
S
E
G
N
G
K
G
G
Site 6
S88
G
N
G
K
G
G
E
S
I
Y
G
G
Y
F
K
Site 7
Y90
G
K
G
G
E
S
I
Y
G
G
Y
F
K
D
E
Site 8
Y93
G
E
S
I
Y
G
G
Y
F
K
D
E
N
F
I
Site 9
S110
H
D
R
A
F
L
L
S
M
A
N
R
G
K
H
Site 10
S121
R
G
K
H
T
N
G
S
Q
F
F
I
T
T
K
Site 11
T126
N
G
S
Q
F
F
I
T
T
K
P
A
P
H
L
Site 12
T158
E
Q
I
E
N
L
K
T
D
A
A
S
R
P
Y
Site 13
S162
N
L
K
T
D
A
A
S
R
P
Y
A
D
V
R
Site 14
Y165
T
D
A
A
S
R
P
Y
A
D
V
R
V
I
D
Site 15
S195
K
R
K
K
P
T
H
S
E
G
S
D
S
S
S
Site 16
S198
K
P
T
H
S
E
G
S
D
S
S
S
N
S
S
Site 17
S200
T
H
S
E
G
S
D
S
S
S
N
S
S
S
S
Site 18
S201
H
S
E
G
S
D
S
S
S
N
S
S
S
S
S
Site 19
S202
S
E
G
S
D
S
S
S
N
S
S
S
S
S
E
Site 20
S204
G
S
D
S
S
S
N
S
S
S
S
S
E
S
S
Site 21
S205
S
D
S
S
S
N
S
S
S
S
S
E
S
S
S
Site 22
S206
D
S
S
S
N
S
S
S
S
S
E
S
S
S
E
Site 23
S207
S
S
S
N
S
S
S
S
S
E
S
S
S
E
S
Site 24
S208
S
S
N
S
S
S
S
S
E
S
S
S
E
S
E
Site 25
S210
N
S
S
S
S
S
E
S
S
S
E
S
E
L
E
Site 26
S211
S
S
S
S
S
E
S
S
S
E
S
E
L
E
H
Site 27
S212
S
S
S
S
E
S
S
S
E
S
E
L
E
H
E
Site 28
S214
S
S
E
S
S
S
E
S
E
L
E
H
E
R
S
Site 29
S221
S
E
L
E
H
E
R
S
R
R
R
K
H
K
R
Site 30
S235
R
R
P
K
V
K
R
S
K
K
R
R
K
E
A
Site 31
S243
K
K
R
R
K
E
A
S
S
S
E
E
P
R
N
Site 32
S244
K
R
R
K
E
A
S
S
S
E
E
P
R
N
K
Site 33
S245
R
R
K
E
A
S
S
S
E
E
P
R
N
K
H
Site 34
S260
A
M
N
P
K
G
H
S
E
R
S
D
T
N
E
Site 35
S263
P
K
G
H
S
E
R
S
D
T
N
E
K
R
S
Site 36
T265
G
H
S
E
R
S
D
T
N
E
K
R
S
V
D
Site 37
S270
S
D
T
N
E
K
R
S
V
D
S
S
A
K
R
Site 38
S273
N
E
K
R
S
V
D
S
S
A
K
R
E
K
P
Site 39
S274
E
K
R
S
V
D
S
S
A
K
R
E
K
P
V
Site 40
T305
R
R
D
M
P
V
V
T
A
E
P
E
P
K
I
Site 41
S320
P
D
V
A
P
I
V
S
D
Q
K
P
S
V
S
Site 42
S325
I
V
S
D
Q
K
P
S
V
S
K
S
G
R
K
Site 43
S327
S
D
Q
K
P
S
V
S
K
S
G
R
K
I
K
Site 44
S329
Q
K
P
S
V
S
K
S
G
R
K
I
K
G
R
Site 45
T338
R
K
I
K
G
R
G
T
I
R
Y
H
T
P
P
Site 46
Y341
K
G
R
G
T
I
R
Y
H
T
P
P
R
S
R
Site 47
T343
R
G
T
I
R
Y
H
T
P
P
R
S
R
S
C
Site 48
S347
R
Y
H
T
P
P
R
S
R
S
C
S
E
S
D
Site 49
S349
H
T
P
P
R
S
R
S
C
S
E
S
D
D
D
Site 50
S351
P
P
R
S
R
S
C
S
E
S
D
D
D
D
S
Site 51
S353
R
S
R
S
C
S
E
S
D
D
D
D
S
S
E
Site 52
S358
S
E
S
D
D
D
D
S
S
E
T
P
P
H
W
Site 53
S359
E
S
D
D
D
D
S
S
E
T
P
P
H
W
K
Site 54
T361
D
D
D
D
S
S
E
T
P
P
H
W
K
E
E
Site 55
Y375
E
M
Q
R
L
R
A
Y
R
P
P
S
G
E
K
Site 56
S379
L
R
A
Y
R
P
P
S
G
E
K
W
S
K
G
Site 57
S384
P
P
S
G
E
K
W
S
K
G
D
K
L
S
D
Site 58
S390
W
S
K
G
D
K
L
S
D
P
C
S
S
R
W
Site 59
S394
D
K
L
S
D
P
C
S
S
R
W
D
E
R
S
Site 60
S401
S
S
R
W
D
E
R
S
L
S
Q
R
S
R
S
Site 61
S403
R
W
D
E
R
S
L
S
Q
R
S
R
S
W
S
Site 62
S406
E
R
S
L
S
Q
R
S
R
S
W
S
Y
N
G
Site 63
S408
S
L
S
Q
R
S
R
S
W
S
Y
N
G
Y
Y
Site 64
S410
S
Q
R
S
R
S
W
S
Y
N
G
Y
Y
S
D
Site 65
Y411
Q
R
S
R
S
W
S
Y
N
G
Y
Y
S
D
L
Site 66
Y414
R
S
W
S
Y
N
G
Y
Y
S
D
L
S
T
A
Site 67
Y415
S
W
S
Y
N
G
Y
Y
S
D
L
S
T
A
R
Site 68
S416
W
S
Y
N
G
Y
Y
S
D
L
S
T
A
R
H
Site 69
S419
N
G
Y
Y
S
D
L
S
T
A
R
H
S
G
H
Site 70
T420
G
Y
Y
S
D
L
S
T
A
R
H
S
G
H
H
Site 71
S424
D
L
S
T
A
R
H
S
G
H
H
K
K
R
R
Site 72
T454
H
C
R
R
H
K
Q
T
K
K
R
R
I
L
I
Site 73
S463
K
R
R
I
L
I
P
S
D
I
E
S
S
K
S
Site 74
S467
L
I
P
S
D
I
E
S
S
K
S
S
T
R
R
Site 75
S468
I
P
S
D
I
E
S
S
K
S
S
T
R
R
M
Site 76
S470
S
D
I
E
S
S
K
S
S
T
R
R
M
K
S
Site 77
S471
D
I
E
S
S
K
S
S
T
R
R
M
K
S
S
Site 78
T472
I
E
S
S
K
S
S
T
R
R
M
K
S
S
C
Site 79
S477
S
S
T
R
R
M
K
S
S
C
D
R
E
R
S
Site 80
S478
S
T
R
R
M
K
S
S
C
D
R
E
R
S
S
Site 81
S484
S
S
C
D
R
E
R
S
S
R
S
S
S
L
S
Site 82
S485
S
C
D
R
E
R
S
S
R
S
S
S
L
S
S
Site 83
S487
D
R
E
R
S
S
R
S
S
S
L
S
S
H
H
Site 84
S488
R
E
R
S
S
R
S
S
S
L
S
S
H
H
S
Site 85
S489
E
R
S
S
R
S
S
S
L
S
S
H
H
S
S
Site 86
S491
S
S
R
S
S
S
L
S
S
H
H
S
S
K
R
Site 87
S492
S
R
S
S
S
L
S
S
H
H
S
S
K
R
D
Site 88
S495
S
S
L
S
S
H
H
S
S
K
R
D
W
S
K
Site 89
S496
S
L
S
S
H
H
S
S
K
R
D
W
S
K
S
Site 90
S501
H
S
S
K
R
D
W
S
K
S
D
K
D
V
Q
Site 91
S503
S
K
R
D
W
S
K
S
D
K
D
V
Q
S
S
Site 92
S509
K
S
D
K
D
V
Q
S
S
L
T
H
S
S
R
Site 93
S510
S
D
K
D
V
Q
S
S
L
T
H
S
S
R
D
Site 94
T512
K
D
V
Q
S
S
L
T
H
S
S
R
D
S
Y
Site 95
S514
V
Q
S
S
L
T
H
S
S
R
D
S
Y
R
S
Site 96
S515
Q
S
S
L
T
H
S
S
R
D
S
Y
R
S
K
Site 97
S518
L
T
H
S
S
R
D
S
Y
R
S
K
S
H
S
Site 98
Y519
T
H
S
S
R
D
S
Y
R
S
K
S
H
S
Q
Site 99
S521
S
S
R
D
S
Y
R
S
K
S
H
S
Q
S
Y
Site 100
S523
R
D
S
Y
R
S
K
S
H
S
Q
S
Y
S
R
Site 101
S525
S
Y
R
S
K
S
H
S
Q
S
Y
S
R
G
S
Site 102
S527
R
S
K
S
H
S
Q
S
Y
S
R
G
S
S
R
Site 103
Y528
S
K
S
H
S
Q
S
Y
S
R
G
S
S
R
S
Site 104
S529
K
S
H
S
Q
S
Y
S
R
G
S
S
R
S
R
Site 105
S532
S
Q
S
Y
S
R
G
S
S
R
S
R
T
A
S
Site 106
S533
Q
S
Y
S
R
G
S
S
R
S
R
T
A
S
K
Site 107
S535
Y
S
R
G
S
S
R
S
R
T
A
S
K
S
S
Site 108
T537
R
G
S
S
R
S
R
T
A
S
K
S
S
S
H
Site 109
S539
S
S
R
S
R
T
A
S
K
S
S
S
H
S
R
Site 110
S541
R
S
R
T
A
S
K
S
S
S
H
S
R
S
R
Site 111
S542
S
R
T
A
S
K
S
S
S
H
S
R
S
R
S
Site 112
S543
R
T
A
S
K
S
S
S
H
S
R
S
R
S
K
Site 113
S545
A
S
K
S
S
S
H
S
R
S
R
S
K
S
R
Site 114
S547
K
S
S
S
H
S
R
S
R
S
K
S
R
S
S
Site 115
S549
S
S
H
S
R
S
R
S
K
S
R
S
S
S
K
Site 116
S551
H
S
R
S
R
S
K
S
R
S
S
S
K
S
G
Site 117
S553
R
S
R
S
K
S
R
S
S
S
K
S
G
H
R
Site 118
S554
S
R
S
K
S
R
S
S
S
K
S
G
H
R
K
Site 119
S555
R
S
K
S
R
S
S
S
K
S
G
H
R
K
R
Site 120
S557
K
S
R
S
S
S
K
S
G
H
R
K
R
A
S
Site 121
S564
S
G
H
R
K
R
A
S
K
S
P
R
K
T
A
Site 122
S566
H
R
K
R
A
S
K
S
P
R
K
T
A
S
Q
Site 123
T570
A
S
K
S
P
R
K
T
A
S
Q
L
S
E
N
Site 124
S572
K
S
P
R
K
T
A
S
Q
L
S
E
N
K
P
Site 125
S575
R
K
T
A
S
Q
L
S
E
N
K
P
V
K
T
Site 126
T588
K
T
E
P
L
R
A
T
M
A
Q
N
E
N
V
Site 127
S611
N
I
P
V
I
P
L
S
D
S
P
P
P
S
R
Site 128
S613
P
V
I
P
L
S
D
S
P
P
P
S
R
W
K
Site 129
S617
L
S
D
S
P
P
P
S
R
W
K
P
G
Q
K
Site 130
S629
G
Q
K
P
W
K
P
S
Y
E
R
I
Q
E
M
Site 131
Y630
Q
K
P
W
K
P
S
Y
E
R
I
Q
E
M
K
Site 132
S651
L
P
I
Q
S
T
Y
S
L
A
N
I
K
E
T
Site 133
T658
S
L
A
N
I
K
E
T
G
S
S
S
S
Y
H
Site 134
S661
N
I
K
E
T
G
S
S
S
S
Y
H
K
R
E
Site 135
S662
I
K
E
T
G
S
S
S
S
Y
H
K
R
E
K
Site 136
Y664
E
T
G
S
S
S
S
Y
H
K
R
E
K
N
S
Site 137
S671
Y
H
K
R
E
K
N
S
E
S
D
Q
S
T
Y
Site 138
S673
K
R
E
K
N
S
E
S
D
Q
S
T
Y
S
K
Site 139
S676
K
N
S
E
S
D
Q
S
T
Y
S
K
Y
S
D
Site 140
T677
N
S
E
S
D
Q
S
T
Y
S
K
Y
S
D
R
Site 141
Y678
S
E
S
D
Q
S
T
Y
S
K
Y
S
D
R
S
Site 142
S679
E
S
D
Q
S
T
Y
S
K
Y
S
D
R
S
S
Site 143
Y681
D
Q
S
T
Y
S
K
Y
S
D
R
S
S
E
S
Site 144
S682
Q
S
T
Y
S
K
Y
S
D
R
S
S
E
S
S
Site 145
S685
Y
S
K
Y
S
D
R
S
S
E
S
S
P
R
S
Site 146
S686
S
K
Y
S
D
R
S
S
E
S
S
P
R
S
R
Site 147
S688
Y
S
D
R
S
S
E
S
S
P
R
S
R
S
R
Site 148
S689
S
D
R
S
S
E
S
S
P
R
S
R
S
R
S
Site 149
S692
S
S
E
S
S
P
R
S
R
S
R
S
S
R
S
Site 150
S694
E
S
S
P
R
S
R
S
R
S
S
R
S
R
S
Site 151
S696
S
P
R
S
R
S
R
S
S
R
S
R
S
Y
S
Site 152
S697
P
R
S
R
S
R
S
S
R
S
R
S
Y
S
R
Site 153
S699
S
R
S
R
S
S
R
S
R
S
Y
S
R
S
Y
Site 154
S701
S
R
S
S
R
S
R
S
Y
S
R
S
Y
T
R
Site 155
Y702
R
S
S
R
S
R
S
Y
S
R
S
Y
T
R
S
Site 156
S703
S
S
R
S
R
S
Y
S
R
S
Y
T
R
S
R
Site 157
S705
R
S
R
S
Y
S
R
S
Y
T
R
S
R
S
L
Site 158
Y706
S
R
S
Y
S
R
S
Y
T
R
S
R
S
L
A
Site 159
T707
R
S
Y
S
R
S
Y
T
R
S
R
S
L
A
S
Site 160
S709
Y
S
R
S
Y
T
R
S
R
S
L
A
S
S
H
Site 161
S711
R
S
Y
T
R
S
R
S
L
A
S
S
H
S
R
Site 162
S714
T
R
S
R
S
L
A
S
S
H
S
R
S
R
S
Site 163
S715
R
S
R
S
L
A
S
S
H
S
R
S
R
S
P
Site 164
S717
R
S
L
A
S
S
H
S
R
S
R
S
P
S
S
Site 165
S719
L
A
S
S
H
S
R
S
R
S
P
S
S
R
S
Site 166
S721
S
S
H
S
R
S
R
S
P
S
S
R
S
H
S
Site 167
S723
H
S
R
S
R
S
P
S
S
R
S
H
S
R
N
Site 168
S724
S
R
S
R
S
P
S
S
R
S
H
S
R
N
K
Site 169
S726
S
R
S
P
S
S
R
S
H
S
R
N
K
Y
S
Site 170
S728
S
P
S
S
R
S
H
S
R
N
K
Y
S
D
H
Site 171
Y732
R
S
H
S
R
N
K
Y
S
D
H
S
Q
C
S
Site 172
S733
S
H
S
R
N
K
Y
S
D
H
S
Q
C
S
R
Site 173
S736
R
N
K
Y
S
D
H
S
Q
C
S
R
S
S
S
Site 174
S739
Y
S
D
H
S
Q
C
S
R
S
S
S
Y
T
S
Site 175
S741
D
H
S
Q
C
S
R
S
S
S
Y
T
S
I
S
Site 176
S742
H
S
Q
C
S
R
S
S
S
Y
T
S
I
S
S
Site 177
S743
S
Q
C
S
R
S
S
S
Y
T
S
I
S
S
D
Site 178
Y744
Q
C
S
R
S
S
S
Y
T
S
I
S
S
D
D
Site 179
T745
C
S
R
S
S
S
Y
T
S
I
S
S
D
D
G
Site 180
S746
S
R
S
S
S
Y
T
S
I
S
S
D
D
G
R
Site 181
S748
S
S
S
Y
T
S
I
S
S
D
D
G
R
R
A
Site 182
S749
S
S
Y
T
S
I
S
S
D
D
G
R
R
A
K
Site 183
S761
R
A
K
R
R
L
R
S
S
G
K
K
N
S
V
Site 184
S762
A
K
R
R
L
R
S
S
G
K
K
N
S
V
S
Site 185
S767
R
S
S
G
K
K
N
S
V
S
H
K
K
H
S
Site 186
S769
S
G
K
K
N
S
V
S
H
K
K
H
S
S
S
Site 187
S774
S
V
S
H
K
K
H
S
S
S
S
E
K
T
L
Site 188
S775
V
S
H
K
K
H
S
S
S
S
E
K
T
L
H
Site 189
S776
S
H
K
K
H
S
S
S
S
E
K
T
L
H
S
Site 190
S777
H
K
K
H
S
S
S
S
E
K
T
L
H
S
K
Site 191
T780
H
S
S
S
S
E
K
T
L
H
S
K
Y
V
K
Site 192
Y785
E
K
T
L
H
S
K
Y
V
K
G
R
D
R
S
Site 193
S792
Y
V
K
G
R
D
R
S
S
C
V
R
K
Y
S
Site 194
S793
V
K
G
R
D
R
S
S
C
V
R
K
Y
S
E
Site 195
Y798
R
S
S
C
V
R
K
Y
S
E
S
R
S
S
L
Site 196
S799
S
S
C
V
R
K
Y
S
E
S
R
S
S
L
D
Site 197
S801
C
V
R
K
Y
S
E
S
R
S
S
L
D
Y
S
Site 198
S803
R
K
Y
S
E
S
R
S
S
L
D
Y
S
S
D
Site 199
S804
K
Y
S
E
S
R
S
S
L
D
Y
S
S
D
S
Site 200
Y807
E
S
R
S
S
L
D
Y
S
S
D
S
E
Q
S
Site 201
S808
S
R
S
S
L
D
Y
S
S
D
S
E
Q
S
S
Site 202
S809
R
S
S
L
D
Y
S
S
D
S
E
Q
S
S
V
Site 203
S811
S
L
D
Y
S
S
D
S
E
Q
S
S
V
Q
A
Site 204
S815
S
S
D
S
E
Q
S
S
V
Q
A
T
Q
S
A
Site 205
T819
E
Q
S
S
V
Q
A
T
Q
S
A
Q
E
K
E
Site 206
S821
S
S
V
Q
A
T
Q
S
A
Q
E
K
E
K
Q
Site 207
S847
K
N
R
G
E
E
K
S
K
S
E
R
E
C
P
Site 208
S849
R
G
E
E
K
S
K
S
E
R
E
C
P
H
S
Site 209
S856
S
E
R
E
C
P
H
S
K
K
R
T
L
K
E
Site 210
T860
C
P
H
S
K
K
R
T
L
K
E
N
L
S
D
Site 211
S866
R
T
L
K
E
N
L
S
D
H
L
R
N
G
S
Site 212
S873
S
D
H
L
R
N
G
S
K
P
K
R
K
N
Y
Site 213
Y880
S
K
P
K
R
K
N
Y
A
G
S
K
W
D
S
Site 214
S883
K
R
K
N
Y
A
G
S
K
W
D
S
E
S
N
Site 215
S887
Y
A
G
S
K
W
D
S
E
S
N
S
E
R
D
Site 216
S889
G
S
K
W
D
S
E
S
N
S
E
R
D
V
T
Site 217
S891
K
W
D
S
E
S
N
S
E
R
D
V
T
K
N
Site 218
T896
S
N
S
E
R
D
V
T
K
N
S
K
N
D
S
Site 219
S899
E
R
D
V
T
K
N
S
K
N
D
S
H
P
S
Site 220
S903
T
K
N
S
K
N
D
S
H
P
S
S
D
K
E
Site 221
S907
K
N
D
S
H
P
S
S
D
K
E
E
G
E
A
Site 222
T915
D
K
E
E
G
E
A
T
S
D
S
E
S
E
V
Site 223
S916
K
E
E
G
E
A
T
S
D
S
E
S
E
V
S
Site 224
S918
E
G
E
A
T
S
D
S
E
S
E
V
S
E
I
Site 225
S920
E
A
T
S
D
S
E
S
E
V
S
E
I
H
I
Site 226
S923
S
D
S
E
S
E
V
S
E
I
H
I
K
V
K
Site 227
T933
H
I
K
V
K
P
T
T
K
S
S
T
N
T
S
Site 228
S935
K
V
K
P
T
T
K
S
S
T
N
T
S
L
P
Site 229
S936
V
K
P
T
T
K
S
S
T
N
T
S
L
P
D
Site 230
S940
T
K
S
S
T
N
T
S
L
P
D
D
N
G
A
Site 231
S950
D
D
N
G
A
W
K
S
S
K
Q
R
T
S
T
Site 232
S951
D
N
G
A
W
K
S
S
K
Q
R
T
S
T
S
Site 233
T955
W
K
S
S
K
Q
R
T
S
T
S
D
S
E
G
Site 234
S956
K
S
S
K
Q
R
T
S
T
S
D
S
E
G
S
Site 235
T957
S
S
K
Q
R
T
S
T
S
D
S
E
G
S
C
Site 236
S958
S
K
Q
R
T
S
T
S
D
S
E
G
S
C
S
Site 237
S960
Q
R
T
S
T
S
D
S
E
G
S
C
S
N
S
Site 238
S963
S
T
S
D
S
E
G
S
C
S
N
S
E
N
N
Site 239
S965
S
D
S
E
G
S
C
S
N
S
E
N
N
R
G
Site 240
S967
S
E
G
S
C
S
N
S
E
N
N
R
G
K
P
Site 241
T990
E
N
L
K
R
E
H
T
K
K
V
K
E
K
L
Site 242
S1039
D
K
Q
V
T
Q
E
S
K
E
K
K
V
S
E
Site 243
S1045
E
S
K
E
K
K
V
S
E
N
N
E
T
I
K
Site 244
T1050
K
V
S
E
N
N
E
T
I
K
D
N
I
L
K
Site 245
T1058
I
K
D
N
I
L
K
T
E
K
S
S
E
E
D
Site 246
S1061
N
I
L
K
T
E
K
S
S
E
E
D
L
S
G
Site 247
S1067
K
S
S
E
E
D
L
S
G
K
H
D
T
V
T
Site 248
T1072
D
L
S
G
K
H
D
T
V
T
V
S
S
D
L
Site 249
T1074
S
G
K
H
D
T
V
T
V
S
S
D
L
D
Q
Site 250
S1076
K
H
D
T
V
T
V
S
S
D
L
D
Q
F
T
Site 251
S1077
H
D
T
V
T
V
S
S
D
L
D
Q
F
T
K
Site 252
T1083
S
S
D
L
D
Q
F
T
K
D
D
S
K
L
S
Site 253
S1087
D
Q
F
T
K
D
D
S
K
L
S
I
S
P
T
Site 254
S1090
T
K
D
D
S
K
L
S
I
S
P
T
A
L
N
Site 255
S1092
D
D
S
K
L
S
I
S
P
T
A
L
N
T
E
Site 256
T1094
S
K
L
S
I
S
P
T
A
L
N
T
E
E
N
Site 257
S1114
N
I
Q
H
V
E
E
S
V
P
N
G
V
E
D
Site 258
T1133
D
D
N
M
E
I
C
T
P
D
R
S
S
P
A
Site 259
S1138
I
C
T
P
D
R
S
S
P
A
K
V
E
E
T
Site 260
T1145
S
P
A
K
V
E
E
T
S
P
L
G
N
A
R
Site 261
S1146
P
A
K
V
E
E
T
S
P
L
G
N
A
R
L
Site 262
T1155
L
G
N
A
R
L
D
T
P
D
I
N
I
V
L
Site 263
T1168
V
L
K
Q
D
M
A
T
E
H
P
Q
A
E
V
Site 264
S1181
E
V
V
K
Q
E
S
S
M
S
E
S
K
V
L
Site 265
S1183
V
K
Q
E
S
S
M
S
E
S
K
V
L
G
E
Site 266
S1185
Q
E
S
S
M
S
E
S
K
V
L
G
E
V
G
Site 267
S1196
G
E
V
G
K
Q
D
S
S
S
A
S
L
A
S
Site 268
S1197
E
V
G
K
Q
D
S
S
S
A
S
L
A
S
A
Site 269
S1198
V
G
K
Q
D
S
S
S
A
S
L
A
S
A
G
Site 270
S1200
K
Q
D
S
S
S
A
S
L
A
S
A
G
E
S
Site 271
S1203
S
S
S
A
S
L
A
S
A
G
E
S
T
G
K
Site 272
S1207
S
L
A
S
A
G
E
S
T
G
K
K
E
V
A
Site 273
S1217
K
K
E
V
A
E
K
S
Q
I
N
L
I
D
K
Site 274
S1268
G
L
R
I
E
I
K
S
K
N
K
V
R
P
G
Site 275
S1276
K
N
K
V
R
P
G
S
L
F
D
E
V
R
K
Site 276
T1284
L
F
D
E
V
R
K
T
A
R
L
N
R
R
P
Site 277
S1296
R
R
P
R
N
Q
E
S
S
S
D
E
Q
T
P
Site 278
S1297
R
P
R
N
Q
E
S
S
S
D
E
Q
T
P
S
Site 279
S1298
P
R
N
Q
E
S
S
S
D
E
Q
T
P
S
R
Site 280
T1302
E
S
S
S
D
E
Q
T
P
S
R
D
D
D
S
Site 281
S1304
S
S
D
E
Q
T
P
S
R
D
D
D
S
Q
S
Site 282
S1309
T
P
S
R
D
D
D
S
Q
S
R
S
P
S
R
Site 283
S1311
S
R
D
D
D
S
Q
S
R
S
P
S
R
S
R
Site 284
S1313
D
D
D
S
Q
S
R
S
P
S
R
S
R
S
K
Site 285
S1315
D
S
Q
S
R
S
P
S
R
S
R
S
K
S
E
Site 286
S1317
Q
S
R
S
P
S
R
S
R
S
K
S
E
T
K
Site 287
S1319
R
S
P
S
R
S
R
S
K
S
E
T
K
S
R
Site 288
S1321
P
S
R
S
R
S
K
S
E
T
K
S
R
H
R
Site 289
T1323
R
S
R
S
K
S
E
T
K
S
R
H
R
T
R
Site 290
S1325
R
S
K
S
E
T
K
S
R
H
R
T
R
S
V
Site 291
T1329
E
T
K
S
R
H
R
T
R
S
V
S
Y
S
H
Site 292
S1331
K
S
R
H
R
T
R
S
V
S
Y
S
H
S
R
Site 293
S1333
R
H
R
T
R
S
V
S
Y
S
H
S
R
S
R
Site 294
S1335
R
T
R
S
V
S
Y
S
H
S
R
S
R
S
R
Site 295
S1337
R
S
V
S
Y
S
H
S
R
S
R
S
R
S
S
Site 296
S1339
V
S
Y
S
H
S
R
S
R
S
R
S
S
T
S
Site 297
S1341
Y
S
H
S
R
S
R
S
R
S
S
T
S
S
Y
Site 298
S1343
H
S
R
S
R
S
R
S
S
T
S
S
Y
R
S
Site 299
S1344
S
R
S
R
S
R
S
S
T
S
S
Y
R
S
R
Site 300
T1345
R
S
R
S
R
S
S
T
S
S
Y
R
S
R
S
Site 301
S1346
S
R
S
R
S
S
T
S
S
Y
R
S
R
S
Y
Site 302
S1347
R
S
R
S
S
T
S
S
Y
R
S
R
S
Y
S
Site 303
Y1348
S
R
S
S
T
S
S
Y
R
S
R
S
Y
S
R
Site 304
S1350
S
S
T
S
S
Y
R
S
R
S
Y
S
R
S
R
Site 305
S1352
T
S
S
Y
R
S
R
S
Y
S
R
S
R
S
R
Site 306
Y1353
S
S
Y
R
S
R
S
Y
S
R
S
R
S
R
G
Site 307
S1354
S
Y
R
S
R
S
Y
S
R
S
R
S
R
G
W
Site 308
S1356
R
S
R
S
Y
S
R
S
R
S
R
G
W
Y
S
Site 309
S1358
R
S
Y
S
R
S
R
S
R
G
W
Y
S
R
G
Site 310
Y1362
R
S
R
S
R
G
W
Y
S
R
G
R
T
R
S
Site 311
S1363
S
R
S
R
G
W
Y
S
R
G
R
T
R
S
R
Site 312
T1367
G
W
Y
S
R
G
R
T
R
S
R
S
S
S
Y
Site 313
S1369
Y
S
R
G
R
T
R
S
R
S
S
S
Y
R
S
Site 314
S1371
R
G
R
T
R
S
R
S
S
S
Y
R
S
Y
K
Site 315
S1372
G
R
T
R
S
R
S
S
S
Y
R
S
Y
K
S
Site 316
S1373
R
T
R
S
R
S
S
S
Y
R
S
Y
K
S
H
Site 317
S1376
S
R
S
S
S
Y
R
S
Y
K
S
H
R
T
S
Site 318
Y1377
R
S
S
S
Y
R
S
Y
K
S
H
R
T
S
S
Site 319
S1379
S
S
Y
R
S
Y
K
S
H
R
T
S
S
R
S
Site 320
T1382
R
S
Y
K
S
H
R
T
S
S
R
S
R
S
R
Site 321
S1383
S
Y
K
S
H
R
T
S
S
R
S
R
S
R
S
Site 322
S1384
Y
K
S
H
R
T
S
S
R
S
R
S
R
S
S
Site 323
S1386
S
H
R
T
S
S
R
S
R
S
R
S
S
S
Y
Site 324
S1388
R
T
S
S
R
S
R
S
R
S
S
S
Y
D
P
Site 325
S1390
S
S
R
S
R
S
R
S
S
S
Y
D
P
H
S
Site 326
S1391
S
R
S
R
S
R
S
S
S
Y
D
P
H
S
R
Site 327
S1392
R
S
R
S
R
S
S
S
Y
D
P
H
S
R
S
Site 328
Y1393
S
R
S
R
S
S
S
Y
D
P
H
S
R
S
R
Site 329
S1397
S
S
S
Y
D
P
H
S
R
S
R
S
Y
T
Y
Site 330
S1399
S
Y
D
P
H
S
R
S
R
S
Y
T
Y
D
S
Site 331
S1401
D
P
H
S
R
S
R
S
Y
T
Y
D
S
Y
Y
Site 332
Y1402
P
H
S
R
S
R
S
Y
T
Y
D
S
Y
Y
S
Site 333
T1403
H
S
R
S
R
S
Y
T
Y
D
S
Y
Y
S
R
Site 334
Y1404
S
R
S
R
S
Y
T
Y
D
S
Y
Y
S
R
S
Site 335
S1406
S
R
S
Y
T
Y
D
S
Y
Y
S
R
S
R
S
Site 336
Y1407
R
S
Y
T
Y
D
S
Y
Y
S
R
S
R
S
R
Site 337
Y1408
S
Y
T
Y
D
S
Y
Y
S
R
S
R
S
R
S
Site 338
S1409
Y
T
Y
D
S
Y
Y
S
R
S
R
S
R
S
R
Site 339
S1411
Y
D
S
Y
Y
S
R
S
R
S
R
S
R
S
Q
Site 340
S1413
S
Y
Y
S
R
S
R
S
R
S
R
S
Q
R
S
Site 341
S1415
Y
S
R
S
R
S
R
S
R
S
Q
R
S
D
S
Site 342
S1417
R
S
R
S
R
S
R
S
Q
R
S
D
S
Y
H
Site 343
S1420
S
R
S
R
S
Q
R
S
D
S
Y
H
R
G
R
Site 344
S1422
S
R
S
Q
R
S
D
S
Y
H
R
G
R
S
Y
Site 345
Y1423
R
S
Q
R
S
D
S
Y
H
R
G
R
S
Y
N
Site 346
S1428
D
S
Y
H
R
G
R
S
Y
N
R
R
S
R
S
Site 347
Y1429
S
Y
H
R
G
R
S
Y
N
R
R
S
R
S
C
Site 348
S1433
G
R
S
Y
N
R
R
S
R
S
C
R
S
Y
G
Site 349
S1435
S
Y
N
R
R
S
R
S
C
R
S
Y
G
S
D
Site 350
S1438
R
R
S
R
S
C
R
S
Y
G
S
D
S
E
S
Site 351
Y1439
R
S
R
S
C
R
S
Y
G
S
D
S
E
S
D
Site 352
S1441
R
S
C
R
S
Y
G
S
D
S
E
S
D
R
S
Site 353
S1443
C
R
S
Y
G
S
D
S
E
S
D
R
S
Y
S
Site 354
S1445
S
Y
G
S
D
S
E
S
D
R
S
Y
S
H
H
Site 355
S1448
S
D
S
E
S
D
R
S
Y
S
H
H
R
S
P
Site 356
Y1449
D
S
E
S
D
R
S
Y
S
H
H
R
S
P
S
Site 357
S1450
S
E
S
D
R
S
Y
S
H
H
R
S
P
S
E
Site 358
S1454
R
S
Y
S
H
H
R
S
P
S
E
S
S
R
Y
Site 359
S1456
Y
S
H
H
R
S
P
S
E
S
S
R
Y
S
_
Site 360
S1458
H
H
R
S
P
S
E
S
S
R
Y
S
_
_
_
Site 361
S1459
H
R
S
P
S
E
S
S
R
Y
S
_
_
_
_
Site 362
S1462
P
S
E
S
S
R
Y
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation