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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADSS
Full Name:
Adenylosuccinate synthetase isozyme 2
Alias:
ADEH; Adenylosuccinate synthase; EC 6.3.4.4; MGC20404; PURA2
Type:
Ligase; Nucleotide Metabolism - purine; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 6.3.4.4
Mass (Da):
50097
Number AA:
456
UniProt ID:
P30520
International Prot ID:
IPI00026833
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0004019
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006167
GO:0002376
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
E
T
Y
P
A
A
S
S
L
P
N
G
D
C
G
Site 2
T31
R
P
G
G
N
R
V
T
V
V
L
G
A
Q
W
Site 3
T69
G
G
N
N
A
G
H
T
V
V
V
D
S
V
E
Site 4
Y170
K
K
G
I
G
P
V
Y
S
S
K
A
A
R
S
Site 5
S171
K
G
I
G
P
V
Y
S
S
K
A
A
R
S
G
Site 6
S172
G
I
G
P
V
Y
S
S
K
A
A
R
S
G
L
Site 7
S186
L
R
M
C
D
L
V
S
D
F
D
G
F
S
E
Site 8
S192
V
S
D
F
D
G
F
S
E
R
F
K
V
L
A
Site 9
Y206
A
N
Q
Y
K
S
I
Y
P
T
L
E
I
D
I
Site 10
T208
Q
Y
K
S
I
Y
P
T
L
E
I
D
I
E
G
Site 11
Y223
E
L
Q
K
L
K
G
Y
M
E
K
I
K
P
M
Site 12
Y236
P
M
V
R
D
G
V
Y
F
L
Y
E
A
L
H
Site 13
Y239
R
D
G
V
Y
F
L
Y
E
A
L
H
G
P
P
Site 14
Y266
L
D
I
D
F
G
T
Y
P
F
V
T
S
S
N
Site 15
Y294
P
Q
N
V
G
E
V
Y
G
V
V
K
A
Y
T
Site 16
T323
E
I
G
E
L
L
Q
T
R
G
R
E
F
G
V
Site 17
T331
R
G
R
E
F
G
V
T
T
G
R
K
R
R
C
Site 18
T332
G
R
E
F
G
V
T
T
G
R
K
R
R
C
G
Site 19
Y402
L
N
K
V
E
V
Q
Y
K
T
L
P
G
W
N
Site 20
T404
K
V
E
V
Q
Y
K
T
L
P
G
W
N
T
D
Site 21
S413
P
G
W
N
T
D
I
S
N
A
R
A
F
K
E
Site 22
Y428
L
P
V
N
A
Q
N
Y
V
R
F
I
E
D
E
Site 23
S448
K
W
I
G
V
G
K
S
R
E
S
M
I
Q
L
Site 24
S451
G
V
G
K
S
R
E
S
M
I
Q
L
F
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation