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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADSL
Full Name:
Adenylosuccinate lyase
Alias:
Adenylosuccinase; AMPS; ASASE; ASL; PUR8
Type:
Lyase, Nucleotide Metabolism group, Purine metabolism family, Amino Acid Metabolism group, Alanine and aspartate metabolism family
Mass (Da):
54889
Number AA:
484
UniProt ID:
P30566
International Prot ID:
IPI00026904
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0070626
GO:0004018
PhosphoSite+
KinaseNET
Biological Process:
GO:0006189
GO:0006167
GO:0051262
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
A
G
G
D
H
G
S
P
D
S
Y
R
S
P
Site 2
S12
G
D
H
G
S
P
D
S
Y
R
S
P
L
A
S
Site 3
Y13
D
H
G
S
P
D
S
Y
R
S
P
L
A
S
R
Site 4
S15
G
S
P
D
S
Y
R
S
P
L
A
S
R
Y
A
Site 5
S19
S
Y
R
S
P
L
A
S
R
Y
A
S
P
E
M
Site 6
Y21
R
S
P
L
A
S
R
Y
A
S
P
E
M
C
F
Site 7
T58
Q
T
L
G
L
P
I
T
D
E
Q
I
Q
E
M
Site 8
S67
E
Q
I
Q
E
M
K
S
N
L
E
N
I
D
F
Site 9
Y114
H
L
G
A
T
S
C
Y
V
G
D
N
T
D
L
Site 10
S151
D
F
A
K
E
R
A
S
L
P
T
L
G
F
T
Site 11
T154
K
E
R
A
S
L
P
T
L
G
F
T
H
F
Q
Site 12
T166
H
F
Q
P
A
Q
L
T
T
V
G
K
R
C
C
Site 13
T201
R
F
R
G
V
K
G
T
T
G
T
Q
A
S
F
Site 14
S207
G
T
T
G
T
Q
A
S
F
L
Q
L
F
E
G
Site 15
T239
F
K
R
A
F
I
I
T
G
Q
T
Y
T
R
K
Site 16
Y243
F
I
I
T
G
Q
T
Y
T
R
K
V
D
I
E
Site 17
S290
E
K
Q
Q
I
G
S
S
A
M
P
Y
K
R
N
Site 18
Y294
I
G
S
S
A
M
P
Y
K
R
N
P
M
R
S
Site 19
S301
Y
K
R
N
P
M
R
S
E
R
C
C
S
L
A
Site 20
S306
M
R
S
E
R
C
C
S
L
A
R
H
L
M
T
Site 21
T330
S
V
Q
W
F
E
R
T
L
D
D
S
A
N
R
Site 22
S334
F
E
R
T
L
D
D
S
A
N
R
R
I
C
L
Site 23
T354
T
A
D
T
I
L
N
T
L
Q
N
I
S
E
G
Site 24
S407
H
E
K
I
R
V
L
S
Q
Q
A
A
S
V
V
Site 25
S412
V
L
S
Q
Q
A
A
S
V
V
K
Q
E
G
G
Site 26
Y432
E
R
I
Q
V
D
A
Y
F
S
P
I
H
S
Q
Site 27
S434
I
Q
V
D
A
Y
F
S
P
I
H
S
Q
L
D
Site 28
S438
A
Y
F
S
P
I
H
S
Q
L
D
H
L
L
D
Site 29
S448
D
H
L
L
D
P
S
S
F
T
G
R
A
S
Q
Site 30
T450
L
L
D
P
S
S
F
T
G
R
A
S
Q
Q
V
Site 31
S454
S
S
F
T
G
R
A
S
Q
Q
V
Q
R
F
L
Site 32
Y466
R
F
L
E
E
E
V
Y
P
L
L
K
P
Y
E
Site 33
Y472
V
Y
P
L
L
K
P
Y
E
S
V
M
K
V
K
Site 34
S474
P
L
L
K
P
Y
E
S
V
M
K
V
K
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation