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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GCH1
Full Name:
GTP cyclohydrolase 1
Alias:
Dopa-responsive dystonia; DYT5; DYT5a; GCH; GTP cyclohydrolase I; GTPCH1; GTPCH-1; GTP-CH-I
Type:
EC 3.5.4.16; Cofactor and Vitamin Metabolism - folate biosynthesis; Hydrolase
Mass (Da):
27903
Number AA:
250
UniProt ID:
P30793
International Prot ID:
IPI00027492
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031410
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003934
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0006184
GO:0042416
GO:0050884
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
K
P
R
G
A
R
C
S
N
G
F
P
E
R
D
Site 2
S33
D
P
P
R
P
G
P
S
R
P
A
E
K
P
P
Site 3
S46
P
P
R
P
E
A
K
S
A
Q
P
A
D
G
W
Site 4
S60
W
K
G
E
R
P
R
S
E
E
D
N
E
L
N
Site 5
S80
A
A
Y
S
S
I
L
S
S
L
G
E
N
P
Q
Site 6
S81
A
Y
S
S
I
L
S
S
L
G
E
N
P
Q
R
Site 7
T94
Q
R
Q
G
L
L
K
T
P
W
R
A
A
S
A
Site 8
S100
K
T
P
W
R
A
A
S
A
M
Q
F
F
T
K
Site 9
T112
F
T
K
G
Y
Q
E
T
I
S
D
V
L
N
D
Site 10
S114
K
G
Y
Q
E
T
I
S
D
V
L
N
D
A
I
Site 11
S139
V
K
D
I
D
M
F
S
M
C
E
H
H
L
V
Site 12
Y175
L
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
Site 13
S176
A
R
I
V
E
I
Y
S
R
R
L
Q
V
Q
E
Site 14
S223
R
G
V
Q
K
M
N
S
K
T
V
T
S
T
M
Site 15
T225
V
Q
K
M
N
S
K
T
V
T
S
T
M
L
G
Site 16
T240
V
F
R
E
D
P
K
T
R
E
E
F
L
T
L
Site 17
T246
K
T
R
E
E
F
L
T
L
I
R
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation