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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHRNB4
Full Name:
Neuronal acetylcholine receptor subunit beta-4
Alias:
Type:
Mass (Da):
56380
Number AA:
498
UniProt ID:
P30926
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T38
M
D
D
L
L
N
K
T
R
Y
N
N
L
I
R
Site 2
Y40
D
L
L
N
K
T
R
Y
N
N
L
I
R
P
A
Site 3
T48
N
N
L
I
R
P
A
T
S
S
S
Q
L
I
S
Site 4
T76
N
E
R
E
Q
I
M
T
T
N
V
W
L
K
Q
Site 5
Y88
L
K
Q
E
W
T
D
Y
R
L
T
W
N
S
S
Site 6
S94
D
Y
R
L
T
W
N
S
S
R
Y
E
G
V
N
Site 7
Y118
W
L
P
D
I
V
L
Y
N
N
A
D
G
T
Y
Site 8
T124
L
Y
N
N
A
D
G
T
Y
E
V
S
V
Y
T
Site 9
Y125
Y
N
N
A
D
G
T
Y
E
V
S
V
Y
T
N
Site 10
Y159
A
C
K
I
E
V
K
Y
F
P
F
D
Q
Q
N
Site 11
T175
T
L
K
F
R
S
W
T
Y
D
H
T
E
I
D
Site 12
T196
T
A
S
M
D
D
F
T
P
S
G
E
W
D
I
Site 13
S198
S
M
D
D
F
T
P
S
G
E
W
D
I
V
A
Site 14
T211
V
A
L
P
G
R
R
T
V
N
P
Q
D
P
S
Site 15
S218
T
V
N
P
Q
D
P
S
Y
V
D
V
T
Y
D
Site 16
Y219
V
N
P
Q
D
P
S
Y
V
D
V
T
Y
D
F
Site 17
T223
D
P
S
Y
V
D
V
T
Y
D
F
I
I
K
R
Site 18
Y224
P
S
Y
V
D
V
T
Y
D
F
I
I
K
R
K
Site 19
S323
V
L
N
V
H
H
R
S
P
S
T
H
T
M
A
Site 20
T326
V
H
H
R
S
P
S
T
H
T
M
A
P
W
V
Site 21
S354
M
K
R
P
G
P
D
S
S
P
A
R
A
F
P
Site 22
S355
K
R
P
G
P
D
S
S
P
A
R
A
F
P
P
Site 23
S363
P
A
R
A
F
P
P
S
K
S
C
V
T
K
P
Site 24
S365
R
A
F
P
P
S
K
S
C
V
T
K
P
E
A
Site 25
T375
T
K
P
E
A
T
A
T
S
T
S
P
S
N
F
Site 26
S376
K
P
E
A
T
A
T
S
T
S
P
S
N
F
Y
Site 27
S378
E
A
T
A
T
S
T
S
P
S
N
F
Y
G
N
Site 28
S380
T
A
T
S
T
S
P
S
N
F
Y
G
N
S
M
Site 29
Y388
N
F
Y
G
N
S
M
Y
F
V
N
P
A
S
A
Site 30
S394
M
Y
F
V
N
P
A
S
A
A
S
K
S
P
A
Site 31
S397
V
N
P
A
S
A
A
S
K
S
P
A
G
S
T
Site 32
S399
P
A
S
A
A
S
K
S
P
A
G
S
T
P
V
Site 33
S403
A
S
K
S
P
A
G
S
T
P
V
A
I
P
R
Site 34
T404
S
K
S
P
A
G
S
T
P
V
A
I
P
R
D
Site 35
S416
P
R
D
F
W
L
R
S
S
G
R
F
R
Q
D
Site 36
S417
R
D
F
W
L
R
S
S
G
R
F
R
Q
D
V
Site 37
S432
Q
E
A
L
E
G
V
S
F
I
A
Q
H
M
K
Site 38
S446
K
N
D
D
E
D
Q
S
V
V
E
D
W
K
Y
Site 39
T485
F
L
P
P
L
F
Q
T
H
A
A
S
E
G
P
Site 40
Y493
H
A
A
S
E
G
P
Y
A
A
Q
R
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation