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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAT2A
Full Name:
S-adenosylmethionine synthase isoform type-2
Alias:
Adomet synthetase 2; AMS2; EC 2.5.1.6; MATA2; MATII; MAT-II; Methionine adenosyltransferase 2; Methionine adenosyltransferase II, alpha; METK2; SAMS2
Type:
Uncharacterized protein
Mass (Da):
43661
Number AA:
395
UniProt ID:
P31153
International Prot ID:
IPI00010157
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0050897
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006730
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
E
A
F
I
E
E
G
T
F
L
F
T
S
E
S
Site 2
S22
E
G
T
F
L
F
T
S
E
S
V
G
E
G
H
Site 3
S24
T
F
L
F
T
S
E
S
V
G
E
G
H
P
D
Site 4
S38
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
Site 5
Y79
T
S
R
A
A
V
D
Y
Q
K
V
V
R
E
A
Site 6
Y92
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
Site 7
S95
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
Site 8
S96
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
Site 9
Y101
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
Site 10
S114
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
Site 11
T146
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
Site 12
T172
A
E
L
R
R
N
G
T
L
P
W
L
R
P
D
Site 13
S180
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Site 14
T182
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Site 15
T185
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
R
Site 16
Y188
K
T
Q
V
T
V
Q
Y
M
Q
D
R
G
A
V
Site 17
S206
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
Site 18
Y235
K
A
V
V
P
A
K
Y
L
D
E
D
T
I
Y
Site 19
T240
A
K
Y
L
D
E
D
T
I
Y
H
L
Q
P
S
Site 20
Y242
Y
L
D
E
D
T
I
Y
H
L
Q
P
S
G
R
Site 21
T262
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
Site 22
T270
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
Site 23
Y271
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
Site 24
S283
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
Site 25
Y287
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
Site 26
T288
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Site 27
S293
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
Site 28
Y335
L
S
I
S
I
F
H
Y
G
T
S
Q
K
S
E
Site 29
S338
S
I
F
H
Y
G
T
S
Q
K
S
E
R
E
L
Site 30
S341
H
Y
G
T
S
Q
K
S
E
R
E
L
L
E
I
Site 31
Y371
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
Site 32
Y377
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
S
Site 33
S384
Y
G
H
F
G
R
D
S
F
P
W
E
V
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation