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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HOXD3
Full Name:
Homeobox protein Hox-D3
Alias:
Homeobox protein Hox-4A
Type:
Mass (Da):
45730
Number AA:
432
UniProt ID:
P31249
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
C
T
M
Q
K
A
A
Y
Y
E
N
P
G
L
F
Site 2
Y23
T
M
Q
K
A
A
Y
Y
E
N
P
G
L
F
G
Site 3
S35
L
F
G
G
Y
G
Y
S
K
T
T
D
T
Y
G
Site 4
T37
G
G
Y
G
Y
S
K
T
T
D
T
Y
G
Y
S
Site 5
T38
G
Y
G
Y
S
K
T
T
D
T
Y
G
Y
S
T
Site 6
T40
G
Y
S
K
T
T
D
T
Y
G
Y
S
T
P
H
Site 7
Y41
Y
S
K
T
T
D
T
Y
G
Y
S
T
P
H
Q
Site 8
Y43
K
T
T
D
T
Y
G
Y
S
T
P
H
Q
P
Y
Site 9
S44
T
T
D
T
Y
G
Y
S
T
P
H
Q
P
Y
P
Site 10
T45
T
D
T
Y
G
Y
S
T
P
H
Q
P
Y
P
P
Site 11
Y50
Y
S
T
P
H
Q
P
Y
P
P
P
A
A
A
S
Site 12
T61
A
A
A
S
S
L
D
T
D
Y
P
G
S
A
C
Site 13
Y63
A
S
S
L
D
T
D
Y
P
G
S
A
C
S
I
Site 14
S66
L
D
T
D
Y
P
G
S
A
C
S
I
Q
S
S
Site 15
S69
D
Y
P
G
S
A
C
S
I
Q
S
S
A
P
L
Site 16
S72
G
S
A
C
S
I
Q
S
S
A
P
L
R
A
P
Site 17
S73
S
A
C
S
I
Q
S
S
A
P
L
R
A
P
A
Site 18
S89
K
G
A
E
L
N
G
S
C
M
R
P
G
T
G
Site 19
T95
G
S
C
M
R
P
G
T
G
N
S
Q
G
G
G
Site 20
S98
M
R
P
G
T
G
N
S
Q
G
G
G
G
G
S
Site 21
S105
S
Q
G
G
G
G
G
S
Q
P
P
G
L
N
S
Site 22
S112
S
Q
P
P
G
L
N
S
E
Q
Q
P
P
Q
P
Site 23
T125
Q
P
P
P
P
P
P
T
L
P
P
S
S
P
T
Site 24
S129
P
P
P
T
L
P
P
S
S
P
T
N
P
G
G
Site 25
S130
P
P
T
L
P
P
S
S
P
T
N
P
G
G
G
Site 26
S150
P
K
G
G
P
N
A
S
S
S
S
A
T
I
S
Site 27
S151
K
G
G
P
N
A
S
S
S
S
A
T
I
S
K
Site 28
S152
G
G
P
N
A
S
S
S
S
A
T
I
S
K
Q
Site 29
S153
G
P
N
A
S
S
S
S
A
T
I
S
K
Q
I
Site 30
T155
N
A
S
S
S
S
A
T
I
S
K
Q
I
F
P
Site 31
S157
S
S
S
S
A
T
I
S
K
Q
I
F
P
W
M
Site 32
S171
M
K
E
S
R
Q
N
S
K
Q
K
N
S
C
A
Site 33
S188
G
E
S
C
E
D
K
S
P
P
G
P
A
S
K
Site 34
S194
K
S
P
P
G
P
A
S
K
R
V
R
T
A
Y
Site 35
T199
P
A
S
K
R
V
R
T
A
Y
T
S
A
Q
L
Site 36
Y201
S
K
R
V
R
T
A
Y
T
S
A
Q
L
V
E
Site 37
S203
R
V
R
T
A
Y
T
S
A
Q
L
V
E
L
E
Site 38
Y218
K
E
F
H
F
N
R
Y
L
C
R
P
R
R
V
Site 39
T234
M
A
N
L
L
N
L
T
E
R
Q
I
K
I
W
Site 40
Y249
F
Q
N
R
R
M
K
Y
K
K
D
Q
K
A
K
Site 41
S261
K
A
K
G
I
L
H
S
P
A
S
Q
S
P
E
Site 42
S264
G
I
L
H
S
P
A
S
Q
S
P
E
R
S
P
Site 43
S266
L
H
S
P
A
S
Q
S
P
E
R
S
P
P
L
Site 44
S270
A
S
Q
S
P
E
R
S
P
P
L
G
G
A
A
Site 45
Y294
P
P
V
P
G
L
A
Y
D
A
P
S
P
P
A
Site 46
S298
G
L
A
Y
D
A
P
S
P
P
A
F
A
K
S
Site 47
S305
S
P
P
A
F
A
K
S
Q
P
N
M
Y
G
L
Site 48
S320
A
A
Y
T
A
P
L
S
S
C
L
P
Q
Q
K
Site 49
Y329
C
L
P
Q
Q
K
R
Y
A
A
P
E
F
E
P
Site 50
S341
F
E
P
H
P
M
A
S
N
G
G
G
F
A
S
Site 51
S348
S
N
G
G
G
F
A
S
A
N
L
Q
G
S
P
Site 52
S354
A
S
A
N
L
Q
G
S
P
V
Y
V
G
G
N
Site 53
Y357
N
L
Q
G
S
P
V
Y
V
G
G
N
F
V
E
Site 54
S383
L
G
H
L
S
H
P
S
S
A
S
V
D
Y
S
Site 55
S384
G
H
L
S
H
P
S
S
A
S
V
D
Y
S
C
Site 56
S386
L
S
H
P
S
S
A
S
V
D
Y
S
C
A
A
Site 57
Y389
P
S
S
A
S
V
D
Y
S
C
A
A
Q
I
P
Site 58
S390
S
S
A
S
V
D
Y
S
C
A
A
Q
I
P
G
Site 59
T409
G
P
C
D
P
H
P
T
Y
T
D
L
S
A
H
Site 60
Y410
P
C
D
P
H
P
T
Y
T
D
L
S
A
H
H
Site 61
S414
H
P
T
Y
T
D
L
S
A
H
H
S
S
Q
G
Site 62
S418
T
D
L
S
A
H
H
S
S
Q
G
R
L
P
E
Site 63
S419
D
L
S
A
H
H
S
S
Q
G
R
L
P
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation