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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKAR1B
Full Name:
cAMP-dependent protein kinase type I-beta regulatory subunit
Alias:
KAP1; PRKAR1B; Protein kinase, cAMP-dependent, regulatory, type I, beta
Type:
Protein-serine kinase regulatory subunit
Mass (Da):
43073
Number AA:
381
UniProt ID:
P31321
International Prot ID:
IPI00554488
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005952
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0030552
GO:0008603
PhosphoSite+
KinaseNET
Biological Process:
GO:0034199
GO:0009755
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
P
P
A
C
P
S
E
Site 2
S9
A
S
P
P
A
C
P
S
E
E
D
E
S
L
K
Site 3
S14
C
P
S
E
E
D
E
S
L
K
G
C
E
L
Y
Site 4
S71
Q
I
L
A
R
Q
K
S
N
S
Q
S
D
S
H
Site 5
S73
L
A
R
Q
K
S
N
S
Q
S
D
S
H
D
E
Site 6
S75
R
Q
K
S
N
S
Q
S
D
S
H
D
E
E
V
Site 7
S77
K
S
N
S
Q
S
D
S
H
D
E
E
V
S
P
Site 8
S83
D
S
H
D
E
E
V
S
P
T
P
P
N
P
V
Site 9
T85
H
D
E
E
V
S
P
T
P
P
N
P
V
V
K
Site 10
S101
R
R
R
R
G
G
V
S
A
E
V
Y
T
E
E
Site 11
Y105
G
G
V
S
A
E
V
Y
T
E
E
D
A
V
S
Site 12
S112
Y
T
E
E
D
A
V
S
Y
V
R
K
V
I
P
Site 13
Y113
T
E
E
D
A
V
S
Y
V
R
K
V
I
P
K
Site 14
Y122
R
K
V
I
P
K
D
Y
K
T
M
T
A
L
A
Site 15
T124
V
I
P
K
D
Y
K
T
M
T
A
L
A
K
A
Site 16
Y175
G
N
E
G
D
N
F
Y
V
V
D
Q
G
E
V
Site 17
Y185
D
Q
G
E
V
D
V
Y
V
N
G
E
W
V
T
Site 18
S195
G
E
W
V
T
N
I
S
E
G
G
S
F
G
E
Site 19
Y207
F
G
E
L
A
L
I
Y
G
T
P
R
A
A
T
Site 20
T214
Y
G
T
P
R
A
A
T
V
K
A
K
T
D
L
Site 21
Y231
W
G
I
D
R
D
S
Y
R
R
I
L
M
G
S
Site 22
S238
Y
R
R
I
L
M
G
S
T
L
R
K
R
K
M
Site 23
T239
R
R
I
L
M
G
S
T
L
R
K
R
K
M
Y
Site 24
Y246
T
L
R
K
R
K
M
Y
E
E
F
L
S
K
V
Site 25
S251
K
M
Y
E
E
F
L
S
K
V
S
I
L
E
S
Site 26
S254
E
E
F
L
S
K
V
S
I
L
E
S
L
E
K
Site 27
S258
S
K
V
S
I
L
E
S
L
E
K
W
E
R
L
Site 28
T266
L
E
K
W
E
R
L
T
V
A
D
A
L
E
P
Site 29
Y293
G
E
P
G
D
D
F
Y
I
I
T
E
G
T
A
Site 30
S301
I
I
T
E
G
T
A
S
V
L
Q
R
R
S
P
Site 31
S307
A
S
V
L
Q
R
R
S
P
N
E
E
Y
V
E
Site 32
Y312
R
R
S
P
N
E
E
Y
V
E
V
G
R
L
G
Site 33
S321
E
V
G
R
L
G
P
S
D
Y
F
G
E
I
A
Site 34
T338
L
N
R
P
R
A
A
T
V
V
A
R
G
P
L
Site 35
S363
E
R
V
L
G
P
C
S
E
I
L
K
R
N
I
Site 36
Y373
L
K
R
N
I
Q
R
Y
N
S
F
I
S
L
T
Site 37
S375
R
N
I
Q
R
Y
N
S
F
I
S
L
T
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation