KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TIA1
Full Name:
Nucleolysin TIA-1 isoform p40
Alias:
P40-TIA-1; RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA1 cytotoxic granule-associated RNA binding protein
Type:
RNA binding protein
Mass (Da):
42961
Number AA:
386
UniProt ID:
P31483
International Prot ID:
IPI00291398
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0008143
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0006917
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
E
D
E
M
P
K
T
L
Y
V
G
N
L
S
Site 2
Y10
D
E
M
P
K
T
L
Y
V
G
N
L
S
R
D
Site 3
Y48
D
T
A
G
N
D
P
Y
C
F
V
E
F
H
E
Site 4
T82
E
V
K
V
N
W
A
T
T
P
S
S
Q
K
K
Site 5
T83
V
K
V
N
W
A
T
T
P
S
S
Q
K
K
D
Site 6
S86
N
W
A
T
T
P
S
S
Q
K
K
D
T
S
S
Site 7
T91
P
S
S
Q
K
K
D
T
S
S
S
T
V
V
S
Site 8
S92
S
S
Q
K
K
D
T
S
S
S
T
V
V
S
T
Site 9
S93
S
Q
K
K
D
T
S
S
S
T
V
V
S
T
Q
Site 10
S94
Q
K
K
D
T
S
S
S
T
V
V
S
T
Q
R
Site 11
T95
K
K
D
T
S
S
S
T
V
V
S
T
Q
R
S
Site 12
S98
T
S
S
S
T
V
V
S
T
Q
R
S
Q
D
H
Site 13
T99
S
S
S
T
V
V
S
T
Q
R
S
Q
D
H
F
Site 14
S102
T
V
V
S
T
Q
R
S
Q
D
H
F
H
V
F
Site 15
S114
H
V
F
V
G
D
L
S
P
E
I
T
T
E
D
Site 16
T118
G
D
L
S
P
E
I
T
T
E
D
I
K
A
A
Site 17
S133
F
A
P
F
G
R
I
S
D
A
R
V
V
K
D
Site 18
T143
R
V
V
K
D
M
A
T
G
K
S
K
G
Y
G
Site 19
S146
K
D
M
A
T
G
K
S
K
G
Y
G
F
V
S
Site 20
Y149
A
T
G
K
S
K
G
Y
G
F
V
S
F
F
N
Site 21
T183
Q
I
R
T
N
W
A
T
R
K
P
P
A
P
K
Site 22
S191
R
K
P
P
A
P
K
S
T
Y
E
S
N
T
K
Site 23
Y193
P
P
A
P
K
S
T
Y
E
S
N
T
K
Q
L
Site 24
S195
A
P
K
S
T
Y
E
S
N
T
K
Q
L
S
Y
Site 25
S201
E
S
N
T
K
Q
L
S
Y
D
E
V
V
N
Q
Site 26
Y202
S
N
T
K
Q
L
S
Y
D
E
V
V
N
Q
S
Site 27
S209
Y
D
E
V
V
N
Q
S
S
P
S
N
C
T
V
Site 28
S210
D
E
V
V
N
Q
S
S
P
S
N
C
T
V
Y
Site 29
T215
Q
S
S
P
S
N
C
T
V
Y
C
G
G
V
T
Site 30
Y217
S
P
S
N
C
T
V
Y
C
G
G
V
T
S
G
Site 31
T233
T
E
Q
L
M
R
Q
T
F
S
P
F
G
Q
I
Site 32
S235
Q
L
M
R
Q
T
F
S
P
F
G
Q
I
M
E
Site 33
Y251
R
V
F
P
D
K
G
Y
S
F
V
R
F
N
S
Site 34
S252
V
F
P
D
K
G
Y
S
F
V
R
F
N
S
H
Site 35
S258
Y
S
F
V
R
F
N
S
H
E
S
A
A
H
A
Site 36
Y282
E
G
H
V
V
K
C
Y
W
G
K
E
T
L
D
Site 37
Y302
Q
Q
Q
N
Q
I
G
Y
P
Q
P
Y
G
Q
W
Site 38
Y358
A
P
W
M
G
P
N
Y
G
V
Q
P
P
Q
G
Site 39
S369
P
P
Q
G
Q
N
G
S
M
L
P
N
Q
P
S
Site 40
S376
S
M
L
P
N
Q
P
S
G
Y
R
V
A
G
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation