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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FMO4
Full Name:
Dimethylaniline monooxygenase [N-oxide-forming] 4
Alias:
Dimethylaniline oxidase 4; Flavin containing monooxygenase 4; FMO 4; FMO2; Hepatic flavin-containing monooxygenase 4
Type:
Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.13.8; Oxidoreductase
Mass (Da):
63210
Number AA:
UniProt ID:
P31512
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0031227
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0050661
GO:0004499
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0006805
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
E
P
T
C
F
E
R
S
D
D
I
G
G
L
W
Site 2
T44
I
G
G
L
W
K
F
T
E
S
S
K
D
G
M
Site 3
S47
L
W
K
F
T
E
S
S
K
D
G
M
T
R
V
Site 4
T52
E
S
S
K
D
G
M
T
R
V
Y
K
S
L
V
Site 5
Y55
K
D
G
M
T
R
V
Y
K
S
L
V
T
N
V
Site 6
Y69
V
C
K
E
M
S
C
Y
S
D
F
P
F
H
E
Site 7
Y103
E
H
F
D
L
L
K
Y
I
Q
F
K
T
T
V
Site 8
T109
K
Y
I
Q
F
K
T
T
V
C
S
I
T
K
R
Site 9
S112
Q
F
K
T
T
V
C
S
I
T
K
R
P
D
F
Site 10
T114
K
T
T
V
C
S
I
T
K
R
P
D
F
S
E
Site 11
T129
T
G
Q
W
D
V
V
T
E
T
E
G
K
Q
N
Site 12
S173
F
K
G
Q
I
L
H
S
Q
E
Y
K
I
P
E
Site 13
Y176
Q
I
L
H
S
Q
E
Y
K
I
P
E
G
F
Q
Site 14
T218
L
L
S
T
R
T
G
T
W
V
L
G
R
S
S
Site 15
Y231
S
S
D
W
G
Y
P
Y
N
M
M
V
T
R
R
Site 16
S241
M
V
T
R
R
C
C
S
F
I
A
Q
V
L
P
Site 17
S249
F
I
A
Q
V
L
P
S
R
F
L
N
W
I
Q
Site 18
Y269
K
R
F
N
H
E
D
Y
G
L
S
I
T
K
G
Site 19
T316
S
A
V
F
E
D
G
T
V
E
E
N
I
D
V
Site 20
S333
F
T
T
G
Y
T
F
S
F
P
F
F
E
E
P
Site 21
S343
F
F
E
E
P
L
K
S
L
C
T
K
K
I
F
Site 22
T346
E
P
L
K
S
L
C
T
K
K
I
F
L
Y
K
Site 23
S379
G
L
K
G
S
I
L
S
G
T
E
L
Q
A
R
Site 24
S401
G
L
C
K
I
P
P
S
Q
K
L
M
M
E
A
Site 25
T423
K
R
G
V
F
K
D
T
S
K
D
K
F
D
Y
Site 26
S424
R
G
V
F
K
D
T
S
K
D
K
F
D
Y
I
Site 27
Y430
T
S
K
D
K
F
D
Y
I
A
Y
M
D
D
I
Site 28
Y433
D
K
F
D
Y
I
A
Y
M
D
D
I
A
A
C
Site 29
Y469
F
F
G
P
C
T
P
Y
Q
Y
R
L
M
G
P
Site 30
Y471
G
P
C
T
P
Y
Q
Y
R
L
M
G
P
G
K
Site 31
T488
G
A
R
N
A
I
L
T
Q
W
D
R
T
L
K
Site 32
T493
I
L
T
Q
W
D
R
T
L
K
P
L
K
T
R
Site 33
T499
R
T
L
K
P
L
K
T
R
I
V
P
D
S
S
Site 34
S505
K
T
R
I
V
P
D
S
S
K
P
A
S
M
S
Site 35
S506
T
R
I
V
P
D
S
S
K
P
A
S
M
S
H
Site 36
S510
P
D
S
S
K
P
A
S
M
S
H
Y
L
K
A
Site 37
S512
S
S
K
P
A
S
M
S
H
Y
L
K
A
W
G
Site 38
Y514
K
P
A
S
M
S
H
Y
L
K
A
W
G
A
P
Site 39
S549
D
K
L
Q
D
R
M
S
P
Y
L
V
S
L
W
Site 40
Y551
L
Q
D
R
M
S
P
Y
L
V
S
L
W
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation