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Updated November 2019
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Protein Info
Short Name:
HIVEP2
Full Name:
Transcription factor HIVEP2
Alias:
C-myc intron binding protein 1; HIV- EP2; HIV-EP2; HIV-EP2/Schnurri-2; Human immunodeficiency virus type I enhancer binding protein 2; MBP-2; MHC-binding protein 2; MIBP1; Schnurri-2; ZAS2; ZEP2; ZNF40B
Type:
DNA binding protein
Mass (Da):
269053
Number AA:
2446
UniProt ID:
P31629
International Prot ID:
IPI00144243
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
S
G
E
T
D
K
A
S
G
R
W
R
Q
E
Q
Site 2
S37
Q
S
A
V
I
K
M
S
T
F
G
S
H
E
G
Site 3
T38
S
A
V
I
K
M
S
T
F
G
S
H
E
G
Q
Site 4
S41
I
K
M
S
T
F
G
S
H
E
G
Q
R
Q
P
Site 5
S60
E
Q
I
G
N
T
A
S
A
Q
L
F
G
S
G
Site 6
S66
A
S
A
Q
L
F
G
S
G
K
L
A
S
P
S
Site 7
S71
F
G
S
G
K
L
A
S
P
S
E
V
V
Q
Q
Site 8
S73
S
G
K
L
A
S
P
S
E
V
V
Q
Q
V
A
Site 9
Y84
Q
Q
V
A
E
K
Q
Y
P
P
H
R
P
S
P
Site 10
S90
Q
Y
P
P
H
R
P
S
P
Y
S
C
Q
H
S
Site 11
Y92
P
P
H
R
P
S
P
Y
S
C
Q
H
S
L
S
Site 12
S93
P
H
R
P
S
P
Y
S
C
Q
H
S
L
S
F
Site 13
S97
S
P
Y
S
C
Q
H
S
L
S
F
P
Q
H
S
Site 14
S99
Y
S
C
Q
H
S
L
S
F
P
Q
H
S
L
P
Site 15
S104
S
L
S
F
P
Q
H
S
L
P
Q
G
V
M
H
Site 16
S112
L
P
Q
G
V
M
H
S
T
K
P
H
Q
S
L
Site 17
S118
H
S
T
K
P
H
Q
S
L
E
G
P
P
W
L
Site 18
S147
P
F
P
I
H
G
H
S
G
G
Y
P
R
K
K
Site 19
Y150
I
H
G
H
S
G
G
Y
P
R
K
K
I
S
S
Site 20
S157
Y
P
R
K
K
I
S
S
L
N
P
A
Y
S
Q
Site 21
Y162
I
S
S
L
N
P
A
Y
S
Q
Y
S
Q
K
S
Site 22
S163
S
S
L
N
P
A
Y
S
Q
Y
S
Q
K
S
I
Site 23
S166
N
P
A
Y
S
Q
Y
S
Q
K
S
I
E
Q
A
Site 24
S169
Y
S
Q
Y
S
Q
K
S
I
E
Q
A
E
E
A
Site 25
Y189
K
P
K
K
P
G
K
Y
I
C
P
Y
C
S
R
Site 26
Y193
P
G
K
Y
I
C
P
Y
C
S
R
A
C
A
K
Site 27
S202
S
R
A
C
A
K
P
S
V
L
K
K
H
I
R
Site 28
T212
K
K
H
I
R
S
H
T
G
E
R
P
Y
P
C
Site 29
Y217
S
H
T
G
E
R
P
Y
P
C
I
P
C
G
F
Site 30
T228
P
C
G
F
S
F
K
T
K
S
N
L
Y
K
H
Site 31
S230
G
F
S
F
K
T
K
S
N
L
Y
K
H
R
K
Site 32
Y233
F
K
T
K
S
N
L
Y
K
H
R
K
S
H
A
Site 33
S238
N
L
Y
K
H
R
K
S
H
A
H
A
I
K
A
Site 34
S256
P
F
T
E
S
A
V
S
K
L
D
L
E
A
G
Site 35
S273
D
V
E
A
E
I
H
S
D
G
E
Q
S
T
D
Site 36
T281
D
G
E
Q
S
T
D
T
D
E
E
S
S
L
F
Site 37
S292
S
S
L
F
A
E
A
S
D
K
M
S
P
G
P
Site 38
S296
A
E
A
S
D
K
M
S
P
G
P
P
I
P
L
Site 39
S307
P
I
P
L
D
I
A
S
R
G
G
Y
H
G
S
Site 40
Y311
D
I
A
S
R
G
G
Y
H
G
S
L
E
E
S
Site 41
S314
S
R
G
G
Y
H
G
S
L
E
E
S
L
G
G
Site 42
S318
Y
H
G
S
L
E
E
S
L
G
G
P
M
K
V
Site 43
S341
G
I
P
L
P
N
E
S
S
Q
Y
I
G
P
D
Site 44
S342
I
P
L
P
N
E
S
S
Q
Y
I
G
P
D
M
Site 45
Y344
L
P
N
E
S
S
Q
Y
I
G
P
D
M
L
P
Site 46
S354
P
D
M
L
P
N
P
S
L
N
T
K
A
D
D
Site 47
S362
L
N
T
K
A
D
D
S
H
T
V
K
Q
K
L
Site 48
T364
T
K
A
D
D
S
H
T
V
K
Q
K
L
A
L
Site 49
S374
Q
K
L
A
L
R
L
S
E
K
K
G
Q
D
S
Site 50
S381
S
E
K
K
G
Q
D
S
E
P
S
L
N
L
L
Site 51
S384
K
G
Q
D
S
E
P
S
L
N
L
L
S
P
H
Site 52
S389
E
P
S
L
N
L
L
S
P
H
S
K
G
S
T
Site 53
S392
L
N
L
L
S
P
H
S
K
G
S
T
D
S
G
Site 54
S395
L
S
P
H
S
K
G
S
T
D
S
G
Y
F
S
Site 55
T396
S
P
H
S
K
G
S
T
D
S
G
Y
F
S
R
Site 56
S398
H
S
K
G
S
T
D
S
G
Y
F
S
R
S
E
Site 57
Y400
K
G
S
T
D
S
G
Y
F
S
R
S
E
S
A
Site 58
S402
S
T
D
S
G
Y
F
S
R
S
E
S
A
E
Q
Site 59
S404
D
S
G
Y
F
S
R
S
E
S
A
E
Q
Q
I
Site 60
S406
G
Y
F
S
R
S
E
S
A
E
Q
Q
I
S
P
Site 61
S412
E
S
A
E
Q
Q
I
S
P
P
N
T
N
A
K
Site 62
T416
Q
Q
I
S
P
P
N
T
N
A
K
S
Y
E
E
Site 63
S420
P
P
N
T
N
A
K
S
Y
E
E
I
I
F
G
Site 64
Y421
P
N
T
N
A
K
S
Y
E
E
I
I
F
G
K
Site 65
Y429
E
E
I
I
F
G
K
Y
C
R
L
S
P
R
N
Site 66
S433
F
G
K
Y
C
R
L
S
P
R
N
A
L
S
V
Site 67
S439
L
S
P
R
N
A
L
S
V
T
T
T
S
Q
E
Site 68
T443
N
A
L
S
V
T
T
T
S
Q
E
R
A
A
M
Site 69
S444
A
L
S
V
T
T
T
S
Q
E
R
A
A
M
G
Site 70
S476
K
M
F
E
D
P
V
S
Q
L
I
P
S
K
G
Site 71
S488
S
K
G
D
V
D
P
S
Q
T
S
M
L
K
S
Site 72
S491
D
V
D
P
S
Q
T
S
M
L
K
S
T
K
F
Site 73
S495
S
Q
T
S
M
L
K
S
T
K
F
N
S
E
S
Site 74
T496
Q
T
S
M
L
K
S
T
K
F
N
S
E
S
R
Site 75
S500
L
K
S
T
K
F
N
S
E
S
R
Q
P
Q
I
Site 76
S511
Q
P
Q
I
I
P
S
S
I
R
N
E
G
K
L
Site 77
Y519
I
R
N
E
G
K
L
Y
P
A
N
F
Q
G
S
Site 78
S537
L
L
E
A
P
V
D
S
S
P
L
I
R
S
N
Site 79
S538
L
E
A
P
V
D
S
S
P
L
I
R
S
N
S
Site 80
S543
D
S
S
P
L
I
R
S
N
S
V
P
T
S
S
Site 81
S545
S
P
L
I
R
S
N
S
V
P
T
S
S
A
T
Site 82
S549
R
S
N
S
V
P
T
S
S
A
T
N
L
T
I
Site 83
S550
S
N
S
V
P
T
S
S
A
T
N
L
T
I
P
Site 84
T555
T
S
S
A
T
N
L
T
I
P
P
S
L
R
G
Site 85
S559
T
N
L
T
I
P
P
S
L
R
G
S
H
S
F
Site 86
S563
I
P
P
S
L
R
G
S
H
S
F
D
E
R
M
Site 87
S565
P
S
L
R
G
S
H
S
F
D
E
R
M
T
G
Site 88
T571
H
S
F
D
E
R
M
T
G
S
D
D
V
F
Y
Site 89
S573
F
D
E
R
M
T
G
S
D
D
V
F
Y
P
G
Site 90
Y578
T
G
S
D
D
V
F
Y
P
G
T
V
G
I
P
Site 91
T581
D
D
V
F
Y
P
G
T
V
G
I
P
P
Q
R
Site 92
S600
Q
A
A
F
E
L
P
S
V
Q
E
G
H
V
E
Site 93
S619
G
R
M
L
K
G
I
S
S
S
S
L
K
E
K
Site 94
S620
R
M
L
K
G
I
S
S
S
S
L
K
E
K
K
Site 95
S622
L
K
G
I
S
S
S
S
L
K
E
K
K
L
S
Site 96
S629
S
L
K
E
K
K
L
S
P
G
D
R
V
G
Y
Site 97
Y636
S
P
G
D
R
V
G
Y
D
Y
D
V
C
R
K
Site 98
Y638
G
D
R
V
G
Y
D
Y
D
V
C
R
K
P
Y
Site 99
Y645
Y
D
V
C
R
K
P
Y
K
K
W
E
D
S
E
Site 100
S651
P
Y
K
K
W
E
D
S
E
T
P
K
Q
N
Y
Site 101
T653
K
K
W
E
D
S
E
T
P
K
Q
N
Y
R
D
Site 102
Y658
S
E
T
P
K
Q
N
Y
R
D
I
S
C
L
S
Site 103
S662
K
Q
N
Y
R
D
I
S
C
L
S
S
L
K
H
Site 104
S665
Y
R
D
I
S
C
L
S
S
L
K
H
G
G
E
Site 105
S666
R
D
I
S
C
L
S
S
L
K
H
G
G
E
Y
Site 106
Y673
S
L
K
H
G
G
E
Y
F
M
D
P
V
V
P
Site 107
T690
G
V
P
S
M
F
G
T
T
C
E
N
R
K
R
Site 108
S702
R
K
R
R
K
E
K
S
V
G
D
E
E
D
T
Site 109
T709
S
V
G
D
E
E
D
T
P
M
I
C
S
S
I
Site 110
S726
T
P
V
G
I
M
A
S
D
Y
D
P
K
L
Q
Site 111
Y728
V
G
I
M
A
S
D
Y
D
P
K
L
Q
M
Q
Site 112
S740
Q
M
Q
E
G
V
R
S
G
F
A
M
A
G
H
Site 113
T755
E
N
L
S
H
G
H
T
E
R
F
D
P
C
R
Site 114
S769
R
P
Q
L
Q
P
G
S
P
S
L
V
S
E
E
Site 115
S771
Q
L
Q
P
G
S
P
S
L
V
S
E
E
S
P
Site 116
S774
P
G
S
P
S
L
V
S
E
E
S
P
S
A
I
Site 117
S777
P
S
L
V
S
E
E
S
P
S
A
I
D
S
D
Site 118
S779
L
V
S
E
E
S
P
S
A
I
D
S
D
K
M
Site 119
S783
E
S
P
S
A
I
D
S
D
K
M
S
D
L
G
Site 120
S787
A
I
D
S
D
K
M
S
D
L
G
G
R
K
P
Site 121
S800
K
P
P
G
N
V
I
S
V
I
Q
H
T
N
S
Site 122
T805
V
I
S
V
I
Q
H
T
N
S
L
S
R
P
N
Site 123
S807
S
V
I
Q
H
T
N
S
L
S
R
P
N
S
F
Site 124
S809
I
Q
H
T
N
S
L
S
R
P
N
S
F
E
R
Site 125
S813
N
S
L
S
R
P
N
S
F
E
R
S
E
S
A
Site 126
S817
R
P
N
S
F
E
R
S
E
S
A
E
L
V
A
Site 127
S819
N
S
F
E
R
S
E
S
A
E
L
V
A
C
T
Site 128
S832
C
T
Q
D
K
A
P
S
P
S
E
T
C
D
S
Site 129
T836
K
A
P
S
P
S
E
T
C
D
S
E
I
S
E
Site 130
S839
S
P
S
E
T
C
D
S
E
I
S
E
A
P
V
Site 131
S842
E
T
C
D
S
E
I
S
E
A
P
V
S
P
E
Site 132
S847
E
I
S
E
A
P
V
S
P
E
W
A
P
P
G
Site 133
S859
P
P
G
D
G
A
E
S
G
G
K
P
S
P
S
Site 134
S864
A
E
S
G
G
K
P
S
P
S
Q
Q
V
Q
Q
Site 135
S866
S
G
G
K
P
S
P
S
Q
Q
V
Q
Q
Q
S
Site 136
S873
S
Q
Q
V
Q
Q
Q
S
Y
H
T
Q
P
R
L
Site 137
T894
Q
V
P
E
I
R
V
T
E
E
P
D
K
P
E
Site 138
S908
E
K
E
K
E
A
Q
S
K
E
P
E
K
P
V
Site 139
S924
E
F
Q
W
P
Q
R
S
E
T
L
S
Q
L
P
Site 140
T926
Q
W
P
Q
R
S
E
T
L
S
Q
L
P
A
E
Site 141
S928
P
Q
R
S
E
T
L
S
Q
L
P
A
E
K
L
Site 142
S950
R
L
A
D
M
E
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T
P
S
D
S
C
E
D
T
Q
M
T
Site 295
T1993
P
S
D
S
C
E
D
T
Q
M
T
E
Y
Q
R
Site 296
T1996
S
C
E
D
T
Q
M
T
E
Y
Q
R
L
F
Q
Site 297
Y1998
E
D
T
Q
M
T
E
Y
Q
R
L
F
Q
S
K
Site 298
S2006
Q
R
L
F
Q
S
K
S
T
D
S
E
P
D
K
Site 299
S2009
F
Q
S
K
S
T
D
S
E
P
D
K
D
R
L
Site 300
S2030
D
E
E
C
M
L
P
S
E
P
S
S
S
P
R
Site 301
S2033
C
M
L
P
S
E
P
S
S
S
P
R
D
F
S
Site 302
S2034
M
L
P
S
E
P
S
S
S
P
R
D
F
S
P
Site 303
S2035
L
P
S
E
P
S
S
S
P
R
D
F
S
P
S
Site 304
S2040
S
S
S
P
R
D
F
S
P
S
S
H
H
S
S
Site 305
S2042
S
P
R
D
F
S
P
S
S
H
H
S
S
P
G
Site 306
S2043
P
R
D
F
S
P
S
S
H
H
S
S
P
G
Y
Site 307
S2046
F
S
P
S
S
H
H
S
S
P
G
Y
D
S
S
Site 308
S2047
S
P
S
S
H
H
S
S
P
G
Y
D
S
S
P
Site 309
Y2050
S
H
H
S
S
P
G
Y
D
S
S
P
C
R
D
Site 310
S2052
H
S
S
P
G
Y
D
S
S
P
C
R
D
N
S
Site 311
S2053
S
S
P
G
Y
D
S
S
P
C
R
D
N
S
P
Site 312
S2059
S
S
P
C
R
D
N
S
P
K
R
Y
L
I
P
Site 313
Y2063
R
D
N
S
P
K
R
Y
L
I
P
K
G
D
L
Site 314
S2071
L
I
P
K
G
D
L
S
P
R
R
H
L
S
P
Site 315
S2077
L
S
P
R
R
H
L
S
P
R
R
D
L
S
P
Site 316
S2083
L
S
P
R
R
D
L
S
P
M
R
H
L
S
P
Site 317
S2089
L
S
P
M
R
H
L
S
P
R
K
E
A
A
L
Site 318
S2101
A
A
L
R
R
E
M
S
Q
R
D
V
S
P
R
Site 319
S2106
E
M
S
Q
R
D
V
S
P
R
R
H
L
S
P
Site 320
S2112
V
S
P
R
R
H
L
S
P
R
R
P
V
S
P
Site 321
S2118
L
S
P
R
R
P
V
S
P
G
K
D
I
T
A
Site 322
T2124
V
S
P
G
K
D
I
T
A
R
R
D
L
S
P
Site 323
S2130
I
T
A
R
R
D
L
S
P
R
R
E
R
R
Y
Site 324
Y2137
S
P
R
R
E
R
R
Y
M
T
T
I
R
A
P
Site 325
T2139
R
R
E
R
R
Y
M
T
T
I
R
A
P
S
P
Site 326
T2140
R
E
R
R
Y
M
T
T
I
R
A
P
S
P
R
Site 327
S2145
M
T
T
I
R
A
P
S
P
R
R
A
L
Y
H
Site 328
Y2151
P
S
P
R
R
A
L
Y
H
N
P
P
L
S
M
Site 329
S2157
L
Y
H
N
P
P
L
S
M
G
Q
Y
L
Q
A
Site 330
Y2183
R
G
L
P
Q
V
P
Y
F
S
L
Y
G
D
Q
Site 331
S2185
L
P
Q
V
P
Y
F
S
L
Y
G
D
Q
E
G
Site 332
Y2187
Q
V
P
Y
F
S
L
Y
G
D
Q
E
G
A
Y
Site 333
Y2194
Y
G
D
Q
E
G
A
Y
E
H
P
G
S
S
L
Site 334
S2199
G
A
Y
E
H
P
G
S
S
L
F
P
E
G
P
Site 335
S2200
A
Y
E
H
P
G
S
S
L
F
P
E
G
P
N
Site 336
Y2209
F
P
E
G
P
N
D
Y
V
F
S
H
L
P
L
Site 337
S2212
G
P
N
D
Y
V
F
S
H
L
P
L
H
S
Q
Site 338
S2218
F
S
H
L
P
L
H
S
Q
Q
Q
V
R
A
P
Site 339
S2245
H
S
M
P
P
A
L
S
S
L
H
P
S
P
T
Site 340
S2246
S
M
P
P
A
L
S
S
L
H
P
S
P
T
L
Site 341
T2252
S
S
L
H
P
S
P
T
L
P
L
P
M
E
G
Site 342
S2270
K
K
G
A
S
G
E
S
F
S
K
D
P
Y
V
Site 343
S2272
G
A
S
G
E
S
F
S
K
D
P
Y
V
L
S
Site 344
Y2276
E
S
F
S
K
D
P
Y
V
L
S
K
Q
H
E
Site 345
S2279
S
K
D
P
Y
V
L
S
K
Q
H
E
K
R
G
Site 346
S2292
R
G
P
H
A
L
Q
S
S
G
P
P
S
T
P
Site 347
S2293
G
P
H
A
L
Q
S
S
G
P
P
S
T
P
S
Site 348
S2297
L
Q
S
S
G
P
P
S
T
P
S
S
P
R
L
Site 349
T2298
Q
S
S
G
P
P
S
T
P
S
S
P
R
L
L
Site 350
S2300
S
G
P
P
S
T
P
S
S
P
R
L
L
M
K
Site 351
S2301
G
P
P
S
T
P
S
S
P
R
L
L
M
K
Q
Site 352
S2309
P
R
L
L
M
K
Q
S
T
S
E
D
S
L
N
Site 353
T2310
R
L
L
M
K
Q
S
T
S
E
D
S
L
N
A
Site 354
S2311
L
L
M
K
Q
S
T
S
E
D
S
L
N
A
T
Site 355
S2314
K
Q
S
T
S
E
D
S
L
N
A
T
E
R
E
Site 356
T2318
S
E
D
S
L
N
A
T
E
R
E
Q
E
E
N
Site 357
T2328
E
Q
E
E
N
I
Q
T
C
T
K
A
I
A
S
Site 358
S2364
P
H
Q
N
P
L
G
S
A
H
V
S
I
R
H
Site 359
S2368
P
L
G
S
A
H
V
S
I
R
H
F
S
R
P
Site 360
S2373
H
V
S
I
R
H
F
S
R
P
E
P
G
Q
P
Site 361
T2382
P
E
P
G
Q
P
C
T
S
A
T
H
P
D
L
Site 362
S2400
E
K
D
N
F
G
T
S
Q
T
P
L
A
H
S
Site 363
T2402
D
N
F
G
T
S
Q
T
P
L
A
H
S
T
F
Site 364
S2407
S
Q
T
P
L
A
H
S
T
F
Y
S
K
S
C
Site 365
T2408
Q
T
P
L
A
H
S
T
F
Y
S
K
S
C
V
Site 366
S2411
L
A
H
S
T
F
Y
S
K
S
C
V
D
D
K
Site 367
S2413
H
S
T
F
Y
S
K
S
C
V
D
D
K
Q
L
Site 368
S2424
D
K
Q
L
D
F
H
S
S
K
E
L
S
S
S
Site 369
S2425
K
Q
L
D
F
H
S
S
K
E
L
S
S
S
T
Site 370
S2429
F
H
S
S
K
E
L
S
S
S
T
E
E
S
K
Site 371
S2430
H
S
S
K
E
L
S
S
S
T
E
E
S
K
D
Site 372
S2431
S
S
K
E
L
S
S
S
T
E
E
S
K
D
P
Site 373
T2432
S
K
E
L
S
S
S
T
E
E
S
K
D
P
S
Site 374
S2435
L
S
S
S
T
E
E
S
K
D
P
S
S
E
K
Site 375
S2439
T
E
E
S
K
D
P
S
S
E
K
S
Q
L
H
Site 376
S2440
E
E
S
K
D
P
S
S
E
K
S
Q
L
H
_
Site 377
S2443
K
D
P
S
S
E
K
S
Q
L
H
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation