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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SERT
Full Name:
Sodium-dependent serotonin transporter
Alias:
5HT transporter; 5HTT; 5-HTT; HTT; HTT, SERT; SC6A4; Serotonin transporter; SLC6A4; Solute carrier family 6 (neurotransmitter transporter, serotonin) member 4
Type:
Transport protein, active
Mass (Da):
70325
Number AA:
630
UniProt ID:
P31645
International Prot ID:
IPI00012472
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0008022
GO:0015222
GO:0005335
PhosphoSite+
KinaseNET
Biological Process:
GO:0009636
GO:0051610
GO:0021794
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
T
T
P
L
N
S
Q
K
Q
L
S
A
C
Site 2
S13
L
N
S
Q
K
Q
L
S
A
C
E
D
G
E
D
Site 3
T33
V
L
Q
K
V
V
P
T
P
G
D
K
V
E
S
Site 4
S40
T
P
G
D
K
V
E
S
G
Q
I
S
N
G
Y
Site 5
S44
K
V
E
S
G
Q
I
S
N
G
Y
S
A
V
P
Site 6
Y47
S
G
Q
I
S
N
G
Y
S
A
V
P
S
P
G
Site 7
S48
G
Q
I
S
N
G
Y
S
A
V
P
S
P
G
A
Site 8
S52
N
G
Y
S
A
V
P
S
P
G
A
G
D
D
T
Site 9
T59
S
P
G
A
G
D
D
T
R
H
S
I
P
A
T
Site 10
S62
A
G
D
D
T
R
H
S
I
P
A
T
T
T
T
Site 11
T66
T
R
H
S
I
P
A
T
T
T
T
L
V
A
E
Site 12
T81
L
H
Q
G
E
R
E
T
W
G
K
K
V
D
F
Site 13
Y142
M
E
L
A
L
G
Q
Y
H
R
N
G
C
I
S
Site 14
T276
S
I
W
K
G
V
K
T
S
G
K
V
V
W
V
Site 15
S277
I
W
K
G
V
K
T
S
G
K
V
V
W
V
T
Site 16
Y312
A
W
R
G
V
L
F
Y
L
K
P
N
W
Q
K
Site 17
S395
E
M
R
N
E
D
V
S
E
V
A
K
D
A
G
Site 18
Y568
P
Q
L
R
L
F
Q
Y
N
Y
P
Y
W
S
I
Site 19
S611
F
K
E
R
I
I
K
S
I
T
P
E
T
P
T
Site 20
T613
E
R
I
I
K
S
I
T
P
E
T
P
T
E
I
Site 21
T616
I
K
S
I
T
P
E
T
P
T
E
I
P
C
G
Site 22
T618
S
I
T
P
E
T
P
T
E
I
P
C
G
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation