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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATIC
Full Name:
Bifunctional purine biosynthesis protein PURH
Alias:
AICAR transformylase; AICARFT; Bifunctional purine biosynthesis protein; IMP synthetase; IMPCHASE; Inosinicase; Phosphoribosylaminoimidazolecarboxamide formyltransferase; Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PUR9; PURH
Type:
Cofactor and Vitamin Metabolism - one carbon pool by folate; Hydrolase; Methyltransferase; Nucleotide Metabolism - purine; EC 3.5.4.10; EC 2.1.2.3
Mass (Da):
64616
Number AA:
592
UniProt ID:
P31939
International Prot ID:
IPI00289499
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003937
GO:0004643
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0006189
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
Site 2
S34
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
Site 3
T37
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
Site 4
T67
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
Site 5
Y104
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
Site 6
T143
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Site 7
T156
E
D
Y
V
V
V
S
T
E
M
Q
S
S
E
S
Site 8
S161
V
S
T
E
M
Q
S
S
E
S
K
D
T
S
L
Site 9
S163
T
E
M
Q
S
S
E
S
K
D
T
S
L
E
T
Site 10
T166
Q
S
S
E
S
K
D
T
S
L
E
T
R
R
Q
Site 11
S167
S
S
E
S
K
D
T
S
L
E
T
R
R
Q
L
Site 12
Y185
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
Site 13
Y192
Y
D
E
A
I
S
D
Y
F
R
K
Q
Y
S
K
Site 14
Y197
S
D
Y
F
R
K
Q
Y
S
K
G
V
S
Q
M
Site 15
S198
D
Y
F
R
K
Q
Y
S
K
G
V
S
Q
M
P
Site 16
S202
K
Q
Y
S
K
G
V
S
Q
M
P
L
R
Y
G
Site 17
Y208
V
S
Q
M
P
L
R
Y
G
M
N
P
H
Q
T
Site 18
T215
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
T
L
Site 19
Y220
H
Q
T
P
A
Q
L
Y
T
L
Q
P
K
L
P
Site 20
T221
Q
T
P
A
Q
L
Y
T
L
Q
P
K
L
P
I
Site 21
Y290
E
A
K
V
C
M
V
Y
D
L
Y
K
T
L
T
Site 22
Y293
V
C
M
V
Y
D
L
Y
K
T
L
T
P
I
S
Site 23
T295
M
V
Y
D
L
Y
K
T
L
T
P
I
S
A
A
Site 24
S300
Y
K
T
L
T
P
I
S
A
A
Y
A
R
A
R
Site 25
Y303
L
T
P
I
S
A
A
Y
A
R
A
R
G
A
D
Site 26
S313
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
Site 27
S314
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
Site 28
T329
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
Site 29
T352
G
Y
E
E
E
A
L
T
I
L
S
K
K
K
N
Site 30
Y362
S
K
K
K
N
G
N
Y
C
V
L
Q
M
D
Q
Site 31
Y371
V
L
Q
M
D
Q
S
Y
K
P
D
E
N
E
V
Site 32
S387
T
L
F
G
L
H
L
S
Q
K
R
N
N
G
V
Site 33
T405
S
L
F
S
N
V
V
T
K
N
K
D
L
P
E
Site 34
S413
K
N
K
D
L
P
E
S
A
L
R
D
L
I
V
Site 35
Y464
L
A
G
D
K
A
N
Y
W
W
L
R
H
H
P
Site 36
S475
R
H
H
P
Q
V
L
S
M
K
F
K
T
G
V
Site 37
Y494
I
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
Site 38
T532
K
E
W
V
E
K
L
T
E
V
S
I
S
S
D
Site 39
Y558
A
K
R
S
G
V
A
Y
I
A
A
P
S
G
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation