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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INPP5B
Full Name:
Type II inositol-1,4,5-trisphosphate 5-phosphatase
Alias:
5PTase; 75 kDa inositol polyphosphate-5-phosphatase; EC 3.1.3.36; I5P2; Inositol polyphosphate-5-phosphatase, 75kDa; Phosphoinositide 5-phosphatase; Type II inositol-1,4,5-trisphosphate 5-phosphatase
Type:
EC 3.1.3.36; Phosphatase (non-protein); Carbohydrate Metabolism - inositol phosphate
Mass (Da):
112822
Number AA:
993
UniProt ID:
P32019
International Prot ID:
IPI00478376
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004445
GO:0004439
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
G
V
L
C
E
G
D
S
R
Q
S
R
L
L
G
Site 2
S33
C
E
G
D
S
R
Q
S
R
L
L
G
L
V
R
Site 3
Y41
R
L
L
G
L
V
R
Y
R
L
E
H
G
G
Q
Site 4
Y55
Q
E
H
A
L
F
L
Y
T
H
R
R
M
A
I
Site 5
T56
E
H
A
L
F
L
Y
T
H
R
R
M
A
I
T
Site 6
T63
T
H
R
R
M
A
I
T
G
D
D
V
S
L
D
Site 7
S76
L
D
Q
I
V
P
V
S
R
D
F
T
L
E
E
Site 8
T80
V
P
V
S
R
D
F
T
L
E
E
V
S
P
D
Site 9
S85
D
F
T
L
E
E
V
S
P
D
G
E
L
Y
I
Site 10
S134
R
A
C
P
G
F
D
S
A
T
R
D
P
E
F
Site 11
T136
C
P
G
F
D
S
A
T
R
D
P
E
F
L
W
Site 12
S145
D
P
E
F
L
W
L
S
R
Y
R
C
A
E
L
Site 13
Y147
E
F
L
W
L
S
R
Y
R
C
A
E
L
E
L
Site 14
T158
E
L
E
L
E
M
P
T
P
R
G
C
N
S
A
Site 15
Y180
A
T
I
G
G
G
R
Y
P
S
R
K
K
R
W
Site 16
S182
I
G
G
G
R
Y
P
S
R
K
K
R
W
G
L
Site 17
T210
W
G
G
A
M
E
K
T
G
F
R
L
M
E
R
Site 18
S228
G
G
F
V
W
G
R
S
A
R
D
G
R
R
D
Site 19
S246
E
E
A
G
R
E
M
S
A
A
A
G
S
R
E
Site 20
S251
E
M
S
A
A
A
G
S
R
E
R
N
T
A
G
Site 21
T256
A
G
S
R
E
R
N
T
A
G
G
S
N
F
D
Site 22
S260
E
R
N
T
A
G
G
S
N
F
D
G
L
R
P
Site 23
S277
K
G
V
P
M
D
Q
S
S
R
G
Q
D
K
P
Site 24
S286
R
G
Q
D
K
P
E
S
L
Q
P
R
Q
N
K
Site 25
S294
L
Q
P
R
Q
N
K
S
K
S
E
I
T
D
M
Site 26
S296
P
R
Q
N
K
S
K
S
E
I
T
D
M
V
R
Site 27
S305
I
T
D
M
V
R
S
S
T
I
T
V
S
D
K
Site 28
T306
T
D
M
V
R
S
S
T
I
T
V
S
D
K
A
Site 29
T308
M
V
R
S
S
T
I
T
V
S
D
K
A
H
I
Site 30
S310
R
S
S
T
I
T
V
S
D
K
A
H
I
L
S
Site 31
S317
S
D
K
A
H
I
L
S
M
Q
K
F
G
L
R
Site 32
T326
Q
K
F
G
L
R
D
T
I
V
K
S
H
L
L
Site 33
Y339
L
L
Q
K
E
E
D
Y
T
Y
I
Q
N
F
R
Site 34
Y341
Q
K
E
E
D
Y
T
Y
I
Q
N
F
R
F
F
Site 35
Y352
F
R
F
F
A
G
T
Y
N
V
N
G
Q
S
P
Site 36
S358
T
Y
N
V
N
G
Q
S
P
K
E
C
L
R
L
Site 37
S368
E
C
L
R
L
W
L
S
N
G
I
Q
A
P
D
Site 38
S387
G
F
Q
E
L
D
L
S
K
E
A
F
F
F
H
Site 39
Y416
G
L
H
P
D
A
K
Y
A
K
V
K
L
I
R
Site 40
Y440
V
K
Q
E
H
A
A
Y
I
S
E
V
E
A
E
Site 41
Y488
L
A
A
H
I
E
E
Y
E
R
R
N
Q
D
Y
Site 42
Y495
Y
E
R
R
N
Q
D
Y
K
D
I
C
S
R
M
Site 43
S510
Q
F
C
Q
P
D
P
S
L
P
P
L
T
I
S
Site 44
T515
D
P
S
L
P
P
L
T
I
S
N
H
D
V
I
Site 45
Y530
L
W
L
G
D
L
N
Y
R
I
E
E
L
D
V
Site 46
Y553
E
K
D
F
Q
M
L
Y
A
Y
D
Q
L
K
I
Site 47
T577
G
F
T
E
G
E
L
T
F
Q
P
T
Y
K
Y
Site 48
Y582
E
L
T
F
Q
P
T
Y
K
Y
D
T
G
S
D
Site 49
Y584
T
F
Q
P
T
Y
K
Y
D
T
G
S
D
D
W
Site 50
T586
Q
P
T
Y
K
Y
D
T
G
S
D
D
W
D
T
Site 51
S588
T
Y
K
Y
D
T
G
S
D
D
W
D
T
S
E
Site 52
T593
T
G
S
D
D
W
D
T
S
E
K
C
R
A
P
Site 53
S617
G
K
N
I
T
Q
L
S
Y
Q
S
H
M
A
L
Site 54
T626
Q
S
H
M
A
L
K
T
S
D
H
K
P
V
S
Site 55
S627
S
H
M
A
L
K
T
S
D
H
K
P
V
S
S
Site 56
S633
T
S
D
H
K
P
V
S
S
V
F
D
I
G
V
Site 57
S634
S
D
H
K
P
V
S
S
V
F
D
I
G
V
R
Site 58
Y648
R
V
V
N
D
E
L
Y
R
K
T
L
E
E
I
Site 59
T651
N
D
E
L
Y
R
K
T
L
E
E
I
V
R
S
Site 60
S658
T
L
E
E
I
V
R
S
L
D
K
M
E
N
A
Site 61
S669
M
E
N
A
N
I
P
S
V
S
L
S
K
R
E
Site 62
S671
N
A
N
I
P
S
V
S
L
S
K
R
E
F
C
Site 63
S673
N
I
P
S
V
S
L
S
K
R
E
F
C
F
Q
Site 64
Y684
F
C
F
Q
N
V
K
Y
M
Q
L
K
V
E
S
Site 65
S724
Q
W
L
N
A
N
P
S
R
G
F
L
L
P
D
Site 66
S732
R
G
F
L
L
P
D
S
D
V
E
I
D
L
E
Site 67
T745
L
E
L
F
V
N
K
T
T
A
T
K
L
N
S
Site 68
Y771
H
L
D
R
G
K
D
Y
F
L
S
V
S
G
N
Site 69
S774
R
G
K
D
Y
F
L
S
V
S
G
N
Y
L
P
Site 70
S776
K
D
Y
F
L
S
V
S
G
N
Y
L
P
S
C
Site 71
T790
C
F
G
S
P
I
H
T
L
C
Y
M
R
E
P
Site 72
Y793
S
P
I
H
T
L
C
Y
M
R
E
P
I
L
D
Site 73
S821
V
W
T
G
D
D
G
S
Q
L
D
S
P
M
E
Site 74
S825
D
D
G
S
Q
L
D
S
P
M
E
I
P
K
E
Site 75
Y839
E
L
W
M
M
V
D
Y
L
Y
R
N
A
V
Q
Site 76
Y841
W
M
M
V
D
Y
L
Y
R
N
A
V
Q
Q
E
Site 77
T869
H
I
R
D
C
L
D
T
G
M
I
D
N
L
S
Site 78
S876
T
G
M
I
D
N
L
S
A
S
N
H
S
V
A
Site 79
S878
M
I
D
N
L
S
A
S
N
H
S
V
A
E
A
Site 80
T914
L
E
C
S
G
N
Y
T
A
S
K
Q
V
I
S
Site 81
S916
C
S
G
N
Y
T
A
S
K
Q
V
I
S
T
L
Site 82
T922
A
S
K
Q
V
I
S
T
L
P
I
F
H
K
N
Site 83
Y933
F
H
K
N
V
F
H
Y
L
M
A
F
L
R
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation