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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARRB2
Full Name:
Beta-arrestin-2
Alias:
ARR2; Arrestin 3; Arrestin beta 2; Arrestin beta-2; Arrestin, beta 2; BARR2; DKFZp686L0365
Type:
Adaptor/scaffold
Mass (Da):
46106
Number AA:
409
UniProt ID:
P32121
International Prot ID:
IPI00180375
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031410
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0031623
GO:0050896
GO:0007600
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
G
E
K
P
G
T
R
V
F
K
K
S
S
Site 2
S13
G
T
R
V
F
K
K
S
S
P
N
C
K
L
T
Site 3
S14
T
R
V
F
K
K
S
S
P
N
C
K
L
T
V
Site 4
T20
S
S
P
N
C
K
L
T
V
Y
L
G
K
R
D
Site 5
Y22
P
N
C
K
L
T
V
Y
L
G
K
R
D
F
V
Site 6
Y48
V
V
L
V
D
P
D
Y
L
K
D
R
K
V
F
Site 7
T57
K
D
R
K
V
F
V
T
L
T
C
A
F
R
Y
Site 8
S75
D
L
D
V
L
G
L
S
F
R
K
D
L
F
I
Site 9
T99
P
N
P
P
R
P
P
T
R
L
Q
D
R
L
L
Site 10
S127
I
P
Q
N
L
P
C
S
V
T
L
Q
P
G
P
Site 11
T129
Q
N
L
P
C
S
V
T
L
Q
P
G
P
E
D
Site 12
S154
I
R
A
F
C
A
K
S
L
E
E
K
S
H
K
Site 13
S159
A
K
S
L
E
E
K
S
H
K
R
N
S
V
R
Site 14
S164
E
K
S
H
K
R
N
S
V
R
L
V
I
R
K
Site 15
S184
E
K
P
G
P
Q
P
S
A
E
T
T
R
H
F
Site 16
T187
G
P
Q
P
S
A
E
T
T
R
H
F
L
M
S
Site 17
T188
P
Q
P
S
A
E
T
T
R
H
F
L
M
S
D
Site 18
S194
T
T
R
H
F
L
M
S
D
R
S
L
H
L
E
Site 19
S197
H
F
L
M
S
D
R
S
L
H
L
E
A
S
L
Site 20
S203
R
S
L
H
L
E
A
S
L
D
K
E
L
Y
Y
Site 21
Y209
A
S
L
D
K
E
L
Y
Y
H
G
E
P
L
N
Site 22
Y210
S
L
D
K
E
L
Y
Y
H
G
E
P
L
N
V
Site 23
T228
V
T
N
N
S
T
K
T
V
K
K
I
K
V
S
Site 24
S235
T
V
K
K
I
K
V
S
V
R
Q
Y
A
D
I
Site 25
S264
L
E
Q
D
D
Q
V
S
P
S
S
T
F
C
K
Site 26
S266
Q
D
D
Q
V
S
P
S
S
T
F
C
K
V
Y
Site 27
S267
D
D
Q
V
S
P
S
S
T
F
C
K
V
Y
T
Site 28
T268
D
Q
V
S
P
S
S
T
F
C
K
V
Y
T
I
Site 29
T276
F
C
K
V
Y
T
I
T
P
L
L
S
D
N
R
Site 30
S280
Y
T
I
T
P
L
L
S
D
N
R
E
K
R
G
Site 31
T299
G
K
L
K
H
E
D
T
N
L
A
S
S
T
I
Site 32
S360
I
P
L
P
R
P
Q
S
A
A
P
E
T
D
V
Site 33
T365
P
Q
S
A
A
P
E
T
D
V
P
V
D
T
N
Site 34
T378
T
N
L
I
E
F
D
T
N
Y
A
T
D
D
D
Site 35
Y380
L
I
E
F
D
T
N
Y
A
T
D
D
D
I
V
Site 36
T382
E
F
D
T
N
Y
A
T
D
D
D
I
V
F
E
Site 37
Y404
K
G
M
K
D
D
D
Y
D
D
Q
L
C
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation