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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GBP2
Full Name:
Interferon-induced guanylate-binding protein 2
Alias:
GTP-binding protein 2;Guanine nucleotide-binding protein 2
Type:
Mass (Da):
67209
Number AA:
591
UniProt ID:
P32456
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
I
N
L
P
G
P
M
S
L
I
D
N
T
K
G
Site 2
S52
G
L
Y
R
T
G
K
S
Y
L
M
N
K
L
A
Site 3
Y53
L
Y
R
T
G
K
S
Y
L
M
N
K
L
A
G
Site 4
S66
A
G
K
K
N
G
F
S
L
G
S
T
V
K
S
Site 5
S69
K
N
G
F
S
L
G
S
T
V
K
S
H
T
K
Site 6
T70
N
G
F
S
L
G
S
T
V
K
S
H
T
K
G
Site 7
S73
S
L
G
S
T
V
K
S
H
T
K
G
I
W
M
Site 8
S130
S
S
T
F
V
Y
N
S
M
G
T
I
N
Q
Q
Site 9
Y144
Q
A
M
D
Q
L
H
Y
V
T
E
L
T
D
R
Site 10
T149
L
H
Y
V
T
E
L
T
D
R
I
K
A
N
S
Site 11
S156
T
D
R
I
K
A
N
S
S
P
G
N
N
S
V
Site 12
S157
D
R
I
K
A
N
S
S
P
G
N
N
S
V
D
Site 13
S162
N
S
S
P
G
N
N
S
V
D
D
S
A
D
F
Site 14
S166
G
N
N
S
V
D
D
S
A
D
F
V
S
F
F
Site 15
T195
E
V
D
G
E
P
I
T
A
D
D
Y
L
E
L
Site 16
Y199
E
P
I
T
A
D
D
Y
L
E
L
S
L
K
L
Site 17
S203
A
D
D
Y
L
E
L
S
L
K
L
R
K
G
T
Site 18
T210
S
L
K
L
R
K
G
T
D
K
K
S
K
S
F
Site 19
S214
R
K
G
T
D
K
K
S
K
S
F
N
D
P
R
Site 20
S216
G
T
D
K
K
S
K
S
F
N
D
P
R
L
C
Site 21
Y244
D
W
P
A
P
K
K
Y
L
A
H
L
E
Q
L
Site 22
S269
E
Q
V
A
E
F
C
S
Y
I
L
S
H
S
N
Site 23
S275
C
S
Y
I
L
S
H
S
N
V
K
T
L
S
G
Site 24
S281
H
S
N
V
K
T
L
S
G
G
I
P
V
N
G
Site 25
Y333
V
E
K
A
I
A
H
Y
E
Q
Q
M
G
Q
K
Site 26
S358
L
L
D
L
H
R
D
S
E
R
E
A
I
E
V
Site 27
S402
K
Q
N
S
K
A
S
S
D
C
C
M
A
L
L
Site 28
T424
E
E
D
V
K
Q
G
T
F
S
K
P
G
G
Y
Site 29
T435
P
G
G
Y
R
L
F
T
Q
K
L
Q
E
L
K
Site 30
Y445
L
Q
E
L
K
N
K
Y
Y
Q
V
P
R
K
G
Site 31
Y446
Q
E
L
K
N
K
Y
Y
Q
V
P
R
K
G
I
Site 32
Y462
A
K
E
V
L
K
K
Y
L
E
S
K
E
D
V
Site 33
S479
A
L
L
Q
T
D
Q
S
L
S
E
K
E
K
A
Site 34
S481
L
Q
T
D
Q
S
L
S
E
K
E
K
A
I
E
Site 35
S496
V
E
R
I
K
A
E
S
A
E
A
A
K
K
M
Site 36
T547
L
M
A
E
Q
E
K
T
L
A
L
K
L
Q
E
Site 37
S567
K
E
G
F
E
N
E
S
K
R
L
Q
K
D
I
Site 38
S583
D
I
Q
M
R
S
K
S
L
E
P
I
C
N
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation