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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GTF2H1
Full Name:
General transcription factor IIH subunit 1
Alias:
Basic transcription factor 62 kDa; BTF2; BTF2-p62; General transcription factor IIH polypeptide 1; General transcription factor IIH subunit 1; General transcription factor IIH, polypeptide 1, 62kDa; TF2H1; TFIIH
Type:
Transcription initiation complex
Mass (Da):
62032
Number AA:
548
UniProt ID:
P32780
International Prot ID:
IPI00030380
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005675
Uniprot
OncoNet
Molecular Function:
GO:0016251
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006368
GO:0000718
GO:0045944
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
K
K
Q
D
G
A
L
Y
L
M
A
E
R
I
A
Site 2
T42
P
E
G
K
D
R
F
T
I
S
H
M
Y
A
D
Site 3
Y47
R
F
T
I
S
H
M
Y
A
D
I
K
C
Q
K
Site 4
S56
D
I
K
C
Q
K
I
S
P
E
G
K
A
K
I
Site 5
T75
V
L
H
A
G
D
T
T
N
F
H
F
S
N
E
Site 6
T84
F
H
F
S
N
E
S
T
A
V
K
E
R
D
A
Site 7
T152
N
R
L
N
V
N
A
T
D
S
S
S
T
S
N
Site 8
S154
L
N
V
N
A
T
D
S
S
S
T
S
N
H
K
Site 9
S156
V
N
A
T
D
S
S
S
T
S
N
H
K
Q
D
Site 10
S158
A
T
D
S
S
S
T
S
N
H
K
Q
D
V
G
Site 11
T178
L
A
D
V
R
P
Q
T
D
G
C
N
G
L
R
Site 12
Y186
D
G
C
N
G
L
R
Y
N
L
T
S
D
I
I
Site 13
T189
N
G
L
R
Y
N
L
T
S
D
I
I
E
S
I
Site 14
Y200
I
E
S
I
F
R
T
Y
P
A
V
K
M
K
Y
Site 15
Y207
Y
P
A
V
K
M
K
Y
A
E
N
V
P
H
N
Site 16
Y229
T
R
F
F
Q
S
H
Y
F
H
R
D
R
L
N
Site 17
T237
F
H
R
D
R
L
N
T
G
S
K
D
L
F
A
Site 18
S239
R
D
R
L
N
T
G
S
K
D
L
F
A
E
C
Site 19
T270
K
N
P
L
L
D
L
T
A
L
E
D
K
P
L
Site 20
Y281
D
K
P
L
D
E
G
Y
G
I
S
S
V
P
S
Site 21
S284
L
D
E
G
Y
G
I
S
S
V
P
S
A
S
N
Site 22
S285
D
E
G
Y
G
I
S
S
V
P
S
A
S
N
S
Site 23
S288
Y
G
I
S
S
V
P
S
A
S
N
S
K
S
I
Site 24
S290
I
S
S
V
P
S
A
S
N
S
K
S
I
K
E
Site 25
S292
S
V
P
S
A
S
N
S
K
S
I
K
E
N
S
Site 26
S294
P
S
A
S
N
S
K
S
I
K
E
N
S
N
A
Site 27
T329
Q
E
A
Q
N
E
Q
T
S
E
P
S
N
M
D
Site 28
Y360
K
L
Q
E
S
I
E
Y
E
D
L
G
K
N
N
Site 29
S368
E
D
L
G
K
N
N
S
V
K
T
I
A
L
N
Site 30
S379
I
A
L
N
L
K
K
S
D
R
Y
Y
H
G
P
Site 31
Y382
N
L
K
K
S
D
R
Y
Y
H
G
P
T
P
I
Site 32
Y383
L
K
K
S
D
R
Y
Y
H
G
P
T
P
I
Q
Site 33
T387
D
R
Y
Y
H
G
P
T
P
I
Q
S
L
Q
Y
Site 34
S391
H
G
P
T
P
I
Q
S
L
Q
Y
A
T
S
Q
Site 35
S397
Q
S
L
Q
Y
A
T
S
Q
D
I
I
N
S
F
Site 36
S403
T
S
Q
D
I
I
N
S
F
Q
S
I
R
Q
E
Site 37
S406
D
I
I
N
S
F
Q
S
I
R
Q
E
M
E
A
Site 38
Y414
I
R
Q
E
M
E
A
Y
T
P
K
L
T
Q
V
Site 39
T415
R
Q
E
M
E
A
Y
T
P
K
L
T
Q
V
L
Site 40
T419
E
A
Y
T
P
K
L
T
Q
V
L
S
S
S
A
Site 41
S423
P
K
L
T
Q
V
L
S
S
S
A
A
S
S
T
Site 42
T483
W
S
C
F
P
V
N
T
P
F
L
E
E
K
V
Site 43
S495
E
K
V
V
K
M
K
S
N
L
E
R
F
Q
V
Site 44
Y516
Q
E
K
I
R
R
Q
Y
L
S
T
N
L
V
S
Site 45
S518
K
I
R
R
Q
Y
L
S
T
N
L
V
S
H
I
Site 46
T519
I
R
R
Q
Y
L
S
T
N
L
V
S
H
I
E
Site 47
Y533
E
E
M
L
Q
T
A
Y
N
K
L
H
T
W
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation