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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCC1
Full Name:
Multidrug resistance-associated protein 1
Alias:
ABC29; ABCC; ATP-binding cassette, sub-family C, member 1 multidrug resistance protein; GS-X; MRP; MRP1
Type:
Transporter protein; Membrane fraction, membrane, integral plasma membrane protein
Mass (Da):
171561
Number AA:
1531
UniProt ID:
P33527
International Prot ID:
IPI00014985
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042626
PhosphoSite+
KinaseNET
Biological Process:
GO:0042493
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y56
C
F
P
F
Y
F
L
Y
L
S
R
H
D
R
G
Site 2
Y64
L
S
R
H
D
R
G
Y
I
Q
M
T
P
L
N
Site 3
T68
D
R
G
Y
I
Q
M
T
P
L
N
K
T
K
T
Site 4
S134
E
R
R
K
G
V
Q
S
S
G
I
M
L
T
F
Site 5
S135
R
R
K
G
V
Q
S
S
G
I
M
L
T
F
W
Site 6
T159
I
L
R
S
K
I
M
T
A
L
K
E
D
A
Q
Site 7
S195
L
S
C
F
S
D
R
S
P
L
F
S
E
T
I
Site 8
S199
S
D
R
S
P
L
F
S
E
T
I
H
D
P
N
Site 9
S211
D
P
N
P
C
P
E
S
S
A
S
F
L
S
R
Site 10
S212
P
N
P
C
P
E
S
S
A
S
F
L
S
R
I
Site 11
S214
P
C
P
E
S
S
A
S
F
L
S
R
I
T
F
Site 12
Y232
T
G
L
I
V
R
G
Y
R
Q
P
L
E
G
S
Site 13
S239
Y
R
Q
P
L
E
G
S
D
L
W
S
L
N
K
Site 14
S243
L
E
G
S
D
L
W
S
L
N
K
E
D
T
S
Site 15
T249
W
S
L
N
K
E
D
T
S
E
Q
V
V
P
V
Site 16
S250
S
L
N
K
E
D
T
S
E
Q
V
V
P
V
L
Site 17
T268
W
K
K
E
C
A
K
T
R
K
Q
P
V
K
V
Site 18
Y277
K
Q
P
V
K
V
V
Y
S
S
K
D
P
A
Q
Site 19
S304
V
E
A
L
I
V
K
S
P
Q
K
E
W
N
P
Site 20
S312
P
Q
K
E
W
N
P
S
L
F
K
V
L
Y
K
Site 21
T356
L
I
K
F
V
N
D
T
K
A
P
D
W
Q
G
Site 22
S413
K
A
L
V
I
T
N
S
A
R
K
S
S
T
V
Site 23
S417
I
T
N
S
A
R
K
S
S
T
V
G
E
I
V
Site 24
S418
T
N
S
A
R
K
S
S
T
V
G
E
I
V
N
Site 25
T419
N
S
A
R
K
S
S
T
V
G
E
I
V
N
L
Site 26
Y490
M
A
M
K
T
K
T
Y
Q
V
A
H
M
K
S
Site 27
S610
I
S
S
I
V
Q
A
S
V
S
L
K
R
L
R
Site 28
S621
K
R
L
R
I
F
L
S
H
E
E
L
E
P
D
Site 29
S629
H
E
E
L
E
P
D
S
I
E
R
R
P
V
K
Site 30
S643
K
D
G
G
G
T
N
S
I
T
V
R
N
A
T
Site 31
T645
G
G
G
T
N
S
I
T
V
R
N
A
T
F
T
Site 32
T650
S
I
T
V
R
N
A
T
F
T
W
A
R
S
D
Site 33
T652
T
V
R
N
A
T
F
T
W
A
R
S
D
P
P
Site 34
S656
A
T
F
T
W
A
R
S
D
P
P
T
L
N
G
Site 35
T660
W
A
R
S
D
P
P
T
L
N
G
I
T
F
S
Site 36
Y736
G
C
Q
L
E
E
P
Y
Y
R
S
V
I
Q
A
Site 37
Y737
C
Q
L
E
E
P
Y
Y
R
S
V
I
Q
A
C
Site 38
S755
P
D
L
E
I
L
P
S
G
D
R
T
E
I
G
Site 39
T759
I
L
P
S
G
D
R
T
E
I
G
E
K
G
V
Site 40
S769
G
E
K
G
V
N
L
S
G
G
Q
K
Q
R
V
Site 41
S777
G
G
Q
K
Q
R
V
S
L
A
R
A
V
Y
S
Site 42
Y789
V
Y
S
N
A
D
I
Y
L
F
D
D
P
L
S
Site 43
T821
K
G
M
L
K
N
K
T
R
I
L
V
T
H
S
Site 44
T826
N
K
T
R
I
L
V
T
H
S
M
S
Y
L
P
Site 45
S847
V
M
S
G
G
K
I
S
E
M
G
S
Y
Q
E
Site 46
S851
G
K
I
S
E
M
G
S
Y
Q
E
L
L
A
R
Site 47
Y852
K
I
S
E
M
G
S
Y
Q
E
L
L
A
R
D
Site 48
T868
A
F
A
E
F
L
R
T
Y
A
S
T
E
Q
E
Site 49
Y869
F
A
E
F
L
R
T
Y
A
S
T
E
Q
E
Q
Site 50
S871
E
F
L
R
T
Y
A
S
T
E
Q
E
Q
D
A
Site 51
T884
D
A
E
E
N
G
V
T
G
V
S
G
P
G
K
Site 52
S905
N
G
M
L
V
T
D
S
A
G
K
Q
L
Q
R
Site 53
S915
K
Q
L
Q
R
Q
L
S
S
S
S
S
Y
S
G
Site 54
S916
Q
L
Q
R
Q
L
S
S
S
S
S
Y
S
G
D
Site 55
S917
L
Q
R
Q
L
S
S
S
S
S
Y
S
G
D
I
Site 56
S918
Q
R
Q
L
S
S
S
S
S
Y
S
G
D
I
S
Site 57
S919
R
Q
L
S
S
S
S
S
Y
S
G
D
I
S
R
Site 58
Y920
Q
L
S
S
S
S
S
Y
S
G
D
I
S
R
H
Site 59
S921
L
S
S
S
S
S
Y
S
G
D
I
S
R
H
H
Site 60
S925
S
S
Y
S
G
D
I
S
R
H
H
N
S
T
A
Site 61
S930
D
I
S
R
H
H
N
S
T
A
E
L
Q
K
A
Site 62
T931
I
S
R
H
H
N
S
T
A
E
L
Q
K
A
E
Site 63
Y963
G
Q
V
K
L
S
V
Y
W
D
Y
M
K
A
I
Site 64
T1012
V
N
G
T
Q
E
H
T
K
V
R
L
S
V
Y
Site 65
S1062
S
I
L
R
S
P
M
S
F
F
E
R
T
P
S
Site 66
T1067
P
M
S
F
F
E
R
T
P
S
G
N
L
V
N
Site 67
S1069
S
F
F
E
R
T
P
S
G
N
L
V
N
R
F
Site 68
S1077
G
N
L
V
N
R
F
S
K
E
L
D
T
V
D
Site 69
T1082
R
F
S
K
E
L
D
T
V
D
S
M
I
P
E
Site 70
S1085
K
E
L
D
T
V
D
S
M
I
P
E
V
I
K
Site 71
S1136
V
Q
R
F
Y
V
A
S
S
R
Q
L
K
R
L
Site 72
S1145
R
Q
L
K
R
L
E
S
V
S
R
S
P
V
Y
Site 73
S1147
L
K
R
L
E
S
V
S
R
S
P
V
Y
S
H
Site 74
S1149
R
L
E
S
V
S
R
S
P
V
Y
S
H
F
N
Site 75
Y1152
S
V
S
R
S
P
V
Y
S
H
F
N
E
T
L
Site 76
S1153
V
S
R
S
P
V
Y
S
H
F
N
E
T
L
L
Site 77
S1178
Q
E
R
F
I
H
Q
S
D
L
K
V
D
E
N
Site 78
Y1190
D
E
N
Q
K
A
Y
Y
P
S
I
V
A
N
R
Site 79
Y1243
Y
S
L
Q
V
T
T
Y
L
N
W
L
V
R
M
Site 80
S1252
N
W
L
V
R
M
S
S
E
M
E
T
N
I
V
Site 81
T1256
R
M
S
S
E
M
E
T
N
I
V
A
V
E
R
Site 82
S1268
V
E
R
L
K
E
Y
S
E
T
E
K
E
A
P
Site 83
T1270
R
L
K
E
Y
S
E
T
E
K
E
A
P
W
Q
Site 84
T1281
A
P
W
Q
I
Q
E
T
A
P
P
S
S
W
P
Site 85
S1285
I
Q
E
T
A
P
P
S
S
W
P
Q
V
G
R
Site 86
S1286
Q
E
T
A
P
P
S
S
W
P
Q
V
G
R
V
Site 87
Y1298
G
R
V
E
F
R
N
Y
C
L
R
Y
R
E
D
Site 88
S1335
R
T
G
A
G
K
S
S
L
T
L
G
L
F
R
Site 89
T1371
H
D
L
R
F
K
I
T
I
I
P
Q
D
P
V
Site 90
S1381
P
Q
D
P
V
L
F
S
G
S
L
R
M
N
L
Site 91
S1383
D
P
V
L
F
S
G
S
L
R
M
N
L
D
P
Site 92
S1392
R
M
N
L
D
P
F
S
Q
Y
S
D
E
E
V
Site 93
S1395
L
D
P
F
S
Q
Y
S
D
E
E
V
W
T
S
Site 94
T1401
Y
S
D
E
E
V
W
T
S
L
E
L
A
H
L
Site 95
S1402
S
D
E
E
V
W
T
S
L
E
L
A
H
L
K
Site 96
S1413
A
H
L
K
D
F
V
S
A
L
P
D
K
L
D
Site 97
S1431
A
E
G
G
E
N
L
S
V
G
Q
R
Q
L
V
Site 98
T1474
L
I
Q
S
T
I
R
T
Q
F
E
D
C
T
V
Site 99
T1480
R
T
Q
F
E
D
C
T
V
L
T
I
A
H
R
Site 100
T1490
T
I
A
H
R
L
N
T
I
M
D
Y
T
R
V
Site 101
Y1508
D
K
G
E
I
Q
E
Y
G
A
P
S
D
L
L
Site 102
Y1522
L
Q
Q
R
G
L
F
Y
S
M
A
K
D
A
G
Site 103
S1523
Q
Q
R
G
L
F
Y
S
M
A
K
D
A
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation