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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCM4
Full Name:
DNA replication licensing factor MCM4
Alias:
CDC21; CDC54; DNA replication licensing factor MCM4; MGC33310; Minichromosome maintenance complex component 4; P1-CDC21
Type:
DNA replication protein
Mass (Da):
96558
Number AA:
863
UniProt ID:
P33991
International Prot ID:
IPI00018349
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006270
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
P
A
S
T
P
S
Site 2
S3
_
_
_
_
_
M
S
S
P
A
S
T
P
S
R
Site 3
S6
_
_
M
S
S
P
A
S
T
P
S
R
R
G
S
Site 4
T7
_
M
S
S
P
A
S
T
P
S
R
R
G
S
R
Site 5
S9
S
S
P
A
S
T
P
S
R
R
G
S
R
R
G
Site 6
S13
S
T
P
S
R
R
G
S
R
R
G
R
A
T
P
Site 7
T19
G
S
R
R
G
R
A
T
P
A
Q
T
P
R
S
Site 8
T23
G
R
A
T
P
A
Q
T
P
R
S
E
D
A
R
Site 9
S26
T
P
A
Q
T
P
R
S
E
D
A
R
S
S
P
Site 10
S31
P
R
S
E
D
A
R
S
S
P
S
Q
R
R
R
Site 11
S32
R
S
E
D
A
R
S
S
P
S
Q
R
R
R
G
Site 12
S34
E
D
A
R
S
S
P
S
Q
R
R
R
G
E
D
Site 13
S42
Q
R
R
R
G
E
D
S
T
S
T
G
E
L
Q
Site 14
T43
R
R
R
G
E
D
S
T
S
T
G
E
L
Q
P
Site 15
S44
R
R
G
E
D
S
T
S
T
G
E
L
Q
P
M
Site 16
T53
G
E
L
Q
P
M
P
T
S
P
G
V
D
L
Q
Site 17
S54
E
L
Q
P
M
P
T
S
P
G
V
D
L
Q
S
Site 18
S61
S
P
G
V
D
L
Q
S
P
A
A
Q
D
V
L
Site 19
S70
A
A
Q
D
V
L
F
S
S
P
P
Q
M
H
S
Site 20
S71
A
Q
D
V
L
F
S
S
P
P
Q
M
H
S
S
Site 21
S77
S
S
P
P
Q
M
H
S
S
A
I
P
L
D
F
Site 22
S78
S
P
P
Q
M
H
S
S
A
I
P
L
D
F
D
Site 23
S87
I
P
L
D
F
D
V
S
S
P
L
T
Y
G
T
Site 24
S88
P
L
D
F
D
V
S
S
P
L
T
Y
G
T
P
Site 25
T91
F
D
V
S
S
P
L
T
Y
G
T
P
S
S
R
Site 26
Y92
D
V
S
S
P
L
T
Y
G
T
P
S
S
R
V
Site 27
T94
S
S
P
L
T
Y
G
T
P
S
S
R
V
E
G
Site 28
S96
P
L
T
Y
G
T
P
S
S
R
V
E
G
T
P
Site 29
S97
L
T
Y
G
T
P
S
S
R
V
E
G
T
P
R
Site 30
T102
P
S
S
R
V
E
G
T
P
R
S
G
V
R
G
Site 31
S105
R
V
E
G
T
P
R
S
G
V
R
G
T
P
V
Site 32
T110
P
R
S
G
V
R
G
T
P
V
R
Q
R
P
D
Site 33
S120
R
Q
R
P
D
L
G
S
A
Q
K
G
L
Q
V
Site 34
S131
G
L
Q
V
D
L
Q
S
D
G
A
A
A
E
D
Site 35
S142
A
A
E
D
I
V
A
S
E
Q
S
L
G
Q
K
Site 36
S145
D
I
V
A
S
E
Q
S
L
G
Q
K
L
V
I
Site 37
T189
E
N
V
G
I
D
I
T
E
P
L
Y
M
Q
R
Site 38
Y193
I
D
I
T
E
P
L
Y
M
Q
R
L
G
E
I
Site 39
Y223
K
S
F
D
K
N
L
Y
R
Q
L
I
S
Y
P
Site 40
Y229
L
Y
R
Q
L
I
S
Y
P
Q
E
V
I
P
T
Site 41
T236
Y
P
Q
E
V
I
P
T
F
D
M
A
V
N
E
Site 42
Y249
N
E
I
F
F
D
R
Y
P
D
S
I
L
E
H
Site 43
S293
S
G
M
V
I
R
T
S
Q
L
I
P
E
M
Q
Site 44
S326
R
G
R
I
A
E
P
S
V
C
G
R
C
H
T
Site 45
S344
M
A
L
I
H
N
R
S
L
F
S
D
K
Q
M
Site 46
S357
Q
M
I
K
L
Q
E
S
P
E
D
M
P
A
G
Site 47
T366
E
D
M
P
A
G
Q
T
P
H
T
V
I
L
F
Site 48
T369
P
A
G
Q
T
P
H
T
V
I
L
F
A
H
N
Site 49
Y394
R
V
N
V
T
G
I
Y
R
A
V
P
I
R
V
Site 50
S406
I
R
V
N
P
R
V
S
N
V
K
S
V
Y
K
Site 51
S410
P
R
V
S
N
V
K
S
V
Y
K
T
H
I
D
Site 52
T424
D
V
I
H
Y
R
K
T
D
A
K
R
L
H
G
Site 53
S453
V
E
L
L
K
E
L
S
R
K
P
D
I
Y
E
Site 54
Y459
L
S
R
K
P
D
I
Y
E
R
L
A
S
A
L
Site 55
S464
D
I
Y
E
R
L
A
S
A
L
A
P
S
I
Y
Site 56
S469
L
A
S
A
L
A
P
S
I
Y
E
H
E
D
I
Site 57
Y471
S
A
L
A
P
S
I
Y
E
H
E
D
I
K
K
Site 58
S493
G
G
T
R
K
D
F
S
H
T
G
R
G
K
F
Site 59
T495
T
R
K
D
F
S
H
T
G
R
G
K
F
R
A
Site 60
T514
L
L
C
G
D
P
G
T
S
K
S
Q
L
L
Q
Site 61
S515
L
C
G
D
P
G
T
S
K
S
Q
L
L
Q
Y
Site 62
S517
G
D
P
G
T
S
K
S
Q
L
L
Q
Y
V
Y
Site 63
Y522
S
K
S
Q
L
L
Q
Y
V
Y
N
L
V
P
R
Site 64
Y524
S
Q
L
L
Q
Y
V
Y
N
L
V
P
R
G
Q
Site 65
Y532
N
L
V
P
R
G
Q
Y
T
S
G
K
G
S
S
Site 66
S534
V
P
R
G
Q
Y
T
S
G
K
G
S
S
A
V
Site 67
S538
Q
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Site 68
S539
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Y
Site 69
Y546
S
A
V
G
L
T
A
Y
V
M
K
D
P
E
T
Site 70
S582
E
F
D
K
M
N
E
S
T
R
S
V
L
H
E
Site 71
S585
K
M
N
E
S
T
R
S
V
L
H
E
V
M
E
Site 72
T639
E
N
I
Q
L
P
H
T
L
L
S
R
F
D
L
Site 73
Y658
L
D
P
Q
D
E
A
Y
D
R
R
L
A
H
H
Site 74
Y670
A
H
H
L
V
A
L
Y
Y
Q
S
E
E
Q
A
Site 75
Y671
H
H
L
V
A
L
Y
Y
Q
S
E
E
Q
A
E
Site 76
T697
Y
I
A
Y
A
H
S
T
I
M
P
R
L
S
E
Site 77
S703
S
T
I
M
P
R
L
S
E
E
A
S
Q
A
L
Site 78
S707
P
R
L
S
E
E
A
S
Q
A
L
I
E
A
Y
Site 79
Y714
S
Q
A
L
I
E
A
Y
V
D
M
R
K
I
G
Site 80
S722
V
D
M
R
K
I
G
S
S
R
G
M
V
S
A
Site 81
S723
D
M
R
K
I
G
S
S
R
G
M
V
S
A
Y
Site 82
S728
G
S
S
R
G
M
V
S
A
Y
P
R
Q
L
E
Site 83
Y730
S
R
G
M
V
S
A
Y
P
R
Q
L
E
S
L
Site 84
S736
A
Y
P
R
Q
L
E
S
L
I
R
L
A
E
A
Site 85
S750
A
H
A
K
V
R
L
S
N
K
V
E
A
I
D
Site 86
T774
E
A
L
K
Q
S
A
T
D
P
R
T
G
I
V
Site 87
T778
Q
S
A
T
D
P
R
T
G
I
V
D
I
S
I
Site 88
S784
R
T
G
I
V
D
I
S
I
L
T
T
G
M
S
Site 89
T788
V
D
I
S
I
L
T
T
G
M
S
A
T
S
R
Site 90
S791
S
I
L
T
T
G
M
S
A
T
S
R
K
R
K
Site 91
T815
L
I
L
S
K
G
K
T
P
A
L
K
Y
Q
Q
Site 92
Y820
G
K
T
P
A
L
K
Y
Q
Q
L
F
E
D
I
Site 93
S831
F
E
D
I
R
G
Q
S
D
I
A
I
T
K
D
Site 94
T854
L
A
D
D
D
F
L
T
V
T
G
K
T
V
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation