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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCM5
Full Name:
DNA replication licensing factor MCM5
Alias:
CDC46; CDC46 homologue; DNA replication licensing factor MCM5; Minichromosome maintenance complex component 5
Type:
Cell cycle regulation
Mass (Da):
82286
Number AA:
734
UniProt ID:
P33992
International Prot ID:
IPI00018350
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006270
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
F
D
D
P
G
I
Site 2
Y11
F
D
D
P
G
I
F
Y
S
D
S
F
G
G
D
Site 3
S12
D
D
P
G
I
F
Y
S
D
S
F
G
G
D
A
Site 4
S14
P
G
I
F
Y
S
D
S
F
G
G
D
A
Q
A
Site 5
S29
D
E
G
Q
A
R
K
S
Q
L
Q
R
R
F
K
Site 6
Y42
F
K
E
F
L
R
Q
Y
R
V
G
T
D
R
T
Site 7
T46
L
R
Q
Y
R
V
G
T
D
R
T
G
F
T
F
Site 8
T52
G
T
D
R
T
G
F
T
F
K
Y
R
D
E
L
Site 9
Y55
R
T
G
F
T
F
K
Y
R
D
E
L
K
R
H
Site 10
Y63
R
D
E
L
K
R
H
Y
N
L
G
E
Y
W
I
Site 11
Y68
R
H
Y
N
L
G
E
Y
W
I
E
V
E
M
E
Site 12
S79
V
E
M
E
D
L
A
S
F
D
E
D
L
A
D
Site 13
Y87
F
D
E
D
L
A
D
Y
L
Y
K
Q
P
A
E
Site 14
Y89
E
D
L
A
D
Y
L
Y
K
Q
P
A
E
H
L
Site 15
S116
E
V
T
R
P
R
P
S
G
E
E
V
L
Q
D
Site 16
S130
D
I
Q
V
M
L
K
S
D
A
S
P
S
S
I
Site 17
S133
V
M
L
K
S
D
A
S
P
S
S
I
R
S
L
Site 18
S135
L
K
S
D
A
S
P
S
S
I
R
S
L
K
S
Site 19
S136
K
S
D
A
S
P
S
S
I
R
S
L
K
S
D
Site 20
S139
A
S
P
S
S
I
R
S
L
K
S
D
M
M
S
Site 21
S142
S
S
I
R
S
L
K
S
D
M
M
S
H
L
V
Site 22
S146
S
L
K
S
D
M
M
S
H
L
V
K
I
P
G
Site 23
S159
P
G
I
I
I
A
A
S
A
V
R
A
K
A
T
Site 24
S169
R
A
K
A
T
R
I
S
I
Q
C
R
S
C
R
Site 25
T180
R
S
C
R
N
T
L
T
N
I
A
M
R
P
G
Site 26
Y191
M
R
P
G
L
E
G
Y
A
L
P
R
K
C
N
Site 27
Y212
P
K
C
P
L
D
P
Y
F
I
M
P
D
K
C
Site 28
Y248
M
P
R
H
M
Q
L
Y
C
D
R
Y
L
C
D
Site 29
Y252
M
Q
L
Y
C
D
R
Y
L
C
D
K
V
V
P
Site 30
Y269
R
V
T
I
M
G
I
Y
S
I
K
K
F
G
L
Site 31
T277
S
I
K
K
F
G
L
T
T
S
R
G
R
D
R
Site 32
S279
K
K
F
G
L
T
T
S
R
G
R
D
R
V
G
Site 33
S306
I
Q
V
D
T
D
G
S
G
R
S
F
A
G
A
Site 34
S309
D
T
D
G
S
G
R
S
F
A
G
A
V
S
P
Site 35
S315
R
S
F
A
G
A
V
S
P
Q
E
E
E
E
F
Site 36
Y332
L
A
A
L
P
N
V
Y
E
V
I
S
K
S
I
Site 37
S342
I
S
K
S
I
A
P
S
I
F
G
G
T
D
M
Site 38
S361
A
C
L
L
F
G
G
S
R
K
R
L
P
D
G
Site 39
T370
K
R
L
P
D
G
L
T
R
R
G
D
I
N
L
Site 40
T385
L
M
L
G
D
P
G
T
A
K
S
Q
L
L
K
Site 41
S388
G
D
P
G
T
A
K
S
Q
L
L
K
F
V
E
Site 42
Y403
K
C
S
P
I
G
V
Y
T
S
G
K
G
S
S
Site 43
S405
S
P
I
G
V
Y
T
S
G
K
G
S
S
A
A
Site 44
S417
S
A
A
G
L
T
A
S
V
M
R
D
P
S
S
Site 45
S423
A
S
V
M
R
D
P
S
S
R
N
F
I
M
E
Site 46
S424
S
V
M
R
D
P
S
S
R
N
F
I
M
E
G
Site 47
Y565
K
L
K
K
F
I
A
Y
C
R
V
K
C
G
P
Site 48
S575
V
K
C
G
P
R
L
S
A
E
A
A
E
K
L
Site 49
S591
N
R
Y
I
I
M
R
S
G
A
R
Q
H
E
R
Site 50
S600
A
R
Q
H
E
R
D
S
D
R
R
S
S
I
P
Site 51
S604
E
R
D
S
D
R
R
S
S
I
P
I
T
V
R
Site 52
S605
R
D
S
D
R
R
S
S
I
P
I
T
V
R
Q
Site 53
T609
R
R
S
S
I
P
I
T
V
R
Q
L
E
A
I
Site 54
S665
S
G
V
E
G
F
T
S
Q
E
D
Q
E
M
L
Site 55
S673
Q
E
D
Q
E
M
L
S
R
I
E
K
Q
L
K
Site 56
S687
K
R
R
F
A
I
G
S
Q
V
S
E
H
S
I
Site 57
T699
H
S
I
I
K
D
F
T
K
Q
K
Y
P
E
H
Site 58
Y703
K
D
F
T
K
Q
K
Y
P
E
H
A
I
H
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation