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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RYK
Full Name:
Tyrosine-protein kinase RYK
Alias:
Type:
Mass (Da):
67507
Number AA:
604
UniProt ID:
P34925
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
R
L
G
R
P
G
R
S
C
L
P
G
P
A
L
Site 2
T200
K
K
L
E
E
V
K
T
S
A
L
D
K
N
T
Site 3
S208
S
A
L
D
K
N
T
S
R
T
I
Y
D
P
V
Site 4
T221
P
V
H
A
A
P
T
T
S
T
R
V
F
Y
I
Site 5
S260
K
R
I
E
L
D
D
S
I
S
A
S
S
S
S
Site 6
S262
I
E
L
D
D
S
I
S
A
S
S
S
S
Q
G
Site 7
S264
L
D
D
S
I
S
A
S
S
S
S
Q
G
L
S
Site 8
S265
D
D
S
I
S
A
S
S
S
S
Q
G
L
S
Q
Site 9
S266
D
S
I
S
A
S
S
S
S
Q
G
L
S
Q
P
Site 10
S267
S
I
S
A
S
S
S
S
Q
G
L
S
Q
P
S
Site 11
S271
S
S
S
S
Q
G
L
S
Q
P
S
T
Q
T
T
Site 12
S274
S
Q
G
L
S
Q
P
S
T
Q
T
T
Q
Y
L
Site 13
T275
Q
G
L
S
Q
P
S
T
Q
T
T
Q
Y
L
R
Site 14
T278
S
Q
P
S
T
Q
T
T
Q
Y
L
R
A
D
T
Site 15
Y280
P
S
T
Q
T
T
Q
Y
L
R
A
D
T
P
N
Site 16
T285
T
Q
Y
L
R
A
D
T
P
N
N
A
T
P
I
Site 17
T290
A
D
T
P
N
N
A
T
P
I
T
S
Y
P
T
Site 18
T293
P
N
N
A
T
P
I
T
S
Y
P
T
L
R
I
Site 19
Y295
N
A
T
P
I
T
S
Y
P
T
L
R
I
E
K
Site 20
S307
I
E
K
N
D
L
R
S
V
T
L
L
E
A
K
Site 21
T309
K
N
D
L
R
S
V
T
L
L
E
A
K
G
K
Site 22
S323
K
V
K
D
I
A
I
S
R
E
R
I
T
L
K
Site 23
T328
A
I
S
R
E
R
I
T
L
K
D
V
L
Q
E
Site 24
T337
K
D
V
L
Q
E
G
T
F
G
R
I
F
H
G
Site 25
T362
E
K
Q
A
F
V
K
T
V
K
D
Q
A
S
E
Site 26
S368
K
T
V
K
D
Q
A
S
E
I
Q
V
T
M
M
Site 27
T373
Q
A
S
E
I
Q
V
T
M
M
L
T
E
S
C
Site 28
T377
I
Q
V
T
M
M
L
T
E
S
C
K
L
R
G
Site 29
S379
V
T
M
M
L
T
E
S
C
K
L
R
G
L
H
Site 30
T394
H
R
N
L
L
P
I
T
H
V
C
I
E
E
G
Site 31
Y410
K
P
M
V
I
L
P
Y
M
N
W
G
N
L
K
Site 32
S435
A
N
N
P
Q
A
I
S
Q
Q
D
L
V
H
M
Site 33
T473
R
N
C
V
I
D
D
T
L
Q
V
K
I
T
D
Site 34
T479
D
T
L
Q
V
K
I
T
D
N
A
L
S
R
D
Site 35
S484
K
I
T
D
N
A
L
S
R
D
L
F
P
M
D
Site 36
Y492
R
D
L
F
P
M
D
Y
H
C
L
G
D
N
E
Site 37
S510
V
R
W
M
A
L
E
S
L
V
N
N
E
F
S
Site 38
T538
E
L
M
T
L
G
Q
T
P
Y
V
D
I
D
P
Site 39
Y540
M
T
L
G
Q
T
P
Y
V
D
I
D
P
F
E
Site 40
Y551
D
P
F
E
M
A
A
Y
L
K
D
G
Y
R
I
Site 41
Y556
A
A
Y
L
K
D
G
Y
R
I
A
Q
P
I
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation