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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSPA4
Full Name:
Heat shock 70 kDa protein 4
Alias:
APG2; Heat shock 70-related protein APG-2
Type:
Chaperone protein
Mass (Da):
94331
Number AA:
840
UniProt ID:
P34932
International Prot ID:
IPI00002966
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
GO:0034619
GO:0070096
GO:0006986
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T35
N
E
Y
S
D
R
C
T
P
A
C
I
S
F
G
Site 2
S40
R
C
T
P
A
C
I
S
F
G
P
K
N
R
S
Site 3
S47
S
F
G
P
K
N
R
S
I
G
A
A
A
K
S
Site 4
S54
S
I
G
A
A
A
K
S
Q
V
I
S
N
A
K
Site 5
S58
A
A
K
S
Q
V
I
S
N
A
K
N
T
V
Q
Site 6
S76
R
F
H
G
R
A
F
S
D
P
F
V
E
A
E
Site 7
Y89
A
E
K
S
N
L
A
Y
D
I
V
Q
L
P
T
Site 8
Y105
L
T
G
I
K
V
T
Y
M
E
E
E
R
N
F
Site 9
T113
M
E
E
E
R
N
F
T
T
E
Q
V
T
A
M
Site 10
T114
E
E
E
R
N
F
T
T
E
Q
V
T
A
M
L
Site 11
T118
N
F
T
T
E
Q
V
T
A
M
L
L
S
K
L
Site 12
S131
K
L
K
E
T
A
E
S
V
L
K
K
P
V
V
Site 13
S155
Y
T
D
A
E
R
R
S
V
M
D
A
T
Q
I
Site 14
T160
R
R
S
V
M
D
A
T
Q
I
A
G
L
N
C
Site 15
Y184
V
A
L
A
Y
G
I
Y
K
Q
D
L
P
A
L
Site 16
Y252
C
E
E
F
G
K
K
Y
K
L
D
I
K
S
K
Site 17
S258
K
Y
K
L
D
I
K
S
K
I
R
A
L
L
R
Site 18
S267
I
R
A
L
L
R
L
S
Q
E
C
E
K
L
K
Site 19
S278
E
K
L
K
K
L
M
S
A
N
A
S
D
L
P
Site 20
S287
N
A
S
D
L
P
L
S
I
E
C
F
M
N
D
Site 21
S323
R
V
E
P
P
L
R
S
V
L
E
Q
T
K
L
Site 22
Y336
K
L
K
K
E
D
I
Y
A
V
E
I
V
G
G
Site 23
S363
K
F
F
G
K
E
L
S
T
T
L
N
A
D
E
Site 24
T365
F
G
K
E
L
S
T
T
L
N
A
D
E
A
V
Site 25
S384
A
L
Q
C
A
I
L
S
P
A
F
K
V
R
E
Site 26
T395
K
V
R
E
F
S
I
T
D
V
V
P
Y
P
I
Site 27
Y400
S
I
T
D
V
V
P
Y
P
I
S
L
R
W
N
Site 28
S403
D
V
V
P
Y
P
I
S
L
R
W
N
S
P
A
Site 29
S408
P
I
S
L
R
W
N
S
P
A
E
E
G
S
S
Site 30
S415
S
P
A
E
E
G
S
S
D
C
E
V
F
S
K
Site 31
S429
K
N
H
A
A
P
F
S
K
V
L
T
F
Y
R
Site 32
T433
A
P
F
S
K
V
L
T
F
Y
R
K
E
P
F
Site 33
Y435
F
S
K
V
L
T
F
Y
R
K
E
P
F
T
L
Site 34
T441
F
Y
R
K
E
P
F
T
L
E
A
Y
Y
S
S
Site 35
Y445
E
P
F
T
L
E
A
Y
Y
S
S
P
Q
D
L
Site 36
Y446
P
F
T
L
E
A
Y
Y
S
S
P
Q
D
L
P
Site 37
S447
F
T
L
E
A
Y
Y
S
S
P
Q
D
L
P
Y
Site 38
S448
T
L
E
A
Y
Y
S
S
P
Q
D
L
P
Y
P
Site 39
Y454
S
S
P
Q
D
L
P
Y
P
D
P
A
I
A
Q
Site 40
T468
Q
F
S
V
Q
K
V
T
P
Q
S
D
G
S
S
Site 41
S471
V
Q
K
V
T
P
Q
S
D
G
S
S
S
K
V
Site 42
S474
V
T
P
Q
S
D
G
S
S
S
K
V
K
V
K
Site 43
S475
T
P
Q
S
D
G
S
S
S
K
V
K
V
K
V
Site 44
S476
P
Q
S
D
G
S
S
S
K
V
K
V
K
V
R
Site 45
S503
S
L
V
E
V
H
K
S
E
E
N
E
E
P
M
Site 46
T512
E
N
E
E
P
M
E
T
D
Q
N
A
K
E
E
Site 47
T538
V
E
E
Q
Q
Q
Q
T
P
A
E
N
K
A
E
Site 48
S546
P
A
E
N
K
A
E
S
E
E
M
E
T
S
Q
Site 49
T551
A
E
S
E
E
M
E
T
S
Q
A
G
S
K
D
Site 50
S552
E
S
E
E
M
E
T
S
Q
A
G
S
K
D
K
Site 51
S556
M
E
T
S
Q
A
G
S
K
D
K
K
M
D
Q
Site 52
T576
K
A
K
V
K
T
S
T
V
D
L
P
I
E
N
Site 53
Y597
D
R
E
M
L
N
L
Y
I
E
N
E
G
K
M
Site 54
Y624
A
K
N
A
V
E
E
Y
V
Y
E
M
R
D
K
Site 55
Y626
N
A
V
E
E
Y
V
Y
E
M
R
D
K
L
S
Site 56
Y636
R
D
K
L
S
G
E
Y
E
K
F
V
S
E
D
Site 57
S641
G
E
Y
E
K
F
V
S
E
D
D
R
N
S
F
Site 58
S647
V
S
E
D
D
R
N
S
F
T
L
K
L
E
D
Site 59
T655
F
T
L
K
L
E
D
T
E
N
W
L
Y
E
D
Site 60
Y660
E
D
T
E
N
W
L
Y
E
D
G
E
D
Q
P
Site 61
Y671
E
D
Q
P
K
Q
V
Y
V
D
K
L
A
E
L
Site 62
S692
I
K
I
R
F
Q
E
S
E
E
R
P
K
L
F
Site 63
Y709
L
G
K
Q
I
Q
Q
Y
M
K
I
I
S
S
F
Site 64
S715
Q
Y
M
K
I
I
S
S
F
K
N
K
E
D
Q
Site 65
Y723
F
K
N
K
E
D
Q
Y
D
H
L
D
A
A
D
Site 66
S756
L
N
L
Q
N
K
Q
S
L
T
M
D
P
V
V
Site 67
T758
L
Q
N
K
Q
S
L
T
M
D
P
V
V
K
S
Site 68
S765
T
M
D
P
V
V
K
S
K
E
I
E
A
K
I
Site 69
T776
E
A
K
I
K
E
L
T
S
T
C
S
P
I
I
Site 70
T778
K
I
K
E
L
T
S
T
C
S
P
I
I
S
K
Site 71
S780
K
E
L
T
S
T
C
S
P
I
I
S
K
P
K
Site 72
S784
S
T
C
S
P
I
I
S
K
P
K
P
K
V
E
Site 73
T824
A
A
E
Q
G
T
D
T
A
V
P
S
D
S
D
Site 74
S828
G
T
D
T
A
V
P
S
D
S
D
K
K
L
P
Site 75
S830
D
T
A
V
P
S
D
S
D
K
K
L
P
E
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation