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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MPI
Full Name:
Mannose-6-phosphate isomerase
Alias:
Phosphohexomutase;Phosphomannose isomerase
Type:
Mass (Da):
46656
Number AA:
423
UniProt ID:
P34949
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
L
S
C
A
V
Q
Q
Y
A
W
G
K
M
G
S
Site 2
S23
Y
A
W
G
K
M
G
S
N
S
E
V
A
R
L
Site 3
S25
W
G
K
M
G
S
N
S
E
V
A
R
L
L
A
Site 4
Y46
Q
I
A
E
D
K
P
Y
A
E
L
W
M
G
T
Site 5
S67
K
I
L
D
N
R
I
S
Q
K
T
L
S
Q
W
Site 6
T70
D
N
R
I
S
Q
K
T
L
S
Q
W
I
A
E
Site 7
S72
R
I
S
Q
K
T
L
S
Q
W
I
A
E
N
Q
Site 8
S81
W
I
A
E
N
Q
D
S
L
G
S
K
V
K
D
Site 9
T89
L
G
S
K
V
K
D
T
F
N
G
N
L
P
F
Site 10
S108
L
S
V
E
T
P
L
S
I
Q
A
H
P
N
K
Site 11
Y129
H
L
Q
A
P
Q
H
Y
P
D
A
N
H
K
P
Site 12
T159
R
P
V
E
E
I
V
T
F
L
K
K
V
P
E
Site 13
S184
T
H
L
K
Q
T
M
S
H
D
S
Q
A
V
A
Site 14
S187
K
Q
T
M
S
H
D
S
Q
A
V
A
S
S
L
Site 15
S192
H
D
S
Q
A
V
A
S
S
L
Q
S
C
F
S
Site 16
S193
D
S
Q
A
V
A
S
S
L
Q
S
C
F
S
H
Site 17
S199
S
S
L
Q
S
C
F
S
H
L
M
K
S
E
K
Site 18
S221
N
L
L
V
K
R
I
S
Q
Q
A
A
A
G
N
Site 19
Y245
L
L
Q
L
H
Q
Q
Y
P
G
D
I
G
C
F
Site 20
S313
P
T
L
C
E
M
L
S
Y
T
P
S
S
S
K
Site 21
Y314
T
L
C
E
M
L
S
Y
T
P
S
S
S
K
D
Site 22
T315
L
C
E
M
L
S
Y
T
P
S
S
S
K
D
R
Site 23
S317
E
M
L
S
Y
T
P
S
S
S
K
D
R
L
F
Site 24
S318
M
L
S
Y
T
P
S
S
S
K
D
R
L
F
L
Site 25
S319
L
S
Y
T
P
S
S
S
K
D
R
L
F
L
P
Site 26
T327
K
D
R
L
F
L
P
T
R
S
Q
E
D
P
Y
Site 27
S329
R
L
F
L
P
T
R
S
Q
E
D
P
Y
L
S
Site 28
Y334
T
R
S
Q
E
D
P
Y
L
S
I
Y
D
P
P
Site 29
S336
S
Q
E
D
P
Y
L
S
I
Y
D
P
P
V
P
Site 30
Y338
E
D
P
Y
L
S
I
Y
D
P
P
V
P
D
F
Site 31
T346
D
P
P
V
P
D
F
T
I
M
K
T
E
V
P
Site 32
T350
P
D
F
T
I
M
K
T
E
V
P
G
S
V
T
Site 33
S355
M
K
T
E
V
P
G
S
V
T
E
Y
K
V
L
Site 34
Y359
V
P
G
S
V
T
E
Y
K
V
L
A
L
D
S
Site 35
S366
Y
K
V
L
A
L
D
S
A
S
I
L
L
M
V
Site 36
T376
I
L
L
M
V
Q
G
T
V
I
A
S
T
P
T
Site 37
T381
Q
G
T
V
I
A
S
T
P
T
T
Q
T
P
I
Site 38
T386
A
S
T
P
T
T
Q
T
P
I
P
L
Q
R
G
Site 39
S405
I
G
A
N
E
S
V
S
L
K
L
T
E
P
K
Site 40
T409
E
S
V
S
L
K
L
T
E
P
K
D
L
L
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation