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Updated November 2019
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Protein Info
Short Name:
USP6
Full Name:
Ubiquitin carboxyl-terminal hydrolase 6
Alias:
Deubiquitinating enzyme 6; HRP1; Oncogene; Proto-oncogene TRE-2; TRE17; TRE2; Tre-2; Tre-2 oncogene; Ubiquitin specific peptidase 6; Ubiquitin thioesterase 6; Ubiquitin-specific-processing protease 6
Type:
EC 3.1.2.15; Protease
Mass (Da):
158658
Number AA:
1406
UniProt ID:
P35125
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0005097
GO:0004197
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0032313
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
D
M
V
E
N
A
D
S
L
Q
A
Q
E
R
K
Site 2
Y22
R
K
D
I
L
M
K
Y
D
K
G
H
R
A
G
Site 3
T72
K
K
I
R
R
E
M
T
R
T
S
K
W
M
E
Site 4
T74
I
R
R
E
M
T
R
T
S
K
W
M
E
M
L
Site 5
T86
E
M
L
G
E
W
E
T
Y
K
H
S
S
K
L
Site 6
Y87
M
L
G
E
W
E
T
Y
K
H
S
S
K
L
I
Site 7
Y98
S
K
L
I
D
R
V
Y
K
G
I
P
M
N
I
Site 8
Y127
K
L
K
N
P
G
R
Y
Q
I
M
K
E
R
G
Site 9
S137
M
K
E
R
G
K
R
S
S
E
H
I
H
H
I
Site 10
S138
K
E
R
G
K
R
S
S
E
H
I
H
H
I
D
Site 11
T150
H
I
D
L
D
V
R
T
T
L
R
N
H
V
F
Site 12
Y162
H
V
F
F
R
D
R
Y
G
A
K
Q
R
E
L
Site 13
Y185
E
Y
N
P
E
V
G
Y
C
R
D
L
S
H
I
Site 14
S219
L
L
A
S
E
R
H
S
L
P
G
F
H
S
P
Site 15
S225
H
S
L
P
G
F
H
S
P
N
G
G
T
V
Q
Site 16
T249
V
P
K
S
Q
P
K
T
M
W
H
Q
D
K
E
Site 17
T314
Q
Q
K
R
L
M
K
T
S
R
C
G
L
W
A
Site 18
S315
Q
K
R
L
M
K
T
S
R
C
G
L
W
A
R
Site 19
T337
T
W
A
M
N
D
D
T
V
L
K
H
L
R
A
Site 20
S345
V
L
K
H
L
R
A
S
T
K
K
L
T
R
K
Site 21
T346
L
K
H
L
R
A
S
T
K
K
L
T
R
K
Q
Site 22
S366
P
A
K
R
E
Q
G
S
L
A
P
R
P
V
P
Site 23
S375
A
P
R
P
V
P
A
S
R
G
G
K
T
L
C
Site 24
T380
P
A
S
R
G
G
K
T
L
C
K
G
Y
R
Q
Site 25
S402
Q
F
Q
R
P
I
C
S
A
S
P
P
W
A
S
Site 26
S404
Q
R
P
I
C
S
A
S
P
P
W
A
S
R
F
Site 27
S409
S
A
S
P
P
W
A
S
R
F
S
T
P
C
P
Site 28
S412
P
P
W
A
S
R
F
S
T
P
C
P
G
G
A
Site 29
T413
P
W
A
S
R
F
S
T
P
C
P
G
G
A
V
Site 30
T424
G
G
A
V
R
E
D
T
Y
P
V
G
T
Q
G
Site 31
Y425
G
A
V
R
E
D
T
Y
P
V
G
T
Q
G
V
Site 32
S445
A
Q
G
G
P
Q
G
S
W
R
F
L
E
W
K
Site 33
T459
K
S
M
P
R
L
P
T
D
L
D
I
G
G
P
Site 34
S483
S
C
W
V
R
A
I
S
Q
E
D
Q
L
A
T
Site 35
S512
M
S
W
P
E
E
M
S
F
T
A
N
S
S
K
Site 36
T514
W
P
E
E
M
S
F
T
A
N
S
S
K
I
D
Site 37
T527
I
D
R
Q
K
V
P
T
E
K
G
A
T
G
L
Site 38
S535
E
K
G
A
T
G
L
S
N
L
G
N
T
C
F
Site 39
S551
N
S
S
I
Q
C
V
S
N
T
Q
P
L
T
Q
Site 40
T553
S
I
Q
C
V
S
N
T
Q
P
L
T
Q
Y
F
Site 41
T557
V
S
N
T
Q
P
L
T
Q
Y
F
I
S
G
R
Site 42
Y559
N
T
Q
P
L
T
Q
Y
F
I
S
G
R
H
L
Site 43
S562
P
L
T
Q
Y
F
I
S
G
R
H
L
Y
E
L
Site 44
Y567
F
I
S
G
R
H
L
Y
E
L
N
R
T
N
P
Site 45
T572
H
L
Y
E
L
N
R
T
N
P
I
G
M
K
G
Site 46
Y585
K
G
H
M
A
K
C
Y
G
D
L
V
Q
E
L
Site 47
S599
L
W
S
G
T
Q
K
S
V
A
P
L
K
L
R
Site 48
T608
A
P
L
K
L
R
R
T
I
A
K
Y
A
P
K
Site 49
Y612
L
R
R
T
I
A
K
Y
A
P
K
F
D
G
F
Site 50
S624
D
G
F
Q
Q
Q
D
S
Q
E
L
L
A
F
L
Site 51
Y647
N
R
V
H
E
K
P
Y
V
E
L
K
D
S
D
Site 52
S653
P
Y
V
E
L
K
D
S
D
G
R
P
D
W
E
Site 53
S675
N
H
L
R
R
N
R
S
I
I
V
D
L
F
H
Site 54
T693
R
S
Q
V
K
C
K
T
C
G
H
I
S
V
R
Site 55
T730
V
I
K
L
D
G
T
T
P
V
R
Y
G
L
R
Site 56
Y734
D
G
T
T
P
V
R
Y
G
L
R
L
N
M
D
Site 57
Y744
R
L
N
M
D
E
K
Y
T
G
L
K
K
Q
L
Site 58
S759
R
D
L
C
G
L
N
S
E
Q
I
L
L
A
E
Site 59
S770
L
L
A
E
V
H
D
S
N
I
K
N
F
P
Q
Site 60
S800
F
E
I
P
V
P
S
S
P
I
S
A
S
S
P
Site 61
S803
P
V
P
S
S
P
I
S
A
S
S
P
T
Q
I
Site 62
S805
P
S
S
P
I
S
A
S
S
P
T
Q
I
D
F
Site 63
S806
S
S
P
I
S
A
S
S
P
T
Q
I
D
F
S
Site 64
T808
P
I
S
A
S
S
P
T
Q
I
D
F
S
S
S
Site 65
S813
S
P
T
Q
I
D
F
S
S
S
P
S
T
N
G
Site 66
S814
P
T
Q
I
D
F
S
S
S
P
S
T
N
G
M
Site 67
S815
T
Q
I
D
F
S
S
S
P
S
T
N
G
M
F
Site 68
S817
I
D
F
S
S
S
P
S
T
N
G
M
F
T
L
Site 69
T818
D
F
S
S
S
P
S
T
N
G
M
F
T
L
T
Site 70
T825
T
N
G
M
F
T
L
T
T
N
G
D
L
P
K
Site 71
T843
I
P
N
G
M
P
N
T
V
V
P
C
G
T
E
Site 72
S864
M
V
N
G
H
M
P
S
L
P
D
S
P
F
T
Site 73
S868
H
M
P
S
L
P
D
S
P
F
T
G
Y
I
I
Site 74
T884
V
H
R
K
M
M
R
T
E
L
Y
F
L
S
P
Site 75
Y887
K
M
M
R
T
E
L
Y
F
L
S
P
Q
E
N
Site 76
S890
R
T
E
L
Y
F
L
S
P
Q
E
N
R
P
S
Site 77
S897
S
P
Q
E
N
R
P
S
L
F
G
M
P
L
I
Site 78
T908
M
P
L
I
V
P
C
T
V
H
T
R
K
K
D
Site 79
Y917
H
T
R
K
K
D
L
Y
D
A
V
W
I
Q
V
Site 80
Y949
D
R
D
N
C
M
G
Y
Q
Y
P
F
T
L
R
Site 81
Y951
D
N
C
M
G
Y
Q
Y
P
F
T
L
R
V
V
Site 82
T954
M
G
Y
Q
Y
P
F
T
L
R
V
V
Q
K
D
Site 83
T1008
A
L
H
L
R
Y
Q
T
S
Q
E
R
V
V
D
Site 84
S1009
L
H
L
R
Y
Q
T
S
Q
E
R
V
V
D
K
Site 85
S1019
R
V
V
D
K
H
E
S
V
E
Q
S
R
R
A
Site 86
S1023
K
H
E
S
V
E
Q
S
R
R
A
Q
A
E
P
Site 87
S1035
A
E
P
I
N
L
D
S
C
L
R
A
F
T
S
Site 88
T1041
D
S
C
L
R
A
F
T
S
E
E
E
L
G
E
Site 89
S1042
S
C
L
R
A
F
T
S
E
E
E
L
G
E
S
Site 90
S1049
S
E
E
E
L
G
E
S
E
M
Y
Y
C
S
K
Site 91
Y1052
E
L
G
E
S
E
M
Y
Y
C
S
K
C
K
T
Site 92
Y1053
L
G
E
S
E
M
Y
Y
C
S
K
C
K
T
H
Site 93
S1107
L
R
E
S
F
D
P
S
A
F
L
V
P
R
D
Site 94
T1124
L
C
Q
H
K
P
L
T
P
Q
G
D
E
L
S
Site 95
S1131
T
P
Q
G
D
E
L
S
K
P
R
I
L
A
R
Site 96
S1147
V
K
K
V
D
A
Q
S
S
A
G
K
E
D
M
Site 97
S1148
K
K
V
D
A
Q
S
S
A
G
K
E
D
M
L
Site 98
S1157
G
K
E
D
M
L
L
S
K
S
P
S
S
L
S
Site 99
S1159
E
D
M
L
L
S
K
S
P
S
S
L
S
A
N
Site 100
S1162
L
L
S
K
S
P
S
S
L
S
A
N
I
S
S
Site 101
S1164
S
K
S
P
S
S
L
S
A
N
I
S
S
S
P
Site 102
S1168
S
S
L
S
A
N
I
S
S
S
P
K
G
S
P
Site 103
S1169
S
L
S
A
N
I
S
S
S
P
K
G
S
P
S
Site 104
S1170
L
S
A
N
I
S
S
S
P
K
G
S
P
S
S
Site 105
S1174
I
S
S
S
P
K
G
S
P
S
S
S
R
K
S
Site 106
S1176
S
S
P
K
G
S
P
S
S
S
R
K
S
G
T
Site 107
S1177
S
P
K
G
S
P
S
S
S
R
K
S
G
T
S
Site 108
S1178
P
K
G
S
P
S
S
S
R
K
S
G
T
S
C
Site 109
S1181
S
P
S
S
S
R
K
S
G
T
S
C
P
S
S
Site 110
T1183
S
S
S
R
K
S
G
T
S
C
P
S
S
K
N
Site 111
S1184
S
S
R
K
S
G
T
S
C
P
S
S
K
N
S
Site 112
S1187
K
S
G
T
S
C
P
S
S
K
N
S
S
P
N
Site 113
S1188
S
G
T
S
C
P
S
S
K
N
S
S
P
N
S
Site 114
S1191
S
C
P
S
S
K
N
S
S
P
N
S
S
P
R
Site 115
S1192
C
P
S
S
K
N
S
S
P
N
S
S
P
R
T
Site 116
S1195
S
K
N
S
S
P
N
S
S
P
R
T
L
G
R
Site 117
S1196
K
N
S
S
P
N
S
S
P
R
T
L
G
R
S
Site 118
T1199
S
P
N
S
S
P
R
T
L
G
R
S
K
G
R
Site 119
S1203
S
P
R
T
L
G
R
S
K
G
R
L
R
L
P
Site 120
S1214
L
R
L
P
Q
I
G
S
K
N
K
P
S
S
S
Site 121
S1219
I
G
S
K
N
K
P
S
S
S
K
K
N
L
D
Site 122
S1220
G
S
K
N
K
P
S
S
S
K
K
N
L
D
A
Site 123
S1221
S
K
N
K
P
S
S
S
K
K
N
L
D
A
S
Site 124
S1244
C
E
L
A
D
A
L
S
R
G
H
M
R
G
G
Site 125
S1252
R
G
H
M
R
G
G
S
Q
P
E
L
V
T
P
Site 126
T1258
G
S
Q
P
E
L
V
T
P
Q
D
H
E
V
A
Site 127
Y1272
A
L
A
N
G
F
L
Y
E
H
E
A
C
G
N
Site 128
Y1285
G
N
G
C
G
D
G
Y
S
N
G
Q
L
G
N
Site 129
S1294
N
G
Q
L
G
N
H
S
E
E
D
S
T
D
D
Site 130
S1298
G
N
H
S
E
E
D
S
T
D
D
Q
R
E
D
Site 131
T1299
N
H
S
E
E
D
S
T
D
D
Q
R
E
D
T
Site 132
T1306
T
D
D
Q
R
E
D
T
H
I
K
P
I
Y
N
Site 133
Y1329
G
I
L
S
G
G
H
Y
I
T
Y
A
K
N
P
Site 134
T1331
L
S
G
G
H
Y
I
T
Y
A
K
N
P
N
C
Site 135
Y1332
S
G
G
H
Y
I
T
Y
A
K
N
P
N
C
K
Site 136
T1358
L
H
P
D
E
I
D
T
D
S
A
Y
I
L
F
Site 137
S1360
P
D
E
I
D
T
D
S
A
Y
I
L
F
Y
E
Site 138
Y1362
E
I
D
T
D
S
A
Y
I
L
F
Y
E
Q
Q
Site 139
Y1366
D
S
A
Y
I
L
F
Y
E
Q
Q
G
I
D
Y
Site 140
Y1373
Y
E
Q
Q
G
I
D
Y
A
Q
F
L
P
K
I
Site 141
T1388
D
G
K
K
M
A
D
T
S
S
T
D
E
D
S
Site 142
S1389
G
K
K
M
A
D
T
S
S
T
D
E
D
S
E
Site 143
S1390
K
K
M
A
D
T
S
S
T
D
E
D
S
E
S
Site 144
T1391
K
M
A
D
T
S
S
T
D
E
D
S
E
S
D
Site 145
S1395
T
S
S
T
D
E
D
S
E
S
D
Y
E
K
Y
Site 146
S1397
S
T
D
E
D
S
E
S
D
Y
E
K
Y
S
M
Site 147
Y1399
D
E
D
S
E
S
D
Y
E
K
Y
S
M
L
Q
Site 148
Y1402
S
E
S
D
Y
E
K
Y
S
M
L
Q
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation