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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADRA1A
Full Name:
Alpha-1A adrenergic receptor
Alias:
ADA1A; ADRA1C; Adrenergic receptor, alpha-1A; Alpha 1A- adrenoreceptor; Alpha 1A-adrenoceptor; Alpha adrenergic receptor 1c; Alpha-1C adrenergic receptor
Type:
Receptor, G protein-coupled
Mass (Da):
51487
Number AA:
466
UniProt ID:
P35348
International Prot ID:
IPI00430196
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0004937
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0006915
GO:0007267
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
V
F
L
S
G
N
A
S
D
S
S
N
C
T
Q
Site 2
S11
L
S
G
N
A
S
D
S
S
N
C
T
Q
P
P
Site 3
S12
S
G
N
A
S
D
S
S
N
C
T
Q
P
P
A
Site 4
T15
A
S
D
S
S
N
C
T
Q
P
P
A
P
V
N
Site 5
S129
I
D
R
Y
I
G
V
S
Y
P
L
R
Y
P
T
Site 6
Y130
D
R
Y
I
G
V
S
Y
P
L
R
Y
P
T
I
Site 7
Y134
G
V
S
Y
P
L
R
Y
P
T
I
V
T
Q
R
Site 8
T136
S
Y
P
L
R
Y
P
T
I
V
T
Q
R
R
G
Site 9
T139
L
R
Y
P
T
I
V
T
Q
R
R
G
L
M
A
Site 10
T174
Q
P
A
P
E
D
E
T
I
C
Q
I
N
E
E
Site 11
S215
Y
V
V
A
K
R
E
S
R
G
L
K
S
G
L
Site 12
S220
R
E
S
R
G
L
K
S
G
L
K
T
D
K
S
Site 13
T224
G
L
K
S
G
L
K
T
D
K
S
D
S
E
Q
Site 14
S227
S
G
L
K
T
D
K
S
D
S
E
Q
V
T
L
Site 15
S229
L
K
T
D
K
S
D
S
E
Q
V
T
L
R
I
Site 16
T233
K
S
D
S
E
Q
V
T
L
R
I
H
R
K
N
Site 17
S246
K
N
A
P
A
G
G
S
G
M
A
S
A
K
T
Site 18
S250
A
G
G
S
G
M
A
S
A
K
T
K
T
H
F
Site 19
T253
S
G
M
A
S
A
K
T
K
T
H
F
S
V
R
Site 20
S258
A
K
T
K
T
H
F
S
V
R
L
L
K
F
S
Site 21
S265
S
V
R
L
L
K
F
S
R
E
K
K
A
A
K
Site 22
T273
R
E
K
K
A
A
K
T
L
G
I
V
V
G
C
Site 23
S304
F
F
P
D
F
K
P
S
E
T
V
F
K
I
V
Site 24
T306
P
D
F
K
P
S
E
T
V
F
K
I
V
F
W
Site 25
S329
N
P
I
I
Y
P
C
S
S
Q
E
F
K
K
A
Site 26
S330
P
I
I
Y
P
C
S
S
Q
E
F
K
K
A
F
Site 27
S351
Q
C
L
C
R
K
Q
S
S
K
H
A
L
G
Y
Site 28
Y358
S
S
K
H
A
L
G
Y
T
L
H
P
P
S
Q
Site 29
T359
S
K
H
A
L
G
Y
T
L
H
P
P
S
Q
A
Site 30
S364
G
Y
T
L
H
P
P
S
Q
A
V
E
G
Q
H
Site 31
S381
M
V
R
I
P
V
G
S
R
E
T
F
Y
R
I
Site 32
T384
I
P
V
G
S
R
E
T
F
Y
R
I
S
K
T
Site 33
Y386
V
G
S
R
E
T
F
Y
R
I
S
K
T
D
G
Site 34
S389
R
E
T
F
Y
R
I
S
K
T
D
G
V
C
E
Site 35
S402
C
E
W
K
F
F
S
S
M
P
R
G
S
A
R
Site 36
S407
F
S
S
M
P
R
G
S
A
R
I
T
V
S
K
Site 37
T411
P
R
G
S
A
R
I
T
V
S
K
D
Q
S
S
Site 38
S413
G
S
A
R
I
T
V
S
K
D
Q
S
S
C
T
Site 39
S417
I
T
V
S
K
D
Q
S
S
C
T
T
A
R
V
Site 40
T420
S
K
D
Q
S
S
C
T
T
A
R
V
R
S
K
Site 41
T421
K
D
Q
S
S
C
T
T
A
R
V
R
S
K
S
Site 42
T440
C
C
C
V
G
P
S
T
P
S
L
D
K
N
H
Site 43
S442
C
V
G
P
S
T
P
S
L
D
K
N
H
Q
V
Site 44
T456
V
P
T
I
K
V
H
T
I
S
L
S
E
N
G
Site 45
S458
T
I
K
V
H
T
I
S
L
S
E
N
G
E
E
Site 46
S460
K
V
H
T
I
S
L
S
E
N
G
E
E
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation