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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
COX-2
Full Name:
Prostaglandin G/H synthase 2
Alias:
COX2; Cyclooxygenase-2; PGH synthase 2; PGH2; PGHS-2; PHS II; Prostaglandin G/H synthase 2; Prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2
Type:
Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.14.99.1
Mass (Da):
68996
Number AA:
604
UniProt ID:
P35354
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005788
GO:0019898
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0020037
GO:0016702
GO:0004601
PhosphoSite+
KinaseNET
Biological Process:
GO:0006928
GO:0019371
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y40
M
S
V
G
F
D
Q
Y
K
C
D
C
T
R
T
Site 2
S55
G
F
Y
G
E
N
C
S
T
P
E
F
L
T
R
Site 3
T56
F
Y
G
E
N
C
S
T
P
E
F
L
T
R
I
Site 4
T73
F
L
K
P
T
P
N
T
V
H
Y
I
L
T
H
Site 5
Y101
L
R
N
A
I
M
S
Y
V
L
T
S
R
S
H
Site 6
S107
S
Y
V
L
T
S
R
S
H
L
I
D
S
P
P
Site 7
S112
S
R
S
H
L
I
D
S
P
P
T
Y
N
A
D
Site 8
Y116
L
I
D
S
P
P
T
Y
N
A
D
Y
G
Y
K
Site 9
Y120
P
P
T
Y
N
A
D
Y
G
Y
K
S
W
E
A
Site 10
Y122
T
Y
N
A
D
Y
G
Y
K
S
W
E
A
F
S
Site 11
Y133
E
A
F
S
N
L
S
Y
Y
T
R
A
L
P
P
Site 12
Y134
A
F
S
N
L
S
Y
Y
T
R
A
L
P
P
V
Site 13
T147
P
V
P
D
D
C
P
T
P
L
G
V
K
G
K
Site 14
S160
G
K
K
Q
L
P
D
S
N
E
I
V
E
K
L
Site 15
T198
F
T
H
Q
F
F
K
T
D
H
K
R
G
P
A
Site 16
T207
H
K
R
G
P
A
F
T
N
G
L
G
H
G
V
Site 17
Y240
F
K
D
G
K
M
K
Y
Q
I
I
D
G
E
M
Site 18
Y248
Q
I
I
D
G
E
M
Y
P
P
T
V
K
D
T
Site 19
T251
D
G
E
M
Y
P
P
T
V
K
D
T
Q
A
E
Site 20
Y261
D
T
Q
A
E
M
I
Y
P
P
Q
V
P
E
H
Site 21
Y359
L
F
N
K
Q
F
Q
Y
Q
N
R
I
A
A
E
Site 22
Y371
A
A
E
F
N
T
L
Y
H
W
H
P
L
L
P
Site 23
Y390
I
H
D
Q
K
Y
N
Y
Q
Q
F
I
Y
N
N
Site 24
Y395
Y
N
Y
Q
Q
F
I
Y
N
N
S
I
L
L
E
Site 25
S434
P
P
A
V
Q
K
V
S
Q
A
S
I
D
Q
S
Site 26
S437
V
Q
K
V
S
Q
A
S
I
D
Q
S
R
Q
M
Site 27
S441
S
Q
A
S
I
D
Q
S
R
Q
M
K
Y
Q
S
Site 28
Y446
D
Q
S
R
Q
M
K
Y
Q
S
F
N
E
Y
R
Site 29
S448
S
R
Q
M
K
Y
Q
S
F
N
E
Y
R
K
R
Site 30
Y452
K
Y
Q
S
F
N
E
Y
R
K
R
F
M
L
K
Site 31
Y461
K
R
F
M
L
K
P
Y
E
S
F
E
E
L
T
Site 32
S463
F
M
L
K
P
Y
E
S
F
E
E
L
T
G
E
Site 33
S474
L
T
G
E
K
E
M
S
A
E
L
E
A
L
Y
Site 34
Y530
N
V
I
C
S
P
A
Y
W
K
P
S
T
F
G
Site 35
S534
S
P
A
Y
W
K
P
S
T
F
G
G
E
V
G
Site 36
T535
P
A
Y
W
K
P
S
T
F
G
G
E
V
G
F
Site 37
S565
V
K
G
C
P
F
T
S
F
S
V
P
D
P
E
Site 38
T576
P
D
P
E
L
I
K
T
V
T
I
N
A
S
S
Site 39
T578
P
E
L
I
K
T
V
T
I
N
A
S
S
S
R
Site 40
S582
K
T
V
T
I
N
A
S
S
S
R
S
G
L
D
Site 41
S583
T
V
T
I
N
A
S
S
S
R
S
G
L
D
D
Site 42
S584
V
T
I
N
A
S
S
S
R
S
G
L
D
D
I
Site 43
S586
I
N
A
S
S
S
R
S
G
L
D
D
I
N
P
Site 44
S601
T
V
L
L
K
E
R
S
T
E
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation