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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THBS4
Full Name:
Thrombospondin-4
Alias:
Type:
Mass (Da):
105869
Number AA:
961
UniProt ID:
P35443
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
Q
V
F
D
L
L
P
S
S
S
Q
R
L
N
P
Site 2
S37
V
F
D
L
L
P
S
S
S
Q
R
L
N
P
G
Site 3
S38
F
D
L
L
P
S
S
S
Q
R
L
N
P
G
A
Site 4
T63
N
D
L
Y
V
I
S
T
F
K
L
Q
T
K
S
Site 5
Y78
S
A
T
I
F
G
L
Y
S
S
T
D
N
S
K
Site 6
S79
A
T
I
F
G
L
Y
S
S
T
D
N
S
K
Y
Site 7
S80
T
I
F
G
L
Y
S
S
T
D
N
S
K
Y
F
Site 8
S84
L
Y
S
S
T
D
N
S
K
Y
F
E
F
T
V
Site 9
Y86
S
S
T
D
N
S
K
Y
F
E
F
T
V
M
G
Site 10
T90
N
S
K
Y
F
E
F
T
V
M
G
R
L
N
K
Site 11
Y102
L
N
K
A
I
L
R
Y
L
K
N
D
G
K
V
Site 12
S132
H
R
I
L
L
R
L
S
N
L
Q
R
G
A
G
Site 13
S140
N
L
Q
R
G
A
G
S
L
E
L
Y
L
D
C
Site 14
S152
L
D
C
I
Q
V
D
S
V
H
N
L
P
R
A
Site 15
S164
P
R
A
F
A
G
P
S
Q
K
P
E
T
I
E
Site 16
T169
G
P
S
Q
K
P
E
T
I
E
L
R
T
F
Q
Site 17
T174
P
E
T
I
E
L
R
T
F
Q
R
K
P
Q
D
Site 18
S249
R
Q
Q
V
K
E
T
S
F
L
R
N
T
I
A
Site 19
T254
E
T
S
F
L
R
N
T
I
A
E
C
Q
A
C
Site 20
S268
C
G
P
L
K
F
Q
S
P
T
P
S
T
V
V
Site 21
T270
P
L
K
F
Q
S
P
T
P
S
T
V
V
P
P
Site 22
S272
K
F
Q
S
P
T
P
S
T
V
V
P
P
A
P
Site 23
T273
F
Q
S
P
T
P
S
T
V
V
P
P
A
P
P
Site 24
T284
P
A
P
P
A
P
P
T
R
P
P
R
R
C
D
Site 25
S292
R
P
P
R
R
C
D
S
N
P
C
F
R
G
V
Site 26
S304
R
G
V
Q
C
T
D
S
R
D
G
F
Q
C
G
Site 27
Y317
C
G
P
C
P
E
G
Y
T
G
N
G
I
T
C
Site 28
Y332
I
D
V
D
E
C
K
Y
H
P
C
Y
P
G
V
Site 29
S368
M
V
Q
G
V
G
I
S
F
A
K
S
N
K
Q
Site 30
S372
V
G
I
S
F
A
K
S
N
K
Q
V
C
T
D
Site 31
Y410
C
G
P
C
K
P
G
Y
T
G
D
Q
I
R
G
Site 32
Y459
V
G
W
A
G
D
G
Y
I
C
G
K
D
V
D
Site 33
S469
G
K
D
V
D
I
D
S
Y
P
D
E
E
L
P
Site 34
Y470
K
D
V
D
I
D
S
Y
P
D
E
E
L
P
C
Site 35
S478
P
D
E
E
L
P
C
S
A
R
N
C
K
K
D
Site 36
Y489
C
K
K
D
N
C
K
Y
V
P
N
S
G
Q
E
Site 37
S534
H
N
V
D
Q
R
N
S
D
K
D
I
F
G
D
Site 38
T557
L
N
N
D
Q
K
D
T
D
G
D
G
R
G
D
Site 39
S604
G
V
G
D
A
C
D
S
C
P
D
V
S
N
P
Site 40
S609
C
D
S
C
P
D
V
S
N
P
N
Q
S
D
V
Site 41
S624
D
N
D
L
V
G
D
S
C
D
T
N
Q
D
S
Site 42
T627
L
V
G
D
S
C
D
T
N
Q
D
S
D
G
D
Site 43
S631
S
C
D
T
N
Q
D
S
D
G
D
G
H
Q
D
Site 44
S639
D
G
D
G
H
Q
D
S
T
D
N
C
P
T
V
Site 45
T640
G
D
G
H
Q
D
S
T
D
N
C
P
T
V
I
Site 46
T645
D
S
T
D
N
C
P
T
V
I
N
S
A
Q
L
Site 47
S694
P
N
P
A
Q
E
D
S
N
S
D
G
V
G
D
Site 48
S696
P
A
Q
E
D
S
N
S
D
G
V
G
D
I
C
Site 49
S705
G
V
G
D
I
C
E
S
D
F
D
Q
D
Q
V
Site 50
T728
E
N
A
E
V
T
L
T
D
F
R
A
Y
Q
T
Site 51
T762
Q
G
M
E
I
V
Q
T
M
N
S
D
P
G
L
Site 52
Y795
N
T
Q
T
D
D
D
Y
A
G
F
I
F
G
Y
Site 53
Y802
Y
A
G
F
I
F
G
Y
Q
D
S
S
S
F
Y
Site 54
Y809
Y
Q
D
S
S
S
F
Y
V
V
M
W
K
Q
T
Site 55
T824
E
Q
T
Y
W
Q
A
T
P
F
R
A
V
A
E
Site 56
S841
I
Q
L
K
A
V
K
S
K
T
G
P
G
E
H
Site 57
T843
L
K
A
V
K
S
K
T
G
P
G
E
H
L
R
Site 58
S852
P
G
E
H
L
R
N
S
L
W
H
T
G
D
T
Site 59
T856
L
R
N
S
L
W
H
T
G
D
T
S
D
Q
V
Site 60
Y881
G
W
K
D
K
V
S
Y
R
W
F
L
Q
H
R
Site 61
Y893
Q
H
R
P
Q
V
G
Y
I
R
V
R
F
Y
E
Site 62
Y899
G
Y
I
R
V
R
F
Y
E
G
S
E
L
V
A
Site 63
S902
R
V
R
F
Y
E
G
S
E
L
V
A
D
S
G
Site 64
T914
D
S
G
V
T
I
D
T
T
M
R
G
G
R
L
Site 65
T915
S
G
V
T
I
D
T
T
M
R
G
G
R
L
G
Site 66
Y938
I
I
W
S
N
L
K
Y
R
C
N
D
T
I
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation