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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IDUA
Full Name:
Alpha-L-iduronidase
Alias:
Type:
Mass (Da):
72670
Number AA:
653
UniProt ID:
P35475
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S49
P
L
R
R
F
W
R
S
T
G
F
C
P
P
L
Site 2
T50
L
R
R
F
W
R
S
T
G
F
C
P
P
L
P
Site 3
S59
F
C
P
P
L
P
H
S
Q
A
D
Q
Y
V
L
Site 4
Y64
P
H
S
Q
A
D
Q
Y
V
L
S
W
D
Q
Q
Site 5
S67
Q
A
D
Q
Y
V
L
S
W
D
Q
Q
L
N
L
Site 6
Y76
D
Q
Q
L
N
L
A
Y
V
G
A
V
P
H
R
Site 7
T98
H
W
L
L
E
L
V
T
T
R
G
S
T
G
R
Site 8
T99
W
L
L
E
L
V
T
T
R
G
S
T
G
R
G
Site 9
S102
E
L
V
T
T
R
G
S
T
G
R
G
L
S
Y
Site 10
T103
L
V
T
T
R
G
S
T
G
R
G
L
S
Y
N
Site 11
S108
G
S
T
G
R
G
L
S
Y
N
F
T
H
L
D
Site 12
Y109
S
T
G
R
G
L
S
Y
N
F
T
H
L
D
G
Site 13
T112
R
G
L
S
Y
N
F
T
H
L
D
G
Y
L
D
Site 14
Y117
N
F
T
H
L
D
G
Y
L
D
L
L
R
E
N
Site 15
S135
P
G
F
E
L
M
G
S
A
S
G
H
F
T
D
Site 16
S137
F
E
L
M
G
S
A
S
G
H
F
T
D
F
E
Site 17
T141
G
S
A
S
G
H
F
T
D
F
E
D
K
Q
Q
Site 18
S158
E
W
K
D
L
V
S
S
L
A
R
R
Y
I
G
Site 19
Y163
V
S
S
L
A
R
R
Y
I
G
R
Y
G
L
A
Site 20
Y167
A
R
R
Y
I
G
R
Y
G
L
A
H
V
S
K
Site 21
Y201
T
M
Q
G
F
L
N
Y
Y
D
A
C
S
E
G
Site 22
Y202
M
Q
G
F
L
N
Y
Y
D
A
C
S
E
G
L
Site 23
S213
S
E
G
L
R
A
A
S
P
A
L
R
L
G
G
Site 24
S224
R
L
G
G
P
G
D
S
F
H
T
P
P
R
S
Site 25
T227
G
P
G
D
S
F
H
T
P
P
R
S
P
L
S
Site 26
S231
S
F
H
T
P
P
R
S
P
L
S
W
G
L
L
Site 27
S234
T
P
P
R
S
P
L
S
W
G
L
L
R
H
C
Site 28
T245
L
R
H
C
H
D
G
T
N
F
F
T
G
E
A
Site 29
Y258
E
A
G
V
R
L
D
Y
I
S
L
H
R
K
G
Site 30
S260
G
V
R
L
D
Y
I
S
L
H
R
K
G
A
R
Site 31
S268
L
H
R
K
G
A
R
S
S
I
S
I
L
E
Q
Site 32
S269
H
R
K
G
A
R
S
S
I
S
I
L
E
Q
E
Site 33
T293
L
F
P
K
F
A
D
T
P
I
Y
N
D
E
A
Site 34
Y296
K
F
A
D
T
P
I
Y
N
D
E
A
D
P
L
Site 35
T317
Q
P
W
R
A
D
V
T
Y
A
A
M
V
V
K
Site 36
Y343
N
T
T
S
A
F
P
Y
A
L
L
S
N
D
N
Site 37
T364
P
H
P
F
A
Q
R
T
L
T
A
R
F
Q
V
Site 38
T366
P
F
A
Q
R
T
L
T
A
R
F
Q
V
N
N
Site 39
S406
E
Q
L
W
A
E
V
S
Q
A
G
T
V
L
D
Site 40
T410
A
E
V
S
Q
A
G
T
V
L
D
S
N
H
T
Site 41
S423
H
T
V
G
V
L
A
S
A
H
R
P
Q
G
P
Site 42
S443
A
A
V
L
I
Y
A
S
D
D
T
R
A
H
P
Site 43
T446
L
I
Y
A
S
D
D
T
R
A
H
P
N
R
S
Site 44
S453
T
R
A
H
P
N
R
S
V
A
V
T
L
R
L
Site 45
T457
P
N
R
S
V
A
V
T
L
R
L
R
G
V
P
Site 46
Y471
P
P
G
P
G
L
V
Y
V
T
R
Y
L
D
N
Site 47
S482
Y
L
D
N
G
L
C
S
P
D
G
E
W
R
R
Site 48
T497
L
G
R
P
V
F
P
T
A
E
Q
F
R
R
M
Site 49
S569
G
Q
L
V
L
V
W
S
D
E
H
V
G
S
K
Site 50
Y581
G
S
K
C
L
W
T
Y
E
I
Q
F
S
Q
D
Site 51
Y592
F
S
Q
D
G
K
A
Y
T
P
V
S
R
K
P
Site 52
T593
S
Q
D
G
K
A
Y
T
P
V
S
R
K
P
S
Site 53
S596
G
K
A
Y
T
P
V
S
R
K
P
S
T
F
N
Site 54
T601
P
V
S
R
K
P
S
T
F
N
L
F
V
F
S
Site 55
S615
S
P
D
T
G
A
V
S
G
S
Y
R
V
R
A
Site 56
S617
D
T
G
A
V
S
G
S
Y
R
V
R
A
L
D
Site 57
Y618
T
G
A
V
S
G
S
Y
R
V
R
A
L
D
Y
Site 58
Y625
Y
R
V
R
A
L
D
Y
W
A
R
P
G
P
F
Site 59
S633
W
A
R
P
G
P
F
S
D
P
V
P
Y
L
E
Site 60
Y638
P
F
S
D
P
V
P
Y
L
E
V
P
V
P
R
Site 61
S649
P
V
P
R
G
P
P
S
P
G
N
P
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation