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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCN4A
Full Name:
Sodium channel protein type 4 subunit alpha
Alias:
SkM1;Sodium channel protein skeletal muscle subunit alpha;Sodium channel protein type IV subunit alpha;Voltage-gated sodium channel subunit alpha Nav1.4
Type:
Mass (Da):
208061
Number AA:
1836
UniProt ID:
P35499
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
P
E
C
L
R
P
F
T
R
E
S
L
A
A
I
Site 2
S24
L
R
P
F
T
R
E
S
L
A
A
I
E
Q
R
Site 3
S56
E
P
E
R
K
P
R
S
D
L
E
A
G
K
N
Site 4
Y68
G
K
N
L
P
M
I
Y
G
D
P
P
P
E
V
Site 5
Y86
P
L
E
D
L
D
P
Y
Y
S
N
K
K
T
F
Site 6
Y87
L
E
D
L
D
P
Y
Y
S
N
K
K
T
F
I
Site 7
S88
E
D
L
D
P
Y
Y
S
N
K
K
T
F
I
V
Site 8
T92
P
Y
Y
S
N
K
K
T
F
I
V
L
N
K
G
Site 9
Y162
P
W
S
K
N
V
E
Y
T
F
T
G
I
Y
T
Site 10
T163
W
S
K
N
V
E
Y
T
F
T
G
I
Y
T
F
Site 11
T165
K
N
V
E
Y
T
F
T
G
I
Y
T
F
E
S
Site 12
T187
G
F
C
V
D
D
F
T
F
L
R
D
P
W
N
Site 13
T231
L
R
A
L
K
T
I
T
V
I
P
G
L
K
T
Site 14
Y341
D
T
F
D
W
D
A
Y
I
S
D
E
G
N
F
Site 15
Y349
I
S
D
E
G
N
F
Y
F
L
E
G
S
N
D
Site 16
S363
D
A
L
L
C
G
N
S
S
D
A
G
H
C
P
Site 17
S364
A
L
L
C
G
N
S
S
D
A
G
H
C
P
E
Site 18
Y373
A
G
H
C
P
E
G
Y
E
C
I
K
T
G
R
Site 19
T378
E
G
Y
E
C
I
K
T
G
R
N
P
N
Y
G
Site 20
Y384
K
T
G
R
N
P
N
Y
G
Y
T
S
Y
D
T
Site 21
Y386
G
R
N
P
N
Y
G
Y
T
S
Y
D
T
F
S
Site 22
Y389
P
N
Y
G
Y
T
S
Y
D
T
F
S
W
A
F
Site 23
T404
L
A
L
F
R
L
M
T
Q
D
Y
W
E
N
L
Site 24
Y407
F
R
L
M
T
Q
D
Y
W
E
N
L
F
Q
L
Site 25
S435
V
V
I
I
F
L
G
S
F
Y
L
I
N
L
I
Site 26
T457
Y
A
E
Q
N
E
A
T
L
A
E
D
K
E
K
Site 27
S509
H
G
K
D
C
N
G
S
L
D
T
S
Q
G
E
Site 28
S513
C
N
G
S
L
D
T
S
Q
G
E
K
G
A
P
Site 29
S523
E
K
G
A
P
R
Q
S
G
S
G
D
S
G
I
Site 30
S525
G
A
P
R
Q
S
G
S
G
D
S
G
I
S
D
Site 31
Y635
K
L
I
A
M
D
P
Y
E
Y
F
Q
Q
G
W
Site 32
S809
L
S
S
F
S
A
D
S
L
A
A
S
D
E
D
Site 33
S813
S
A
D
S
L
A
A
S
D
E
D
G
E
M
N
Site 34
T873
E
A
G
E
A
G
E
T
A
P
E
D
E
K
K
Site 35
S905
G
L
A
D
G
P
P
S
S
L
E
L
D
H
L
Site 36
S906
L
A
D
G
P
P
S
S
L
E
L
D
H
L
N
Site 37
T943
P
T
E
E
E
T
D
T
F
S
E
P
E
D
S
Site 38
S945
E
E
E
T
D
T
F
S
E
P
E
D
S
K
K
Site 39
S950
T
F
S
E
P
E
D
S
K
K
P
P
Q
P
L
Site 40
Y958
K
K
P
P
Q
P
L
Y
D
G
N
S
S
V
C
Site 41
S962
Q
P
L
Y
D
G
N
S
S
V
C
S
T
A
D
Site 42
S963
P
L
Y
D
G
N
S
S
V
C
S
T
A
D
Y
Site 43
S966
D
G
N
S
S
V
C
S
T
A
D
Y
K
P
P
Site 44
T967
G
N
S
S
V
C
S
T
A
D
Y
K
P
P
E
Site 45
Y970
S
V
C
S
T
A
D
Y
K
P
P
E
E
D
P
Site 46
Y1006
V
Q
R
W
P
C
L
Y
V
D
I
S
Q
G
R
Site 47
T1063
E
Q
R
R
V
I
R
T
I
L
E
Y
A
D
K
Site 48
S1127
S
E
L
G
P
I
K
S
L
R
T
L
R
A
L
Site 49
T1130
G
P
I
K
S
L
R
T
L
R
A
L
R
P
L
Site 50
S1141
L
R
P
L
R
A
L
S
R
F
E
G
M
R
V
Site 51
S1201
T
S
E
R
F
D
I
S
E
V
N
N
K
S
E
Site 52
S1207
I
S
E
V
N
N
K
S
E
C
E
S
L
M
H
Site 53
S1211
N
N
K
S
E
C
E
S
L
M
H
T
G
Q
V
Site 54
T1215
E
C
E
S
L
M
H
T
G
Q
V
R
W
L
N
Site 55
Y1227
W
L
N
V
K
V
N
Y
D
N
V
G
L
G
Y
Site 56
Y1251
K
G
W
M
D
I
M
Y
A
A
V
D
S
R
E
Site 57
S1256
I
M
Y
A
A
V
D
S
R
E
K
E
E
Q
P
Site 58
Y1265
E
K
E
E
Q
P
Q
Y
E
V
N
L
Y
M
Y
Site 59
T1313
G
G
K
D
I
F
M
T
E
E
Q
K
K
Y
Y
Site 60
Y1319
M
T
E
E
Q
K
K
Y
Y
N
A
M
K
K
L
Site 61
Y1347
N
K
I
Q
G
M
V
Y
D
L
V
T
K
Q
A
Site 62
S1378
M
V
E
T
D
D
Q
S
Q
L
K
V
D
I
L
Site 63
Y1386
Q
L
K
V
D
I
L
Y
N
I
N
M
I
F
I
Site 64
T1397
M
I
F
I
I
I
F
T
G
E
C
V
L
K
M
Site 65
Y1410
K
M
L
A
L
R
Q
Y
Y
F
T
V
G
W
N
Site 66
Y1440
L
S
D
L
I
Q
K
Y
F
V
S
P
T
L
F
Site 67
S1443
L
I
Q
K
Y
F
V
S
P
T
L
F
R
V
I
Site 68
Y1506
F
G
M
S
N
F
A
Y
V
K
K
E
S
G
I
Site 69
T1562
P
N
L
E
N
P
G
T
S
V
K
G
D
C
G
Site 70
S1563
N
L
E
N
P
G
T
S
V
K
G
D
C
G
N
Site 71
Y1621
E
D
D
F
E
M
F
Y
E
T
W
E
K
F
D
Site 72
T1632
E
K
F
D
P
D
A
T
Q
F
I
A
Y
S
R
Site 73
T1646
R
L
S
D
F
V
D
T
L
Q
E
P
L
R
I
Site 74
S1711
K
F
M
A
A
N
P
S
K
V
S
Y
E
P
I
Site 75
Y1715
A
N
P
S
K
V
S
Y
E
P
I
T
T
T
L
Site 76
T1720
V
S
Y
E
P
I
T
T
T
L
K
R
K
H
E
Site 77
T1721
S
Y
E
P
I
T
T
T
L
K
R
K
H
E
E
Site 78
Y1738
A
I
K
I
Q
R
A
Y
R
R
H
L
L
Q
R
Site 79
S1746
R
R
H
L
L
Q
R
S
M
K
Q
A
S
Y
M
Site 80
Y1752
R
S
M
K
Q
A
S
Y
M
Y
R
H
S
H
D
Site 81
Y1754
M
K
Q
A
S
Y
M
Y
R
H
S
H
D
G
S
Site 82
S1757
A
S
Y
M
Y
R
H
S
H
D
G
S
G
D
D
Site 83
S1761
Y
R
H
S
H
D
G
S
G
D
D
A
P
E
K
Site 84
S1787
Y
G
H
E
N
G
N
S
S
S
P
S
P
E
E
Site 85
S1788
G
H
E
N
G
N
S
S
S
P
S
P
E
E
K
Site 86
S1789
H
E
N
G
N
S
S
S
P
S
P
E
E
K
G
Site 87
S1791
N
G
N
S
S
S
P
S
P
E
E
K
G
E
A
Site 88
S1811
T
M
G
L
M
P
I
S
P
S
D
T
A
W
P
Site 89
S1813
G
L
M
P
I
S
P
S
D
T
A
W
P
P
A
Site 90
T1815
M
P
I
S
P
S
D
T
A
W
P
P
A
P
P
Site 91
T1826
P
A
P
P
P
G
Q
T
V
R
P
G
V
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation