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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CBS
Full Name:
Cystathionine beta-synthase
Alias:
Beta-thionase;Serine sulfhydrase
Type:
Mass (Da):
Number AA:
UniProt ID:
P35520
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0004122
GO:0020037
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0019448
GO:0006565
GO:0006535
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
P
S
E
T
P
Q
A
E
V
G
P
Site 2
T13
P
Q
A
E
V
G
P
T
G
C
P
H
R
S
G
Site 3
S19
P
T
G
C
P
H
R
S
G
P
H
S
A
K
G
Site 4
S23
P
H
R
S
G
P
H
S
A
K
G
S
L
E
K
Site 5
S27
G
P
H
S
A
K
G
S
L
E
K
G
S
P
E
Site 6
S32
K
G
S
L
E
K
G
S
P
E
D
K
E
A
K
Site 7
T53
P
D
A
P
S
R
C
T
W
Q
L
G
R
P
A
Site 8
S61
W
Q
L
G
R
P
A
S
E
S
P
H
H
H
T
Site 9
S63
L
G
R
P
A
S
E
S
P
H
H
H
T
A
P
Site 10
S73
H
H
T
A
P
A
K
S
P
K
I
L
P
D
I
Site 11
T87
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
Site 12
S117
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
Site 13
S123
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
Site 14
T135
E
D
A
E
R
D
G
T
L
K
P
G
D
T
I
Site 15
T141
G
T
L
K
P
G
D
T
I
I
E
P
T
S
G
Site 16
S147
D
T
I
I
E
P
T
S
G
N
T
G
I
G
L
Site 17
S175
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
Site 18
T191
L
G
A
E
I
V
R
T
P
T
N
A
R
F
D
Site 19
T193
A
E
I
V
R
T
P
T
N
A
R
F
D
S
P
Site 20
S199
P
T
N
A
R
F
D
S
P
E
S
H
V
G
V
Site 21
S202
A
R
F
D
S
P
E
S
H
V
G
V
A
W
R
Site 22
S217
L
K
N
E
I
P
N
S
H
I
L
D
Q
Y
R
Site 23
Y223
N
S
H
I
L
D
Q
Y
R
N
A
S
N
P
L
Site 24
S227
L
D
Q
Y
R
N
A
S
N
P
L
A
H
Y
D
Site 25
T236
P
L
A
H
Y
D
T
T
A
D
E
I
L
Q
Q
Site 26
S254
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
Site 27
T257
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
Site 28
T262
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
Site 29
T296
E
P
E
E
L
N
Q
T
E
Q
T
T
Y
E
V
Site 30
Y301
N
Q
T
E
Q
T
T
Y
E
V
E
G
I
G
Y
Site 31
T318
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
Site 32
T333
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Site 33
Y381
L
P
D
S
V
R
N
Y
M
T
K
F
L
S
D
Site 34
S476
L
A
G
K
V
Q
P
S
D
Q
V
G
K
V
I
Site 35
T493
Q
F
K
Q
I
R
L
T
D
T
L
G
R
L
S
Site 36
T495
K
Q
I
R
L
T
D
T
L
G
R
L
S
H
I
Site 37
S500
T
D
T
L
G
R
L
S
H
I
L
E
M
D
H
Site 38
Y518
V
V
H
E
Q
I
Q
Y
H
S
T
G
K
S
S
Site 39
S520
H
E
Q
I
Q
Y
H
S
T
G
K
S
S
Q
R
Site 40
S524
Q
Y
H
S
T
G
K
S
S
Q
R
Q
M
V
F
Site 41
S525
Y
H
S
T
G
K
S
S
Q
R
Q
M
V
F
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation