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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLCN1
Full Name:
Chloride channel protein 1
Alias:
Chloride channel 1, skeletal muscle; Chloride channel protein 1; CLC1; Thomsen disease, autosomal dominant
Type:
Channel, chloride
Mass (Da):
108740
Number AA:
988
UniProt ID:
P35523
International Prot ID:
IPI00293558
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034707
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0031404
GO:0005247
PhosphoSite+
KinaseNET
Biological Process:
GO:0006936
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
Q
S
R
S
Q
Q
R
G
G
E
Q
Site 2
S14
Q
Q
R
G
G
E
Q
S
W
W
G
S
D
P
Q
Site 3
Y24
G
S
D
P
Q
Y
Q
Y
M
P
F
E
H
C
T
Site 4
S32
M
P
F
E
H
C
T
S
Y
G
L
P
S
E
N
Site 5
Y33
P
F
E
H
C
T
S
Y
G
L
P
S
E
N
G
Site 6
S70
G
H
H
K
E
Q
F
S
D
R
E
Q
D
I
G
Site 7
T82
D
I
G
M
P
K
K
T
G
S
S
S
T
V
D
Site 8
S84
G
M
P
K
K
T
G
S
S
S
T
V
D
S
K
Site 9
S86
P
K
K
T
G
S
S
S
T
V
D
S
K
D
E
Site 10
T87
K
K
T
G
S
S
S
T
V
D
S
K
D
E
D
Site 11
S90
G
S
S
S
T
V
D
S
K
D
E
D
H
Y
S
Site 12
Y96
D
S
K
D
E
D
H
Y
S
K
C
Q
D
C
I
Site 13
Y137
L
V
S
W
S
M
D
Y
V
S
A
K
S
L
Q
Site 14
S139
S
W
S
M
D
Y
V
S
A
K
S
L
Q
A
Y
Site 15
S142
M
D
Y
V
S
A
K
S
L
Q
A
Y
K
W
S
Site 16
Y146
S
A
K
S
L
Q
A
Y
K
W
S
Y
A
Q
M
Site 17
Y150
L
Q
A
Y
K
W
S
Y
A
Q
M
Q
P
S
L
Site 18
Y257
M
S
V
F
C
G
V
Y
E
Q
P
Y
Y
Y
S
Site 19
Y261
C
G
V
Y
E
Q
P
Y
Y
Y
S
D
I
L
T
Site 20
Y262
G
V
Y
E
Q
P
Y
Y
Y
S
D
I
L
T
V
Site 21
Y296
S
I
E
V
T
S
T
Y
F
A
V
R
N
Y
W
Site 22
S383
V
R
K
H
K
A
L
S
Q
F
L
A
K
H
R
Site 23
T426
M
P
R
E
A
I
S
T
L
F
D
N
N
T
W
Site 24
T432
S
T
L
F
D
N
N
T
W
V
K
H
A
G
D
Site 25
S442
K
H
A
G
D
P
E
S
L
G
Q
S
A
V
W
Site 26
S446
D
P
E
S
L
G
Q
S
A
V
W
I
H
P
R
Site 27
Y578
Q
S
L
Q
P
S
L
Y
D
S
I
I
Q
V
K
Site 28
S580
L
Q
P
S
L
Y
D
S
I
I
Q
V
K
K
L
Site 29
Y589
I
Q
V
K
K
L
P
Y
L
P
D
L
G
W
N
Site 30
Y601
G
W
N
Q
L
S
K
Y
T
I
F
V
E
D
I
Site 31
S617
V
R
D
V
K
F
V
S
A
S
Y
T
Y
G
E
Site 32
S619
D
V
K
F
V
S
A
S
Y
T
Y
G
E
L
R
Site 33
T621
K
F
V
S
A
S
Y
T
Y
G
E
L
R
T
L
Site 34
T631
E
L
R
T
L
L
Q
T
T
T
V
K
T
L
P
Site 35
T636
L
Q
T
T
T
V
K
T
L
P
L
V
D
S
K
Site 36
S642
K
T
L
P
L
V
D
S
K
D
S
M
I
L
L
Site 37
S645
P
L
V
D
S
K
D
S
M
I
L
L
G
S
V
Site 38
S651
D
S
M
I
L
L
G
S
V
E
R
S
E
L
Q
Site 39
S682
Q
E
M
A
R
K
L
S
E
L
P
Y
D
G
K
Site 40
Y686
R
K
L
S
E
L
P
Y
D
G
K
A
R
L
A
Site 41
S707
A
P
P
G
R
P
E
S
F
A
F
V
D
E
D
Site 42
S720
E
D
E
D
E
D
L
S
G
K
S
E
L
P
P
Site 43
S723
D
E
D
L
S
G
K
S
E
L
P
P
S
L
A
Site 44
S728
G
K
S
E
L
P
P
S
L
A
L
H
P
S
T
Site 45
S734
P
S
L
A
L
H
P
S
T
T
A
P
L
S
P
Site 46
T735
S
L
A
L
H
P
S
T
T
A
P
L
S
P
E
Site 47
T736
L
A
L
H
P
S
T
T
A
P
L
S
P
E
E
Site 48
S740
P
S
T
T
A
P
L
S
P
E
E
P
N
G
P
Site 49
S766
E
P
A
G
Q
R
P
S
I
F
Q
S
L
L
H
Site 50
T782
L
L
G
R
A
R
P
T
K
K
K
T
T
Q
D
Site 51
T786
A
R
P
T
K
K
K
T
T
Q
D
S
T
D
L
Site 52
S798
T
D
L
V
D
N
M
S
P
E
E
I
E
A
W
Site 53
S811
A
W
E
Q
E
Q
L
S
Q
P
V
C
F
D
S
Site 54
S824
D
S
C
C
I
D
Q
S
P
F
Q
L
V
E
Q
Site 55
T837
E
Q
T
T
L
H
K
T
H
T
L
F
S
L
L
Site 56
S876
A
I
E
G
H
T
K
S
G
V
Q
L
R
P
P
Site 57
S886
Q
L
R
P
P
L
A
S
F
R
N
T
T
S
T
Site 58
T890
P
L
A
S
F
R
N
T
T
S
T
R
K
S
T
Site 59
T891
L
A
S
F
R
N
T
T
S
T
R
K
S
T
G
Site 60
S892
A
S
F
R
N
T
T
S
T
R
K
S
T
G
A
Site 61
T893
S
F
R
N
T
T
S
T
R
K
S
T
G
A
P
Site 62
S896
N
T
T
S
T
R
K
S
T
G
A
P
P
S
S
Site 63
T897
T
T
S
T
R
K
S
T
G
A
P
P
S
S
A
Site 64
S902
K
S
T
G
A
P
P
S
S
A
E
N
W
N
L
Site 65
S903
S
T
G
A
P
P
S
S
A
E
N
W
N
L
P
Site 66
T917
P
E
D
R
P
G
A
T
G
T
G
D
V
I
A
Site 67
S926
T
G
D
V
I
A
A
S
P
E
T
P
V
P
S
Site 68
T929
V
I
A
A
S
P
E
T
P
V
P
S
P
S
P
Site 69
S933
S
P
E
T
P
V
P
S
P
S
P
E
P
P
L
Site 70
S935
E
T
P
V
P
S
P
S
P
E
P
P
L
S
L
Site 71
S941
P
S
P
E
P
P
L
S
L
A
P
G
K
V
E
Site 72
S959
E
E
L
E
L
V
E
S
P
G
L
E
E
E
L
Site 73
S974
A
D
I
L
Q
G
P
S
L
R
S
T
D
E
E
Site 74
T978
Q
G
P
S
L
R
S
T
D
E
E
D
E
D
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation