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Updated November 2019
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Protein Info
Short Name:
FBN2
Full Name:
Fibrillin-2
Alias:
Type:
Mass (Da):
314775
Number AA:
2912
UniProt ID:
P35556
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S49
P
P
P
Q
Q
V
R
S
A
T
A
G
S
E
G
Site 2
T51
P
Q
Q
V
R
S
A
T
A
G
S
E
G
G
F
Site 3
Y63
G
G
F
L
A
P
E
Y
R
E
E
G
A
A
V
Site 4
S72
E
E
G
A
A
V
A
S
R
V
R
R
R
G
Q
Site 5
T131
C
S
R
P
N
M
C
T
C
S
S
G
Q
I
S
Site 6
S133
R
P
N
M
C
T
C
S
S
G
Q
I
S
S
T
Site 7
S138
T
C
S
S
G
Q
I
S
S
T
C
G
S
K
S
Site 8
S139
C
S
S
G
Q
I
S
S
T
C
G
S
K
S
I
Site 9
T140
S
S
G
Q
I
S
S
T
C
G
S
K
S
I
Q
Site 10
S143
Q
I
S
S
T
C
G
S
K
S
I
Q
Q
C
S
Site 11
S145
S
S
T
C
G
S
K
S
I
Q
Q
C
S
V
R
Site 12
Y211
G
P
Q
C
E
R
D
Y
R
T
G
P
C
F
T
Site 13
T213
Q
C
E
R
D
Y
R
T
G
P
C
F
T
Q
V
Site 14
T237
T
G
I
V
C
T
K
T
L
C
C
A
T
I
G
Site 15
T242
T
K
T
L
C
C
A
T
I
G
R
A
W
G
H
Site 16
T337
E
T
G
E
C
S
N
T
V
G
S
Y
F
C
V
Site 17
Y349
F
C
V
C
P
R
G
Y
V
T
S
T
D
G
S
Site 18
S352
C
P
R
G
Y
V
T
S
T
D
G
S
R
C
I
Site 19
T353
P
R
G
Y
V
T
S
T
D
G
S
R
C
I
D
Site 20
S356
Y
V
T
S
T
D
G
S
R
C
I
D
Q
R
T
Site 21
T363
S
R
C
I
D
Q
R
T
G
M
C
F
S
G
L
Site 22
S410
E
A
C
P
V
R
G
S
E
E
Y
R
R
L
C
Site 23
Y413
P
V
R
G
S
E
E
Y
R
R
L
C
M
D
G
Site 24
S429
P
M
G
G
I
P
G
S
A
G
S
R
P
G
G
Site 25
S432
G
I
P
G
S
A
G
S
R
P
G
G
T
G
G
Site 26
S445
G
G
N
G
F
A
P
S
G
N
G
N
G
Y
G
Site 27
Y451
P
S
G
N
G
N
G
Y
G
P
G
G
T
G
F
Site 28
T513
L
N
G
R
C
I
P
T
V
S
S
Y
R
C
E
Site 29
Y525
R
C
E
C
N
M
G
Y
K
Q
D
A
N
G
D
Site 30
T552
T
N
G
D
C
V
N
T
P
G
S
Y
Y
C
K
Site 31
Y557
V
N
T
P
G
S
Y
Y
C
K
C
H
A
G
F
Site 32
T567
C
H
A
G
F
Q
R
T
P
T
K
Q
A
C
I
Site 33
T569
A
G
F
Q
R
T
P
T
K
Q
A
C
I
D
I
Site 34
T657
A
P
N
G
R
Y
C
T
D
V
D
E
C
Q
T
Site 35
T705
V
D
T
H
M
R
S
T
C
Y
G
G
I
K
K
Site 36
Y791
C
E
N
L
R
G
S
Y
R
C
N
C
N
S
G
Site 37
S797
S
Y
R
C
N
C
N
S
G
Y
E
P
D
A
S
Site 38
Y799
R
C
N
C
N
S
G
Y
E
P
D
A
S
G
R
Site 39
S804
S
G
Y
E
P
D
A
S
G
R
N
C
I
D
I
Site 40
T829
D
N
G
L
C
R
N
T
P
G
S
Y
S
C
T
Site 41
S832
L
C
R
N
T
P
G
S
Y
S
C
T
C
P
P
Site 42
S834
R
N
T
P
G
S
Y
S
C
T
C
P
P
G
Y
Site 43
T836
T
P
G
S
Y
S
C
T
C
P
P
G
Y
V
F
Site 44
Y841
S
C
T
C
P
P
G
Y
V
F
R
T
E
T
E
Site 45
T847
G
Y
V
F
R
T
E
T
E
T
C
E
D
I
N
Site 46
T849
V
F
R
T
E
T
E
T
C
E
D
I
N
E
C
Site 47
S878
G
S
F
N
C
E
C
S
P
G
S
K
L
S
S
Site 48
S881
N
C
E
C
S
P
G
S
K
L
S
S
T
G
L
Site 49
T923
L
K
S
E
C
C
A
T
L
G
A
A
W
G
S
Site 50
S930
T
L
G
A
A
W
G
S
P
C
E
R
C
E
L
Site 51
T939
C
E
R
C
E
L
D
T
A
C
P
R
G
L
A
Site 52
T952
L
A
R
I
K
G
V
T
C
E
D
V
N
E
C
Site 53
Y1004
D
I
R
M
E
Q
C
Y
L
K
W
D
E
D
E
Site 54
Y1048
P
K
P
G
T
K
E
Y
E
T
L
C
P
R
G
Site 55
T1050
P
G
T
K
E
Y
E
T
L
C
P
R
G
A
G
Site 56
T1066
A
N
R
G
D
V
L
T
G
R
P
F
Y
K
D
Site 57
Y1071
V
L
T
G
R
P
F
Y
K
D
I
N
E
C
K
Site 58
S1122
D
I
D
E
C
R
I
S
P
D
L
C
G
S
G
Site 59
T1134
G
S
G
I
C
V
N
T
P
G
S
F
E
C
E
Site 60
T1173
P
L
L
C
R
G
G
T
C
V
N
T
E
G
S
Site 61
T1177
R
G
G
T
C
V
N
T
E
G
S
F
Q
C
D
Site 62
S1192
C
P
L
G
H
E
L
S
P
S
R
E
D
C
V
Site 63
S1194
L
G
H
E
L
S
P
S
R
E
D
C
V
D
I
Site 64
S1207
D
I
N
E
C
S
L
S
D
N
L
C
R
N
G
Site 65
Y1231
Q
C
S
C
N
P
G
Y
Q
A
T
P
D
R
Q
Site 66
T1234
C
N
P
G
Y
Q
A
T
P
D
R
Q
G
C
T
Site 67
T1258
G
G
C
D
T
Q
C
T
N
S
E
G
S
Y
E
Site 68
S1263
Q
C
T
N
S
E
G
S
Y
E
C
S
C
S
E
Site 69
Y1264
C
T
N
S
E
G
S
Y
E
C
S
C
S
E
G
Site 70
S1267
S
E
G
S
Y
E
C
S
C
S
E
G
Y
A
L
Site 71
S1269
G
S
Y
E
C
S
C
S
E
G
Y
A
L
M
P
Site 72
S1390
S
C
L
N
I
P
G
S
F
K
C
S
C
R
E
Site 73
T1428
I
N
A
Q
C
V
N
T
P
G
S
Y
R
C
A
Site 74
S1437
G
S
Y
R
C
A
C
S
E
G
F
T
G
D
G
Site 75
T1446
G
F
T
G
D
G
F
T
C
S
D
V
D
E
C
Site 76
S1448
T
G
D
G
F
T
C
S
D
V
D
E
C
A
E
Site 77
T1481
C
E
C
E
M
G
F
T
P
A
S
D
S
R
S
Site 78
S1484
E
M
G
F
T
P
A
S
D
S
R
S
C
Q
D
Site 79
S1486
G
F
T
P
A
S
D
S
R
S
C
Q
D
I
D
Site 80
S1488
T
P
A
S
D
S
R
S
C
Q
D
I
D
E
C
Site 81
Y1521
H
C
I
C
D
D
G
Y
E
L
D
R
T
G
G
Site 82
T1526
D
G
Y
E
L
D
R
T
G
G
N
C
T
D
I
Site 83
T1550
V
N
G
L
C
V
N
T
P
G
R
Y
E
C
N
Site 84
Y1554
C
V
N
T
P
G
R
Y
E
C
N
C
P
P
D
Site 85
Y1580
D
N
R
V
G
N
C
Y
L
K
F
G
P
R
G
Site 86
S1590
F
G
P
R
G
D
G
S
L
S
C
N
T
E
I
Site 87
S1592
P
R
G
D
G
S
L
S
C
N
T
E
I
G
V
Site 88
S1609
S
R
S
S
C
C
C
S
L
G
K
A
W
G
N
Site 89
Y1629
P
P
V
N
S
T
E
Y
Y
T
L
C
P
G
G
Site 90
Y1630
P
V
N
S
T
E
Y
Y
T
L
C
P
G
G
E
Site 91
T1631
V
N
S
T
E
Y
Y
T
L
C
P
G
G
E
G
Site 92
Y1709
V
C
G
P
G
T
C
Y
N
T
L
G
N
Y
T
Site 93
Y1715
C
Y
N
T
L
G
N
Y
T
C
I
C
P
P
E
Site 94
Y1741
D
M
R
K
S
F
C
Y
R
S
Y
N
G
T
T
Site 95
Y1744
K
S
F
C
Y
R
S
Y
N
G
T
T
C
E
N
Site 96
T1781
K
P
C
E
P
C
P
T
P
G
T
A
D
F
K
Site 97
T1784
E
P
C
P
T
P
G
T
A
D
F
K
T
I
C
Site 98
T1789
P
G
T
A
D
F
K
T
I
C
G
N
I
P
G
Site 99
S1870
R
N
A
D
C
I
N
S
P
G
S
Y
R
C
E
Site 100
Y1915
C
V
D
L
Q
G
S
Y
Q
C
I
C
H
N
G
Site 101
Y1960
G
S
Y
N
C
L
C
Y
P
G
F
E
L
T
H
Site 102
Y2005
K
C
L
C
N
E
G
Y
E
L
T
P
D
G
K
Site 103
T2008
C
N
E
G
Y
E
L
T
P
D
G
K
N
C
I
Site 104
T2017
D
G
K
N
C
I
D
T
N
E
C
V
A
L
P
Site 105
T2031
P
G
S
C
S
P
G
T
C
Q
N
L
E
G
S
Site 106
Y2047
R
C
I
C
P
P
G
Y
E
V
K
S
E
N
C
Site 107
S2090
C
P
P
G
F
V
L
S
D
N
G
R
R
C
F
Site 108
T2121
S
V
P
K
A
F
N
T
T
K
A
K
C
C
C
Site 109
T2161
L
C
P
Y
G
H
G
T
V
P
S
L
H
D
T
Site 110
S2164
Y
G
H
G
T
V
P
S
L
H
D
T
R
E
D
Site 111
T2168
T
V
P
S
L
H
D
T
R
E
D
V
N
E
C
Site 112
S2178
D
V
N
E
C
L
E
S
P
G
I
C
S
N
G
Site 113
T2190
S
N
G
Q
C
I
N
T
D
G
S
F
R
C
E
Site 114
Y2202
R
C
E
C
P
M
G
Y
N
L
D
Y
T
G
V
Site 115
Y2206
P
M
G
Y
N
L
D
Y
T
G
V
R
C
V
D
Site 116
T2214
T
G
V
R
C
V
D
T
D
E
C
S
I
G
N
Site 117
S2371
E
C
N
E
G
F
Q
S
S
S
S
G
T
E
C
Site 118
S2372
C
N
E
G
F
Q
S
S
S
S
G
T
E
C
L
Site 119
S2374
E
G
F
Q
S
S
S
S
G
T
E
C
L
D
N
Site 120
T2376
F
Q
S
S
S
S
G
T
E
C
L
D
N
R
Q
Site 121
S2400
T
I
C
Q
M
A
S
S
S
R
N
L
V
T
K
Site 122
S2401
I
C
Q
M
A
S
S
S
R
N
L
V
T
K
S
Site 123
T2406
S
S
S
R
N
L
V
T
K
S
E
C
C
C
D
Site 124
Y2433
P
L
P
G
T
A
Q
Y
K
K
I
C
P
H
G
Site 125
Y2443
I
C
P
H
G
P
G
Y
T
T
D
G
R
D
I
Site 126
Y2480
R
C
F
C
K
V
G
Y
T
T
D
I
S
G
T
Site 127
S2498
D
L
D
E
C
S
Q
S
P
K
P
C
N
Y
I
Site 128
Y2504
Q
S
P
K
P
C
N
Y
I
C
K
N
T
E
G
Site 129
Y2513
C
K
N
T
E
G
S
Y
Q
C
S
C
P
R
G
Site 130
S2516
T
E
G
S
Y
Q
C
S
C
P
R
G
Y
V
L
Site 131
Y2521
Q
C
S
C
P
R
G
Y
V
L
Q
E
D
G
K
Site 132
T2529
V
L
Q
E
D
G
K
T
C
K
D
L
D
E
C
Site 133
S2577
I
D
N
N
E
C
G
S
Q
P
S
L
C
G
A
Site 134
S2580
N
E
C
G
S
Q
P
S
L
C
G
A
K
G
I
Site 135
T2591
A
K
G
I
C
Q
N
T
P
G
S
F
S
C
E
Site 136
S2604
C
E
C
Q
R
G
F
S
L
D
A
T
G
L
N
Site 137
T2608
R
G
F
S
L
D
A
T
G
L
N
C
E
D
V
Site 138
Y2635
C
Q
N
I
L
G
G
Y
R
C
G
C
P
Q
G
Site 139
S2666
S
N
P
N
A
C
G
S
A
S
C
Y
N
T
L
Site 140
S2668
P
N
A
C
G
S
A
S
C
Y
N
T
L
G
S
Site 141
Y2670
A
C
G
S
A
S
C
Y
N
T
L
G
S
Y
K
Site 142
T2672
G
S
A
S
C
Y
N
T
L
G
S
Y
K
C
A
Site 143
Y2676
C
Y
N
T
L
G
S
Y
K
C
A
C
P
S
G
Site 144
S2682
S
Y
K
C
A
C
P
S
G
F
S
F
D
Q
F
Site 145
Y2708
S
S
K
N
P
C
N
Y
G
C
S
N
T
E
G
Site 146
Y2717
C
S
N
T
E
G
G
Y
L
C
G
C
P
P
G
Site 147
Y2725
L
C
G
C
P
P
G
Y
Y
R
V
G
Q
G
H
Site 148
Y2744
M
G
F
N
K
G
Q
Y
L
S
L
D
T
E
V
Site 149
S2746
F
N
K
G
Q
Y
L
S
L
D
T
E
V
D
E
Site 150
S2758
V
D
E
E
N
A
L
S
P
E
A
C
Y
E
C
Site 151
Y2763
A
L
S
P
E
A
C
Y
E
C
K
I
N
G
Y
Site 152
S2771
E
C
K
I
N
G
Y
S
K
K
D
S
R
Q
K
Site 153
S2775
N
G
Y
S
K
K
D
S
R
Q
K
R
S
I
H
Site 154
T2787
S
I
H
E
P
D
P
T
A
V
E
Q
I
S
L
Site 155
S2793
P
T
A
V
E
Q
I
S
L
E
S
V
D
M
D
Site 156
S2801
L
E
S
V
D
M
D
S
P
V
N
M
K
F
N
Site 157
S2810
V
N
M
K
F
N
L
S
H
L
G
S
K
E
H
Site 158
S2814
F
N
L
S
H
L
G
S
K
E
H
I
L
E
L
Site 159
Y2834
P
L
N
N
H
I
R
Y
V
I
S
Q
G
N
D
Site 160
S2837
N
H
I
R
Y
V
I
S
Q
G
N
D
D
S
V
Site 161
S2843
I
S
Q
G
N
D
D
S
V
F
R
I
H
Q
R
Site 162
Y2855
H
Q
R
N
G
L
S
Y
L
H
T
A
K
K
K
Site 163
T2858
N
G
L
S
Y
L
H
T
A
K
K
K
L
M
P
Site 164
Y2868
K
K
L
M
P
G
T
Y
T
L
E
I
T
S
I
Site 165
T2869
K
L
M
P
G
T
Y
T
L
E
I
T
S
I
P
Site 166
T2873
G
T
Y
T
L
E
I
T
S
I
P
L
Y
K
K
Site 167
S2874
T
Y
T
L
E
I
T
S
I
P
L
Y
K
K
K
Site 168
Y2878
E
I
T
S
I
P
L
Y
K
K
K
E
L
K
K
Site 169
Y2894
E
E
S
N
E
D
D
Y
L
L
G
E
L
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation