PhosphoNET

           
Protein Info 
   
Short Name:  G6PC
Full Name:  Glucose-6-phosphatase
Alias:  EC 3.1.3.9; G6Pase; G-6-Pase; G6PT; Glucose-6-phosphatase, catalytic; Glucose-6-phosphatase, catalytic subunit; Glycogen storage disease type I, von Gierke disease; GSD1a
Type:  Membrane protein, integral; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - galactose; Phosphatase (non-protein); Endoplasmic reticulum; Carbohydrate Metabolism - starch and sucrose; EC 3.1.3.9
Mass (Da):  40514
Number AA:  357
UniProt ID:  P35575
International Prot ID:  IPI00019500
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0030176     Uniprot OncoNet
Molecular Function:  GO:0004346  GO:0042301   PhosphoSite+ KinaseNET
Biological Process:  GO:0006094  GO:0042593   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y18FGIQSTHYLQVNYQD
Site 2Y85ILFGQRPYWWVLDTD
Site 3Y93WWVLDTDYYSNTSVP
Site 4Y94WVLDTDYYSNTSVPL
Site 5T97DTDYYSNTSVPLIKQ
Site 6T108LIKQFPVTCETGPGS
Site 7T111QFPVTCETGPGSPSG
Site 8S115TCETGPGSPSGHAMG
Site 9Y146QGKIKPTYRFRCLNV
Site 10S200ETFSHIHSIYNASLK
Site 11Y202FSHIHSIYNASLKKY
Site 12T237LGVDLLWTLEKAQRW
Site 13S278LGLALNSSMYRESCK
Site 14Y280LALNSSMYRESCKGK
Site 15S283NSSMYRESCKGKLSK
Site 16S289ESCKGKLSKWLPFRL
Site 17S316FDSLKPPSQVELVFY
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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