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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SOAT1
Full Name:
Sterol O-acyltransferase 1
Alias:
ACACT; ACACT1; ACAT; ACAT1; ACAT-1; Acyl coenzyme A:cholesterol acyltransferase 1; Acyl coenzyme A;cholesterol acyltransferase 1; Acyl-Coenzyme A: cholesterol acyltransferase; Cholesterol acyltransferase 1; EC 2.3.1.26; SOAT; STAT
Type:
Transferase, Lipid Metabolism group, Bile acid biosynthesis family
Mass (Da):
64735
Number AA:
550
UniProt ID:
P35610
International Prot ID:
IPI00745125
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0016021
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0000062
GO:0034736
GO:0015485
PhosphoSite+
KinaseNET
Biological Process:
GO:0033344
GO:0034435
GO:0042632
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
V
G
E
E
K
M
S
L
R
N
R
L
S
K
Site 2
S14
M
S
L
R
N
R
L
S
K
S
R
E
N
P
E
Site 3
S16
L
R
N
R
L
S
K
S
R
E
N
P
E
E
D
Site 4
S33
Q
R
N
P
A
K
E
S
L
E
T
P
S
N
G
Site 5
T36
P
A
K
E
S
L
E
T
P
S
N
G
R
I
D
Site 6
T78
S
H
F
D
D
F
V
T
N
L
I
E
K
S
A
Site 7
S84
V
T
N
L
I
E
K
S
A
S
L
D
N
G
G
Site 8
S86
N
L
I
E
K
S
A
S
L
D
N
G
G
C
A
Site 9
T208
F
L
F
Q
H
W
A
T
G
Y
S
K
S
S
H
Site 10
S211
Q
H
W
A
T
G
Y
S
K
S
S
H
P
L
I
Site 11
S213
W
A
T
G
Y
S
K
S
S
H
P
L
I
R
S
Site 12
S269
R
F
V
M
K
A
H
S
F
V
R
E
N
V
P
Site 13
S281
N
V
P
R
V
L
N
S
A
K
E
K
S
S
T
Site 14
T288
S
A
K
E
K
S
S
T
V
P
I
P
T
V
N
Site 15
S311
P
T
L
I
Y
R
D
S
Y
P
R
N
P
T
V
Site 16
Y312
T
L
I
Y
R
D
S
Y
P
R
N
P
T
V
R
Site 17
T317
D
S
Y
P
R
N
P
T
V
R
W
G
Y
V
A
Site 18
Y322
N
P
T
V
R
W
G
Y
V
A
M
K
F
A
Q
Site 19
Y416
N
S
T
S
Y
S
N
Y
Y
R
T
W
N
V
V
Site 20
Y430
V
V
H
D
W
L
Y
Y
Y
A
Y
K
D
F
L
Site 21
Y518
N
G
V
L
L
C
F
Y
S
Q
E
W
Y
A
R
Site 22
Y538
K
N
P
T
F
L
D
Y
V
R
P
R
S
W
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation