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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADRBK2
Full Name:
Beta-adrenergic receptor kinase 2
Alias:
Adrenergic, beta, receptor kinase 2; ARBK2; BARK2; Beta-adrenergic receptor kinase 2; Beta-ARK-2; EC 2.7.11.15; G-protein coupled receptor kinase 3
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.15; AGC group; GRK family; BARK subfamily
Mass (Da):
79710
Number AA:
688
UniProt ID:
P35626
International Prot ID:
IPI00019926
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0047696
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
A
V
L
A
D
V
S
Y
L
M
A
M
E
K
S
Site 2
T23
A
M
E
K
S
K
A
T
P
A
A
R
A
S
K
Site 3
S29
A
T
P
A
A
R
A
S
K
R
I
V
L
P
E
Site 4
S38
R
I
V
L
P
E
P
S
I
R
S
V
M
Q
K
Site 5
Y46
I
R
S
V
M
Q
K
Y
L
A
E
R
N
E
I
Site 6
Y86
A
V
P
Q
V
K
F
Y
E
E
I
K
E
Y
E
Site 7
Y92
F
Y
E
E
I
K
E
Y
E
K
L
D
N
E
E
Site 8
Y109
L
C
R
S
R
Q
I
Y
D
A
Y
I
M
K
E
Site 9
Y112
S
R
Q
I
Y
D
A
Y
I
M
K
E
L
L
S
Site 10
S119
Y
I
M
K
E
L
L
S
C
S
H
P
F
S
K
Site 11
S121
M
K
E
L
L
S
C
S
H
P
F
S
K
Q
A
Site 12
S125
L
S
C
S
H
P
F
S
K
Q
A
V
E
H
V
Site 13
S134
Q
A
V
E
H
V
Q
S
H
L
S
K
K
Q
V
Site 14
S137
E
H
V
Q
S
H
L
S
K
K
Q
V
T
S
T
Site 15
Y206
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
T
Site 16
Y217
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
Site 17
Y281
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
V
Site 18
S284
G
D
L
H
Y
H
L
S
Q
H
G
V
F
S
E
Site 19
Y297
S
E
K
E
M
R
F
Y
A
T
E
I
I
L
G
Site 20
S334
E
H
G
H
A
R
I
S
D
L
G
L
A
C
D
Site 21
S343
L
G
L
A
C
D
F
S
K
K
K
P
H
A
S
Site 22
S350
S
K
K
K
P
H
A
S
V
G
T
H
G
Y
M
Site 23
T353
K
P
H
A
S
V
G
T
H
G
Y
M
A
P
E
Site 24
Y356
A
S
V
G
T
H
G
Y
M
A
P
E
V
L
Q
Site 25
T366
P
E
V
L
Q
K
G
T
A
Y
D
S
S
A
D
Site 26
Y368
V
L
Q
K
G
T
A
Y
D
S
S
A
D
W
F
Site 27
S370
Q
K
G
T
A
Y
D
S
S
A
D
W
F
S
L
Site 28
S371
K
G
T
A
Y
D
S
S
A
D
W
F
S
L
G
Site 29
S389
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
Site 30
T396
S
P
F
R
Q
H
K
T
K
D
K
H
E
I
D
Site 31
T406
K
H
E
I
D
R
M
T
L
T
V
N
V
E
L
Site 32
T408
E
I
D
R
M
T
L
T
V
N
V
E
L
P
D
Site 33
T416
V
N
V
E
L
P
D
T
F
S
P
E
L
K
S
Site 34
S423
T
F
S
P
E
L
K
S
L
L
E
G
L
L
Q
Site 35
S434
G
L
L
Q
R
D
V
S
K
R
L
G
C
H
G
Site 36
S444
L
G
C
H
G
G
G
S
Q
E
V
K
E
H
S
Site 37
S451
S
Q
E
V
K
E
H
S
F
F
K
G
V
D
W
Site 38
Y462
G
V
D
W
Q
H
V
Y
L
Q
K
Y
P
P
P
Site 39
Y466
Q
H
V
Y
L
Q
K
Y
P
P
P
L
I
P
P
Site 40
S487
A
D
A
F
D
I
G
S
F
D
E
E
D
T
K
Site 41
T493
G
S
F
D
E
E
D
T
K
G
I
K
L
L
D
Site 42
S514
K
N
F
P
L
V
I
S
E
R
W
Q
Q
E
V
Site 43
T524
W
Q
Q
E
V
T
E
T
V
Y
E
A
V
N
A
Site 44
Y526
Q
E
V
T
E
T
V
Y
E
A
V
N
A
D
T
Site 45
Y553
Q
L
G
H
E
E
D
Y
A
L
G
K
D
C
I
Site 46
Y564
K
D
C
I
M
H
G
Y
M
L
K
L
G
N
P
Site 47
Y580
L
T
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
Site 48
Y582
Q
W
Q
R
R
Y
F
Y
L
F
P
N
R
L
E
Site 49
S596
E
W
R
G
E
G
E
S
R
Q
N
L
L
T
M
Site 50
T602
E
S
R
Q
N
L
L
T
M
E
Q
I
L
S
V
Site 51
S608
L
T
M
E
Q
I
L
S
V
E
E
T
Q
I
K
Site 52
T612
Q
I
L
S
V
E
E
T
Q
I
K
D
K
K
C
Site 53
T650
W
K
K
E
L
N
E
T
F
K
E
A
Q
R
L
Site 54
S670
K
F
L
N
K
P
R
S
G
T
V
E
L
P
K
Site 55
T672
L
N
K
P
R
S
G
T
V
E
L
P
K
P
S
Site 56
S679
T
V
E
L
P
K
P
S
L
C
H
R
N
S
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation