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Updated November 2019
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Protein Info
Short Name:
NUP214
Full Name:
Nuclear pore complex protein Nup214
Alias:
214 kDa nucleoporin; CAIN; CAN; CAN protein; CAN protein, putative oncogene; D9S46E; N214; NU214; Nuclear pore complex protein Nup214; Nucleoporin 214kDa; Nucleoporin 214kDa (CAN); Nucleoporin Nup214
Type:
Transport protein, facilitator
Mass (Da):
213620
Number AA:
2090
UniProt ID:
P35658
International Prot ID:
IPI00183294
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005643
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0051028
GO:0006611
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
K
K
V
R
I
F
D
S
P
E
E
L
P
K
E
Site 2
S39
E
E
L
P
K
E
R
S
S
L
L
A
V
S
N
Site 3
S40
E
L
P
K
E
R
S
S
L
L
A
V
S
N
K
Site 4
S45
R
S
S
L
L
A
V
S
N
K
Y
G
L
V
F
Site 5
Y48
L
L
A
V
S
N
K
Y
G
L
V
F
A
G
G
Site 6
T127
I
A
F
F
D
V
R
T
F
S
N
E
A
K
Q
Site 7
S129
F
F
D
V
R
T
F
S
N
E
A
K
Q
Q
K
Site 8
S201
A
V
T
S
V
C
W
S
P
K
G
K
Q
L
A
Site 9
T215
A
V
G
K
Q
N
G
T
V
V
Q
Y
L
P
T
Site 10
Y235
V
I
P
C
P
P
F
Y
E
S
D
H
P
V
R
Site 11
S237
P
C
P
P
F
Y
E
S
D
H
P
V
R
V
L
Site 12
Y295
V
N
F
M
E
P
C
Y
G
S
C
T
E
R
Q
Site 13
Y305
C
T
E
R
Q
H
H
Y
Y
L
S
Y
I
E
E
Site 14
Y306
T
E
R
Q
H
H
Y
Y
L
S
Y
I
E
E
W
Site 15
S327
S
A
A
S
T
E
V
S
I
L
A
R
Q
S
D
Site 16
S333
V
S
I
L
A
R
Q
S
D
Q
I
N
W
E
S
Site 17
S346
E
S
W
L
L
E
D
S
S
R
A
E
L
P
V
Site 18
S347
S
W
L
L
E
D
S
S
R
A
E
L
P
V
T
Site 19
T354
S
R
A
E
L
P
V
T
D
K
S
D
D
S
L
Site 20
S357
E
L
P
V
T
D
K
S
D
D
S
L
P
M
G
Site 21
S378
N
Q
V
E
I
T
I
S
D
E
K
T
L
P
P
Site 22
Y402
D
G
V
L
C
P
F
Y
M
I
N
Q
N
P
G
Site 23
S412
N
Q
N
P
G
V
K
S
L
I
K
T
P
E
R
Site 24
T416
G
V
K
S
L
I
K
T
P
E
R
L
S
L
E
Site 25
S421
I
K
T
P
E
R
L
S
L
E
G
E
R
Q
P
Site 26
S430
E
G
E
R
Q
P
K
S
P
G
S
T
P
T
T
Site 27
S433
R
Q
P
K
S
P
G
S
T
P
T
T
P
T
S
Site 28
T434
Q
P
K
S
P
G
S
T
P
T
T
P
T
S
S
Site 29
T436
K
S
P
G
S
T
P
T
T
P
T
S
S
Q
A
Site 30
T437
S
P
G
S
T
P
T
T
P
T
S
S
Q
A
P
Site 31
T439
G
S
T
P
T
T
P
T
S
S
Q
A
P
Q
K
Site 32
S440
S
T
P
T
T
P
T
S
S
Q
A
P
Q
K
L
Site 33
S441
T
P
T
T
P
T
S
S
Q
A
P
Q
K
L
D
Site 34
S450
A
P
Q
K
L
D
A
S
A
A
A
A
P
A
S
Site 35
S461
A
P
A
S
L
P
P
S
S
P
A
A
P
I
A
Site 36
S486
P
T
V
F
S
F
G
S
S
S
L
K
S
S
A
Site 37
S487
T
V
F
S
F
G
S
S
S
L
K
S
S
A
T
Site 38
S491
F
G
S
S
S
L
K
S
S
A
T
V
T
G
E
Site 39
S492
G
S
S
S
L
K
S
S
A
T
V
T
G
E
P
Site 40
T494
S
S
L
K
S
S
A
T
V
T
G
E
P
P
S
Site 41
T496
L
K
S
S
A
T
V
T
G
E
P
P
S
Y
S
Site 42
S501
T
V
T
G
E
P
P
S
Y
S
S
G
S
D
S
Site 43
Y502
V
T
G
E
P
P
S
Y
S
S
G
S
D
S
S
Site 44
S503
T
G
E
P
P
S
Y
S
S
G
S
D
S
S
K
Site 45
S504
G
E
P
P
S
Y
S
S
G
S
D
S
S
K
A
Site 46
S506
P
P
S
Y
S
S
G
S
D
S
S
K
A
A
P
Site 47
S508
S
Y
S
S
G
S
D
S
S
K
A
A
P
G
P
Site 48
S509
Y
S
S
G
S
D
S
S
K
A
A
P
G
P
G
Site 49
T519
A
P
G
P
G
P
S
T
F
S
F
V
P
P
S
Site 50
S521
G
P
G
P
S
T
F
S
F
V
P
P
S
K
A
Site 51
S547
A
P
S
A
A
S
F
S
F
G
S
S
G
F
K
Site 52
S551
A
S
F
S
F
G
S
S
G
F
K
P
T
L
E
Site 53
T556
G
S
S
G
F
K
P
T
L
E
S
T
P
V
P
Site 54
S559
G
F
K
P
T
L
E
S
T
P
V
P
S
V
S
Site 55
T560
F
K
P
T
L
E
S
T
P
V
P
S
V
S
A
Site 56
S575
P
N
I
A
M
K
P
S
F
P
P
S
T
S
A
Site 57
S579
M
K
P
S
F
P
P
S
T
S
A
V
K
V
N
Site 58
T580
K
P
S
F
P
P
S
T
S
A
V
K
V
N
L
Site 59
S581
P
S
F
P
P
S
T
S
A
V
K
V
N
L
S
Site 60
T592
V
N
L
S
E
K
F
T
A
A
A
T
S
T
P
Site 61
T596
E
K
F
T
A
A
A
T
S
T
P
V
S
S
S
Site 62
S597
K
F
T
A
A
A
T
S
T
P
V
S
S
S
Q
Site 63
T598
F
T
A
A
A
T
S
T
P
V
S
S
S
Q
S
Site 64
S601
A
A
T
S
T
P
V
S
S
S
Q
S
A
P
P
Site 65
S602
A
T
S
T
P
V
S
S
S
Q
S
A
P
P
M
Site 66
S603
T
S
T
P
V
S
S
S
Q
S
A
P
P
M
S
Site 67
S605
T
P
V
S
S
S
Q
S
A
P
P
M
S
P
F
Site 68
S610
S
Q
S
A
P
P
M
S
P
F
S
S
A
S
K
Site 69
S613
A
P
P
M
S
P
F
S
S
A
S
K
P
A
A
Site 70
S614
P
P
M
S
P
F
S
S
A
S
K
P
A
A
S
Site 71
S616
M
S
P
F
S
S
A
S
K
P
A
A
S
G
P
Site 72
S621
S
A
S
K
P
A
A
S
G
P
L
S
H
P
T
Site 73
S625
P
A
A
S
G
P
L
S
H
P
T
P
L
S
A
Site 74
T628
S
G
P
L
S
H
P
T
P
L
S
A
P
P
S
Site 75
S631
L
S
H
P
T
P
L
S
A
P
P
S
S
V
P
Site 76
S635
T
P
L
S
A
P
P
S
S
V
P
L
K
S
S
Site 77
S636
P
L
S
A
P
P
S
S
V
P
L
K
S
S
V
Site 78
S641
P
S
S
V
P
L
K
S
S
V
L
P
S
P
S
Site 79
S642
S
S
V
P
L
K
S
S
V
L
P
S
P
S
G
Site 80
S646
L
K
S
S
V
L
P
S
P
S
G
R
S
A
Q
Site 81
S648
S
S
V
L
P
S
P
S
G
R
S
A
Q
G
S
Site 82
S651
L
P
S
P
S
G
R
S
A
Q
G
S
S
S
P
Site 83
S655
S
G
R
S
A
Q
G
S
S
S
P
V
P
S
M
Site 84
S656
G
R
S
A
Q
G
S
S
S
P
V
P
S
M
V
Site 85
S657
R
S
A
Q
G
S
S
S
P
V
P
S
M
V
Q
Site 86
S661
G
S
S
S
P
V
P
S
M
V
Q
K
S
P
R
Site 87
S666
V
P
S
M
V
Q
K
S
P
R
I
T
P
P
A
Site 88
T670
V
Q
K
S
P
R
I
T
P
P
A
A
K
P
G
Site 89
S678
P
P
A
A
K
P
G
S
P
Q
A
K
S
L
Q
Site 90
S683
P
G
S
P
Q
A
K
S
L
Q
P
A
V
A
E
Site 91
S725
E
E
L
K
A
R
T
S
K
A
C
F
Q
V
G
Site 92
T742
E
E
M
K
M
L
R
T
E
S
D
D
L
H
T
Site 93
S744
M
K
M
L
R
T
E
S
D
D
L
H
T
F
L
Site 94
T749
T
E
S
D
D
L
H
T
F
L
L
E
I
K
E
Site 95
T757
F
L
L
E
I
K
E
T
T
E
S
L
H
G
D
Site 96
S760
E
I
K
E
T
T
E
S
L
H
G
D
I
S
S
Site 97
S766
E
S
L
H
G
D
I
S
S
L
K
T
T
L
L
Site 98
S767
S
L
H
G
D
I
S
S
L
K
T
T
L
L
E
Site 99
S792
Q
N
E
R
N
R
D
S
G
Y
L
H
L
L
Y
Site 100
Y794
E
R
N
R
D
S
G
Y
L
H
L
L
Y
K
R
Site 101
Y799
S
G
Y
L
H
L
L
Y
K
R
P
L
D
P
K
Site 102
S807
K
R
P
L
D
P
K
S
E
A
Q
L
Q
E
I
Site 103
Y820
E
I
R
R
L
H
Q
Y
V
K
F
A
V
Q
D
Site 104
T856
L
L
V
P
E
R
E
T
L
F
N
T
L
A
N
Site 105
S881
R
L
N
H
L
V
D
S
L
Q
Q
L
R
L
Y
Site 106
Y888
S
L
Q
Q
L
R
L
Y
K
Q
T
S
L
W
S
Site 107
T891
Q
L
R
L
Y
K
Q
T
S
L
W
S
L
S
S
Site 108
S892
L
R
L
Y
K
Q
T
S
L
W
S
L
S
S
A
Site 109
S895
Y
K
Q
T
S
L
W
S
L
S
S
A
V
P
S
Site 110
S897
Q
T
S
L
W
S
L
S
S
A
V
P
S
Q
S
Site 111
S898
T
S
L
W
S
L
S
S
A
V
P
S
Q
S
S
Site 112
S902
S
L
S
S
A
V
P
S
Q
S
S
I
H
S
F
Site 113
S904
S
S
A
V
P
S
Q
S
S
I
H
S
F
D
S
Site 114
S905
S
A
V
P
S
Q
S
S
I
H
S
F
D
S
D
Site 115
S908
P
S
Q
S
S
I
H
S
F
D
S
D
L
E
S
Site 116
S911
S
S
I
H
S
F
D
S
D
L
E
S
L
C
N
Site 117
S915
S
F
D
S
D
L
E
S
L
C
N
A
L
L
K
Site 118
T923
L
C
N
A
L
L
K
T
T
I
E
S
H
T
K
Site 119
S927
L
L
K
T
T
I
E
S
H
T
K
S
L
P
K
Site 120
S931
T
I
E
S
H
T
K
S
L
P
K
V
P
A
K
Site 121
S940
P
K
V
P
A
K
L
S
P
M
K
Q
A
Q
L
Site 122
T956
N
F
L
A
K
R
K
T
P
P
V
R
S
T
A
Site 123
S961
R
K
T
P
P
V
R
S
T
A
P
A
S
L
S
Site 124
T962
K
T
P
P
V
R
S
T
A
P
A
S
L
S
R
Site 125
S966
V
R
S
T
A
P
A
S
L
S
R
S
A
F
L
Site 126
S968
S
T
A
P
A
S
L
S
R
S
A
F
L
S
Q
Site 127
S970
A
P
A
S
L
S
R
S
A
F
L
S
Q
R
Y
Site 128
S974
L
S
R
S
A
F
L
S
Q
R
Y
Y
E
D
L
Site 129
Y978
A
F
L
S
Q
R
Y
Y
E
D
L
D
E
V
S
Site 130
S985
Y
E
D
L
D
E
V
S
S
T
S
S
V
S
Q
Site 131
S986
E
D
L
D
E
V
S
S
T
S
S
V
S
Q
S
Site 132
T987
D
L
D
E
V
S
S
T
S
S
V
S
Q
S
L
Site 133
S988
L
D
E
V
S
S
T
S
S
V
S
Q
S
L
E
Site 134
S989
D
E
V
S
S
T
S
S
V
S
Q
S
L
E
S
Site 135
S991
V
S
S
T
S
S
V
S
Q
S
L
E
S
E
D
Site 136
S993
S
T
S
S
V
S
Q
S
L
E
S
E
D
A
R
Site 137
S996
S
V
S
Q
S
L
E
S
E
D
A
R
T
S
C
Site 138
T1001
L
E
S
E
D
A
R
T
S
C
K
D
D
E
A
Site 139
S1002
E
S
E
D
A
R
T
S
C
K
D
D
E
A
V
Site 140
T1021
R
H
A
P
V
V
R
T
P
S
I
Q
P
S
L
Site 141
S1023
A
P
V
V
R
T
P
S
I
Q
P
S
L
L
P
Site 142
S1027
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G
G
G
L
F
G
Q
Site 294
S1801
G
G
G
L
F
G
Q
S
N
A
P
A
F
G
Q
Site 295
S1809
N
A
P
A
F
G
Q
S
P
G
F
G
Q
G
G
Site 296
S1817
P
G
F
G
Q
G
G
S
V
F
G
G
T
S
A
Site 297
S1840
G
F
S
F
C
Q
A
S
G
F
G
S
S
N
T
Site 298
S1844
C
Q
A
S
G
F
G
S
S
N
T
G
S
V
F
Site 299
S1845
Q
A
S
G
F
G
S
S
N
T
G
S
V
F
G
Site 300
T1847
S
G
F
G
S
S
N
T
G
S
V
F
G
Q
A
Site 301
S1849
F
G
S
S
N
T
G
S
V
F
G
Q
A
A
S
Site 302
S1866
G
I
V
F
G
Q
Q
S
S
S
S
S
G
S
V
Site 303
S1868
V
F
G
Q
Q
S
S
S
S
S
G
S
V
F
G
Site 304
S1869
F
G
Q
Q
S
S
S
S
S
G
S
V
F
G
S
Site 305
S1870
G
Q
Q
S
S
S
S
S
G
S
V
F
G
S
G
Site 306
S1872
Q
S
S
S
S
S
G
S
V
F
G
S
G
N
T
Site 307
S1876
S
S
G
S
V
F
G
S
G
N
T
G
R
G
G
Site 308
T1879
S
V
F
G
S
G
N
T
G
R
G
G
G
F
F
Site 309
S1887
G
R
G
G
G
F
F
S
G
L
G
G
K
P
S
Site 310
S1894
S
G
L
G
G
K
P
S
Q
D
A
A
N
K
N
Site 311
S1904
A
A
N
K
N
P
F
S
S
A
S
G
G
F
G
Site 312
S1905
A
N
K
N
P
F
S
S
A
S
G
G
F
G
S
Site 313
S1907
K
N
P
F
S
S
A
S
G
G
F
G
S
T
A
Site 314
S1912
S
A
S
G
G
F
G
S
T
A
T
S
N
T
S
Site 315
T1915
G
G
F
G
S
T
A
T
S
N
T
S
N
L
F
Site 316
S1916
G
F
G
S
T
A
T
S
N
T
S
N
L
F
G
Site 317
S1919
S
T
A
T
S
N
T
S
N
L
F
G
N
S
G
Site 318
S1925
T
S
N
L
F
G
N
S
G
A
K
T
F
G
G
Site 319
T1929
F
G
N
S
G
A
K
T
F
G
G
F
A
S
S
Site 320
S1935
K
T
F
G
G
F
A
S
S
S
F
G
E
Q
K
Site 321
S1936
T
F
G
G
F
A
S
S
S
F
G
E
Q
K
P
Site 322
S1937
F
G
G
F
A
S
S
S
F
G
E
Q
K
P
T
Site 323
T1944
S
F
G
E
Q
K
P
T
G
T
F
S
S
G
G
Site 324
T1946
G
E
Q
K
P
T
G
T
F
S
S
G
G
G
S
Site 325
S1948
Q
K
P
T
G
T
F
S
S
G
G
G
S
V
A
Site 326
S1949
K
P
T
G
T
F
S
S
G
G
G
S
V
A
S
Site 327
S1953
T
F
S
S
G
G
G
S
V
A
S
Q
G
F
G
Site 328
S1956
S
G
G
G
S
V
A
S
Q
G
F
G
F
S
S
Site 329
S1962
A
S
Q
G
F
G
F
S
S
P
N
K
T
G
G
Site 330
S1963
S
Q
G
F
G
F
S
S
P
N
K
T
G
G
F
Site 331
T1967
G
F
S
S
P
N
K
T
G
G
F
G
A
A
P
Site 332
S1978
G
A
A
P
V
F
G
S
P
P
T
F
G
G
S
Site 333
T1981
P
V
F
G
S
P
P
T
F
G
G
S
P
G
F
Site 334
S1985
S
P
P
T
F
G
G
S
P
G
F
G
G
V
P
Site 335
S1996
G
G
V
P
A
F
G
S
A
P
A
F
T
S
P
Site 336
S2002
G
S
A
P
A
F
T
S
P
L
G
S
T
G
G
Site 337
S2028
A
G
G
F
G
F
G
S
S
S
N
T
T
S
F
Site 338
S2029
G
G
F
G
F
G
S
S
S
N
T
T
S
F
G
Site 339
S2030
G
F
G
F
G
S
S
S
N
T
T
S
F
G
T
Site 340
T2032
G
F
G
S
S
S
N
T
T
S
F
G
T
L
A
Site 341
T2033
F
G
S
S
S
N
T
T
S
F
G
T
L
A
S
Site 342
S2034
G
S
S
S
N
T
T
S
F
G
T
L
A
S
Q
Site 343
S2040
T
S
F
G
T
L
A
S
Q
N
A
P
T
F
G
Site 344
T2045
L
A
S
Q
N
A
P
T
F
G
S
L
S
Q
Q
Site 345
S2048
Q
N
A
P
T
F
G
S
L
S
Q
Q
T
S
G
Site 346
S2050
A
P
T
F
G
S
L
S
Q
Q
T
S
G
F
G
Site 347
S2054
G
S
L
S
Q
Q
T
S
G
F
G
T
Q
S
S
Site 348
T2058
Q
Q
T
S
G
F
G
T
Q
S
S
G
F
S
G
Site 349
S2060
T
S
G
F
G
T
Q
S
S
G
F
S
G
F
G
Site 350
S2061
S
G
F
G
T
Q
S
S
G
F
S
G
F
G
S
Site 351
S2064
G
T
Q
S
S
G
F
S
G
F
G
S
G
T
G
Site 352
S2074
G
S
G
T
G
G
F
S
F
G
S
N
N
S
S
Site 353
S2077
T
G
G
F
S
F
G
S
N
N
S
S
V
Q
G
Site 354
S2081
S
F
G
S
N
N
S
S
V
Q
G
F
G
G
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation