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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cyclin C1
Full Name:
Cylicin-1
Alias:
CYCL1
Type:
Protein-serine kinase regulatory subunit, activator, cyclin
Mass (Da):
74242
Number AA:
650
UniProt ID:
P35663
International Prot ID:
IPI00020039
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0043159
GO:0033150
Uniprot
OncoNet
Molecular Function:
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007275
GO:0007283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
L
K
V
N
I
R
T
Y
D
N
S
I
P
I
S
Site 2
S17
N
I
R
T
Y
D
N
S
I
P
I
S
E
S
S
Site 3
S21
Y
D
N
S
I
P
I
S
E
S
S
R
K
S
W
Site 4
S23
N
S
I
P
I
S
E
S
S
R
K
S
W
N
Q
Site 5
S24
S
I
P
I
S
E
S
S
R
K
S
W
N
Q
K
Site 6
S27
I
S
E
S
S
R
K
S
W
N
Q
K
H
F
A
Site 7
T36
N
Q
K
H
F
A
L
T
F
P
K
P
L
Q
R
Site 8
T45
P
K
P
L
Q
R
G
T
N
D
K
S
R
P
L
Site 9
S49
Q
R
G
T
N
D
K
S
R
P
L
K
S
Q
I
Site 10
S54
D
K
S
R
P
L
K
S
Q
I
T
V
T
R
H
Site 11
T57
R
P
L
K
S
Q
I
T
V
T
R
H
D
K
R
Site 12
Y91
I
L
Q
W
P
P
I
Y
T
A
A
R
E
Q
T
Site 13
T98
Y
T
A
A
R
E
Q
T
P
F
R
H
L
Y
T
Site 14
Y104
Q
T
P
F
R
H
L
Y
T
S
K
T
H
L
K
Site 15
S106
P
F
R
H
L
Y
T
S
K
T
H
L
K
K
A
Site 16
T108
R
H
L
Y
T
S
K
T
H
L
K
K
A
E
Y
Site 17
S118
K
K
A
E
Y
K
K
S
K
D
E
K
G
G
T
Site 18
T125
S
K
D
E
K
G
G
T
P
L
K
K
D
S
K
Site 19
S131
G
T
P
L
K
K
D
S
K
K
K
G
G
S
Y
Site 20
S144
S
Y
A
T
N
P
E
S
K
Q
I
V
E
E
K
Site 21
T152
K
Q
I
V
E
E
K
T
K
R
Q
N
E
A
D
Site 22
T161
R
Q
N
E
A
D
K
T
P
L
K
S
S
H
E
Site 23
S165
A
D
K
T
P
L
K
S
S
H
E
N
E
Q
S
Site 24
S166
D
K
T
P
L
K
S
S
H
E
N
E
Q
S
K
Site 25
S172
S
S
H
E
N
E
Q
S
K
K
S
K
S
S
S
Site 26
S175
E
N
E
Q
S
K
K
S
K
S
S
S
E
T
N
Site 27
S177
E
Q
S
K
K
S
K
S
S
S
E
T
N
P
E
Site 28
S179
S
K
K
S
K
S
S
S
E
T
N
P
E
S
Q
Site 29
T181
K
S
K
S
S
S
E
T
N
P
E
S
Q
N
S
Site 30
S185
S
S
E
T
N
P
E
S
Q
N
S
K
T
V
S
Site 31
S188
T
N
P
E
S
Q
N
S
K
T
V
S
K
N
C
Site 32
T190
P
E
S
Q
N
S
K
T
V
S
K
N
C
S
Q
Site 33
S192
S
Q
N
S
K
T
V
S
K
N
C
S
Q
K
D
Site 34
S196
K
T
V
S
K
N
C
S
Q
K
D
K
K
D
S
Site 35
S203
S
Q
K
D
K
K
D
S
K
N
S
K
K
T
N
Site 36
T209
D
S
K
N
S
K
K
T
N
T
E
F
L
H
T
Site 37
T216
T
N
T
E
F
L
H
T
K
N
N
P
K
K
D
Site 38
T229
K
D
L
K
R
S
K
T
S
N
D
P
I
S
E
Site 39
S235
K
T
S
N
D
P
I
S
E
I
C
S
E
N
S
Site 40
S239
D
P
I
S
E
I
C
S
E
N
S
L
N
V
D
Site 41
S258
V
G
Q
S
D
D
E
S
I
N
F
D
A
W
L
Site 42
Y268
F
D
A
W
L
R
N
Y
S
Q
N
N
S
K
N
Site 43
S273
R
N
Y
S
Q
N
N
S
K
N
Y
S
L
K
Y
Site 44
S277
Q
N
N
S
K
N
Y
S
L
K
Y
T
K
Y
T
Site 45
Y280
S
K
N
Y
S
L
K
Y
T
K
Y
T
K
K
D
Site 46
T281
K
N
Y
S
L
K
Y
T
K
Y
T
K
K
D
T
Site 47
Y283
Y
S
L
K
Y
T
K
Y
T
K
K
D
T
K
K
Site 48
S295
T
K
K
N
A
K
K
S
S
D
A
E
S
E
D
Site 49
S296
K
K
N
A
K
K
S
S
D
A
E
S
E
D
S
Site 50
S300
K
K
S
S
D
A
E
S
E
D
S
K
D
A
K
Site 51
S303
S
D
A
E
S
E
D
S
K
D
A
K
K
D
S
Site 52
S310
S
K
D
A
K
K
D
S
K
K
V
K
K
N
V
Site 53
T330
K
K
D
V
K
K
D
T
E
S
T
D
A
E
S
Site 54
S332
D
V
K
K
D
T
E
S
T
D
A
E
S
G
D
Site 55
S337
T
E
S
T
D
A
E
S
G
D
S
K
D
E
R
Site 56
S340
T
D
A
E
S
G
D
S
K
D
E
R
K
D
T
Site 57
T347
S
K
D
E
R
K
D
T
K
K
D
K
K
K
L
Site 58
Y366
K
K
K
D
T
K
K
Y
P
E
S
T
D
T
E
Site 59
S369
D
T
K
K
Y
P
E
S
T
D
T
E
S
G
D
Site 60
T370
T
K
K
Y
P
E
S
T
D
T
E
S
G
D
A
Site 61
T372
K
Y
P
E
S
T
D
T
E
S
G
D
A
K
D
Site 62
S374
P
E
S
T
D
T
E
S
G
D
A
K
D
A
R
Site 63
S384
A
K
D
A
R
N
D
S
R
N
L
K
K
A
S
Site 64
T404
K
K
D
A
K
K
I
T
F
S
T
D
S
E
S
Site 65
S406
D
A
K
K
I
T
F
S
T
D
S
E
S
E
L
Site 66
T407
A
K
K
I
T
F
S
T
D
S
E
S
E
L
E
Site 67
S409
K
I
T
F
S
T
D
S
E
S
E
L
E
S
K
Site 68
S411
T
F
S
T
D
S
E
S
E
L
E
S
K
E
S
Site 69
S415
D
S
E
S
E
L
E
S
K
E
S
Q
K
D
E
Site 70
S418
S
E
L
E
S
K
E
S
Q
K
D
E
K
K
D
Site 71
S429
E
K
K
D
K
K
D
S
K
T
D
N
K
K
S
Site 72
T431
K
D
K
K
D
S
K
T
D
N
K
K
S
V
K
Site 73
S436
S
K
T
D
N
K
K
S
V
K
N
D
E
E
S
Site 74
S443
S
V
K
N
D
E
E
S
T
D
A
D
S
E
P
Site 75
S448
E
E
S
T
D
A
D
S
E
P
K
G
D
S
K
Site 76
S468
E
K
K
G
K
K
D
S
K
K
D
D
K
K
K
Site 77
S483
D
A
K
K
N
A
E
S
T
E
M
E
S
D
L
Site 78
S499
L
K
K
D
K
K
H
S
K
E
K
K
G
S
K
Site 79
T517
K
K
D
A
R
K
D
T
E
S
T
D
A
E
F
Site 80
S519
D
A
R
K
D
T
E
S
T
D
A
E
F
D
E
Site 81
S527
T
D
A
E
F
D
E
S
S
K
T
G
F
K
T
Site 82
S528
D
A
E
F
D
E
S
S
K
T
G
F
K
T
S
Site 83
T530
E
F
D
E
S
S
K
T
G
F
K
T
S
T
K
Site 84
S535
S
K
T
G
F
K
T
S
T
K
I
K
G
S
D
Site 85
S541
T
S
T
K
I
K
G
S
D
T
E
S
E
E
S
Site 86
T543
T
K
I
K
G
S
D
T
E
S
E
E
S
L
Y
Site 87
S545
I
K
G
S
D
T
E
S
E
E
S
L
Y
K
P
Site 88
S548
S
D
T
E
S
E
E
S
L
Y
K
P
G
A
K
Site 89
Y550
T
E
S
E
E
S
L
Y
K
P
G
A
K
K
K
Site 90
S561
A
K
K
K
I
D
E
S
D
G
T
S
A
N
S
Site 91
T564
K
I
D
E
S
D
G
T
S
A
N
S
K
M
E
Site 92
S565
I
D
E
S
D
G
T
S
A
N
S
K
M
E
G
Site 93
S568
S
D
G
T
S
A
N
S
K
M
E
G
L
E
S
Site 94
S575
S
K
M
E
G
L
E
S
K
R
G
F
R
M
S
Site 95
S582
S
K
R
G
F
R
M
S
S
K
K
T
T
F
N
Site 96
S583
K
R
G
F
R
M
S
S
K
K
T
T
F
N
E
Site 97
T587
R
M
S
S
K
K
T
T
F
N
E
K
G
E
K
Site 98
S596
N
E
K
G
E
K
A
S
T
G
R
V
P
P
S
Site 99
T597
E
K
G
E
K
A
S
T
G
R
V
P
P
S
R
Site 100
S603
S
T
G
R
V
P
P
S
R
E
K
P
P
L
P
Site 101
S615
P
L
P
A
C
E
P
S
L
P
S
P
K
V
R
Site 102
S618
A
C
E
P
S
L
P
S
P
K
V
R
R
L
C
Site 103
Y638
P
P
P
P
K
P
R
Y
A
P
L
P
E
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation