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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATP7B
Full Name:
Copper-transporting ATPase 2
Alias:
AT7B; ATPase, Cu++ transporting, beta polypeptide; Copper pump 2; EC 3.6.3.4; PWD; WC1; Wilson disease; Wilson disease-associated protein; WND
Type:
Vesicle protein; Hydrolase; Transporter; Membrane protein, integral; EC 3.6.3.4
Mass (Da):
157334
Number AA:
1465
UniProt ID:
P35670
International Prot ID:
IPI00020058
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005770
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005507
GO:0004008
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0006878
GO:0015677
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
P
E
Q
E
R
Q
I
T
A
R
E
G
A
S
R
Site 2
S20
G
A
S
R
K
I
L
S
K
L
S
L
P
T
R
Site 3
S54
G
L
D
G
L
G
P
S
S
Q
V
A
T
S
T
Site 4
S75
T
C
Q
S
C
V
K
S
I
E
D
R
I
S
N
Site 5
S81
K
S
I
E
D
R
I
S
N
L
K
G
I
I
S
Site 6
S88
S
N
L
K
G
I
I
S
M
K
V
S
L
E
Q
Site 7
T99
S
L
E
Q
G
S
A
T
V
K
Y
V
P
S
V
Site 8
S124
G
D
M
G
F
E
A
S
I
A
E
G
K
A
A
Site 9
S132
I
A
E
G
K
A
A
S
W
P
S
R
S
L
P
Site 10
S137
A
A
S
W
P
S
R
S
L
P
A
Q
E
A
V
Site 11
T153
K
L
R
V
E
G
M
T
C
Q
S
C
V
S
S
Site 12
S160
T
C
Q
S
C
V
S
S
I
E
G
K
V
R
K
Site 13
T186
S
N
Q
E
A
V
I
T
Y
Q
P
Y
L
I
Q
Site 14
S229
I
D
I
E
R
L
Q
S
T
N
P
K
R
P
L
Site 15
T230
D
I
E
R
L
Q
S
T
N
P
K
R
P
L
S
Site 16
S237
T
N
P
K
R
P
L
S
S
A
N
Q
N
F
N
Site 17
S246
A
N
Q
N
F
N
N
S
E
T
L
G
H
Q
G
Site 18
S254
E
T
L
G
H
Q
G
S
H
V
V
T
L
Q
L
Site 19
T258
H
Q
G
S
H
V
V
T
L
Q
L
R
I
D
G
Site 20
S291
G
V
Q
S
I
Q
V
S
L
E
N
K
T
A
Q
Site 21
Y301
N
K
T
A
Q
V
K
Y
D
P
S
C
T
S
P
Site 22
S304
A
Q
V
K
Y
D
P
S
C
T
S
P
V
A
L
Site 23
S307
K
Y
D
P
S
C
T
S
P
V
A
L
Q
R
A
Site 24
S326
P
P
G
N
F
K
V
S
L
P
D
G
A
E
G
Site 25
S334
L
P
D
G
A
E
G
S
G
T
D
H
R
S
S
Site 26
T336
D
G
A
E
G
S
G
T
D
H
R
S
S
S
S
Site 27
S340
G
S
G
T
D
H
R
S
S
S
S
H
S
P
G
Site 28
S341
S
G
T
D
H
R
S
S
S
S
H
S
P
G
S
Site 29
S342
G
T
D
H
R
S
S
S
S
H
S
P
G
S
P
Site 30
S343
T
D
H
R
S
S
S
S
H
S
P
G
S
P
P
Site 31
S345
H
R
S
S
S
S
H
S
P
G
S
P
P
R
N
Site 32
S348
S
S
S
H
S
P
G
S
P
P
R
N
Q
V
Q
Site 33
S382
H
S
I
E
G
M
I
S
Q
L
E
G
V
Q
Q
Site 34
S409
L
Y
N
P
S
V
I
S
P
E
E
L
R
A
A
Site 35
S425
E
D
M
G
F
E
A
S
V
V
S
E
S
C
S
Site 36
S428
G
F
E
A
S
V
V
S
E
S
C
S
T
N
P
Site 37
S430
E
A
S
V
V
S
E
S
C
S
T
N
P
L
G
Site 38
S432
S
V
V
S
E
S
C
S
T
N
P
L
G
N
H
Site 39
T433
V
V
S
E
S
C
S
T
N
P
L
G
N
H
S
Site 40
S440
T
N
P
L
G
N
H
S
A
G
N
S
M
V
Q
Site 41
S444
G
N
H
S
A
G
N
S
M
V
Q
T
T
D
G
Site 42
T448
A
G
N
S
M
V
Q
T
T
D
G
T
P
T
S
Site 43
T452
M
V
Q
T
T
D
G
T
P
T
S
V
Q
E
V
Site 44
S455
T
T
D
G
T
P
T
S
V
Q
E
V
A
P
H
Site 45
T463
V
Q
E
V
A
P
H
T
G
R
L
P
A
N
H
Site 46
S478
A
P
D
I
L
A
K
S
P
Q
S
T
R
A
V
Site 47
S481
I
L
A
K
S
P
Q
S
T
R
A
V
A
P
Q
Site 48
T482
L
A
K
S
P
Q
S
T
R
A
V
A
P
Q
K
Site 49
Y532
A
G
K
A
E
I
K
Y
D
P
E
V
I
Q
P
Site 50
Y559
E
A
A
V
M
E
D
Y
A
G
S
D
G
N
I
Site 51
T587
H
N
I
E
S
K
L
T
R
T
N
G
I
T
Y
Site 52
S630
E
E
I
G
F
H
A
S
L
A
Q
R
N
P
N
Site 53
S681
P
S
N
E
P
H
Q
S
M
V
L
D
H
N
I
Site 54
S721
F
Y
V
Q
A
Y
K
S
L
R
H
R
S
A
N
Site 55
S726
Y
K
S
L
R
H
R
S
A
N
M
D
V
L
I
Site 56
S759
V
A
E
K
A
E
R
S
P
V
T
F
F
D
T
Site 57
T762
K
A
E
R
S
P
V
T
F
F
D
T
P
P
M
Site 58
S786
W
L
E
H
L
A
K
S
K
T
S
E
A
L
A
Site 59
T788
E
H
L
A
K
S
K
T
S
E
A
L
A
K
L
Site 60
T865
T
G
E
A
M
P
V
T
K
K
P
G
S
T
V
Site 61
S876
G
S
T
V
I
A
G
S
I
N
A
H
G
S
V
Site 62
S909
L
V
E
E
A
Q
M
S
K
A
P
I
Q
Q
L
Site 63
T933
P
F
I
I
I
M
S
T
L
T
L
V
V
W
I
Site 64
Y953
D
F
G
V
V
Q
R
Y
F
P
N
P
N
K
H
Site 65
S962
P
N
P
N
K
H
I
S
Q
T
E
V
I
I
R
Site 66
T1023
E
M
A
H
K
I
K
T
V
M
F
D
K
T
G
Site 67
T1029
K
T
V
M
F
D
K
T
G
T
I
T
H
G
V
Site 68
T1050
L
L
L
G
D
V
A
T
L
P
L
R
K
V
L
Site 69
T1076
H
P
L
G
V
A
V
T
K
Y
C
K
E
E
L
Site 70
Y1078
L
G
V
A
V
T
K
Y
C
K
E
E
L
G
T
Site 71
T1085
Y
C
K
E
E
L
G
T
E
T
L
G
Y
C
T
Site 72
S1116
V
E
G
I
L
A
H
S
E
R
P
L
S
A
P
Site 73
S1121
A
H
S
E
R
P
L
S
A
P
A
S
H
L
N
Site 74
S1125
R
P
L
S
A
P
A
S
H
L
N
E
A
G
S
Site 75
S1132
S
H
L
N
E
A
G
S
L
P
A
E
K
D
A
Site 76
T1143
E
K
D
A
V
P
Q
T
F
S
V
L
I
G
N
Site 77
T1160
W
L
R
R
N
G
L
T
I
S
S
D
V
S
D
Site 78
S1162
R
R
N
G
L
T
I
S
S
D
V
S
D
A
M
Site 79
S1166
L
T
I
S
S
D
V
S
D
A
M
T
D
H
E
Site 80
T1170
S
D
V
S
D
A
M
T
D
H
E
M
K
G
Q
Site 81
T1226
I
T
G
D
N
R
K
T
A
R
A
I
A
T
Q
Site 82
S1272
V
G
D
G
V
N
D
S
P
A
L
A
Q
A
D
Site 83
T1317
S
I
H
L
S
K
R
T
V
R
R
I
R
I
N
Site 84
S1363
S
A
A
M
A
A
S
S
V
S
V
V
L
S
S
Site 85
Y1376
S
S
L
Q
L
K
C
Y
K
K
P
D
L
E
R
Site 86
Y1384
K
K
P
D
L
E
R
Y
E
A
Q
A
H
G
H
Site 87
T1396
H
G
H
M
K
P
L
T
A
S
Q
V
S
V
H
Site 88
S1401
P
L
T
A
S
Q
V
S
V
H
I
G
M
D
D
Site 89
S1413
M
D
D
R
W
R
D
S
P
R
A
T
P
W
D
Site 90
T1417
W
R
D
S
P
R
A
T
P
W
D
Q
V
S
Y
Site 91
S1423
A
T
P
W
D
Q
V
S
Y
V
S
Q
V
S
L
Site 92
Y1424
T
P
W
D
Q
V
S
Y
V
S
Q
V
S
L
S
Site 93
S1426
W
D
Q
V
S
Y
V
S
Q
V
S
L
S
S
L
Site 94
S1431
Y
V
S
Q
V
S
L
S
S
L
T
S
D
K
P
Site 95
S1432
V
S
Q
V
S
L
S
S
L
T
S
D
K
P
S
Site 96
S1435
V
S
L
S
S
L
T
S
D
K
P
S
R
H
S
Site 97
S1439
S
L
T
S
D
K
P
S
R
H
S
A
A
A
D
Site 98
S1442
S
D
K
P
S
R
H
S
A
A
A
D
D
D
G
Site 99
S1453
D
D
D
G
D
K
W
S
L
L
L
N
G
R
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation