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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TCF7
Full Name:
Transcription factor 7
Alias:
T-cell-specific transcription factor 1
Type:
Mass (Da):
41642
Number AA:
384
UniProt ID:
P36402
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
P
Q
L
D
S
G
G
G
G
A
G
G
Site 2
S37
G
E
E
Q
D
D
K
S
R
D
S
A
A
G
P
Site 3
S40
Q
D
D
K
S
R
D
S
A
A
G
P
E
R
D
Site 4
S53
R
D
L
A
E
L
K
S
S
L
V
N
E
S
E
Site 5
S54
D
L
A
E
L
K
S
S
L
V
N
E
S
E
G
Site 6
Y117
P
E
C
T
S
G
M
Y
K
E
T
V
Y
S
A
Site 7
T120
T
S
G
M
Y
K
E
T
V
Y
S
A
F
N
L
Site 8
S135
L
M
H
Y
P
P
P
S
G
A
G
Q
H
P
Q
Site 9
S161
P
H
G
V
P
Q
L
S
L
Y
E
H
F
N
S
Site 10
Y163
G
V
P
Q
L
S
L
Y
E
H
F
N
S
P
H
Site 11
S168
S
L
Y
E
H
F
N
S
P
H
P
T
P
A
P
Site 12
T172
H
F
N
S
P
H
P
T
P
A
P
A
D
I
S
Site 13
S179
T
P
A
P
A
D
I
S
Q
K
Q
V
H
R
P
Site 14
T189
Q
V
H
R
P
L
Q
T
P
D
L
S
G
F
Y
Site 15
S193
P
L
Q
T
P
D
L
S
G
F
Y
S
L
T
S
Site 16
Y196
T
P
D
L
S
G
F
Y
S
L
T
S
G
S
M
Site 17
S197
P
D
L
S
G
F
Y
S
L
T
S
G
S
M
G
Site 18
S200
S
G
F
Y
S
L
T
S
G
S
M
G
Q
L
P
Site 19
S202
F
Y
S
L
T
S
G
S
M
G
Q
L
P
H
T
Site 20
T209
S
M
G
Q
L
P
H
T
V
S
W
F
T
H
P
Site 21
S211
G
Q
L
P
H
T
V
S
W
F
T
H
P
S
L
Site 22
T214
P
H
T
V
S
W
F
T
H
P
S
L
M
L
G
Site 23
S222
H
P
S
L
M
L
G
S
G
V
P
G
H
P
A
Site 24
S240
H
P
A
I
V
P
P
S
G
K
Q
E
L
Q
P
Site 25
T254
P
F
D
R
N
L
K
T
Q
A
E
S
K
A
E
Site 26
Y279
P
L
N
A
F
M
L
Y
M
K
E
M
R
A
K
Site 27
S311
G
R
R
W
H
A
L
S
R
E
E
Q
A
K
Y
Site 28
Y318
S
R
E
E
Q
A
K
Y
Y
E
L
A
R
K
E
Site 29
Y319
R
E
E
Q
A
K
Y
Y
E
L
A
R
K
E
R
Site 30
Y333
R
Q
L
H
M
Q
L
Y
P
G
W
S
A
R
D
Site 31
Y342
G
W
S
A
R
D
N
Y
G
K
K
K
R
R
S
Site 32
S349
Y
G
K
K
K
R
R
S
R
E
K
H
Q
E
S
Site 33
T360
H
Q
E
S
T
T
E
T
N
W
P
R
E
L
K
Site 34
S374
K
D
G
N
G
Q
E
S
L
S
M
S
S
S
S
Site 35
S376
G
N
G
Q
E
S
L
S
M
S
S
S
S
S
P
Site 36
S378
G
Q
E
S
L
S
M
S
S
S
S
S
P
A
_
Site 37
S380
E
S
L
S
M
S
S
S
S
S
P
A
_
_
_
Site 38
S381
S
L
S
M
S
S
S
S
S
P
A
_
_
_
_
Site 39
S382
L
S
M
S
S
S
S
S
P
A
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation