KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LONP1
Full Name:
Lon protease homolog, mitochondrial
Alias:
LON; Lon peptidase 1, mitochondrial; Lon protease homolog, mitochondrial; Lon protease-like protein; LONHs; LONM; LONP; PIM1
Type:
Protease; EC 3.4.21.-
Mass (Da):
106489
Number AA:
959
UniProt ID:
P36776
International Prot ID:
IPI00005158
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042645
Uniprot
OncoNet
Molecular Function:
GO:0043531
GO:0005524
GO:0004176
PhosphoSite+
KinaseNET
Biological Process:
GO:0034599
GO:0032042
GO:0070407
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
A
A
S
T
G
Y
V
R
L
W
G
Site 2
Y7
_
M
A
A
S
T
G
Y
V
R
L
W
G
A
A
Site 3
T33
A
A
G
G
R
V
P
T
A
A
G
A
W
L
L
Site 4
T45
W
L
L
R
G
Q
R
T
C
D
A
S
P
P
W
Site 5
S49
G
Q
R
T
C
D
A
S
P
P
W
A
L
W
G
Site 6
S72
W
R
G
F
W
E
A
S
S
R
G
G
G
A
F
Site 7
S73
R
G
F
W
E
A
S
S
R
G
G
G
A
F
S
Site 8
S80
S
R
G
G
G
A
F
S
G
G
E
D
A
S
E
Site 9
S86
F
S
G
G
E
D
A
S
E
G
G
A
E
E
G
Site 10
S173
V
F
L
K
R
D
D
S
N
E
S
D
V
V
E
Site 11
S176
K
R
D
D
S
N
E
S
D
V
V
E
S
L
D
Site 12
S181
N
E
S
D
V
V
E
S
L
D
E
I
Y
H
T
Site 13
Y186
V
E
S
L
D
E
I
Y
H
T
G
T
F
A
Q
Site 14
T188
S
L
D
E
I
Y
H
T
G
T
F
A
Q
I
H
Site 15
S217
G
H
R
R
V
H
I
S
R
Q
L
E
V
E
P
Site 16
S239
K
H
K
P
R
R
K
S
K
R
G
K
K
E
A
Site 17
S251
K
E
A
E
D
E
L
S
A
R
H
P
A
E
L
Site 18
T263
A
E
L
A
M
E
P
T
P
E
L
P
A
E
V
Site 19
S313
L
N
P
L
Y
R
E
S
V
L
Q
M
M
Q
A
Site 20
T339
S
D
M
G
A
A
L
T
G
A
E
S
H
E
L
Site 21
T353
L
Q
D
V
L
E
E
T
N
I
P
K
R
L
Y
Site 22
Y360
T
N
I
P
K
R
L
Y
K
A
L
S
L
L
K
Site 23
S364
K
R
L
Y
K
A
L
S
L
L
K
K
E
F
E
Site 24
S373
L
K
K
E
F
E
L
S
K
L
Q
Q
R
L
G
Site 25
T390
V
E
E
K
I
K
Q
T
H
R
K
Y
L
L
Q
Site 26
Y394
I
K
Q
T
H
R
K
Y
L
L
Q
E
Q
L
K
Site 27
S452
L
G
L
L
D
N
H
S
S
E
F
N
V
T
R
Site 28
S453
G
L
L
D
N
H
S
S
E
F
N
V
T
R
N
Site 29
Y461
E
F
N
V
T
R
N
Y
L
D
W
L
T
S
I
Site 30
Y492
A
V
L
E
E
D
H
Y
G
M
E
D
V
K
K
Site 31
S513
A
V
S
Q
L
R
G
S
T
Q
G
K
I
L
C
Site 32
Y522
Q
G
K
I
L
C
F
Y
G
P
P
G
V
G
K
Site 33
S531
P
P
G
V
G
K
T
S
I
A
R
S
I
A
R
Site 34
S535
G
K
T
S
I
A
R
S
I
A
R
A
L
N
R
Site 35
Y544
A
R
A
L
N
R
E
Y
F
R
F
S
V
G
G
Site 36
S548
N
R
E
Y
F
R
F
S
V
G
G
M
T
D
V
Site 37
T564
E
I
K
G
H
R
R
T
Y
V
G
A
M
P
G
Site 38
Y565
I
K
G
H
R
R
T
Y
V
G
A
M
P
G
K
Site 39
T582
Q
C
L
K
K
T
K
T
E
N
P
L
I
L
I
Site 40
Y599
V
D
K
I
G
R
G
Y
Q
G
D
P
S
S
A
Site 41
S604
R
G
Y
Q
G
D
P
S
S
A
L
L
E
L
L
Site 42
S605
G
Y
Q
G
D
P
S
S
A
L
L
E
L
L
D
Site 43
S687
A
L
C
G
L
D
E
S
K
A
K
L
S
S
D
Site 44
Y703
L
T
L
L
I
K
Q
Y
C
R
E
S
G
V
R
Site 45
S707
I
K
Q
Y
C
R
E
S
G
V
R
N
L
Q
K
Site 46
S723
V
E
K
V
L
R
K
S
A
Y
K
I
V
S
G
Site 47
Y725
K
V
L
R
K
S
A
Y
K
I
V
S
G
E
A
Site 48
S729
K
S
A
Y
K
I
V
S
G
E
A
E
S
V
E
Site 49
S734
I
V
S
G
E
A
E
S
V
E
V
T
P
E
N
Site 50
T738
E
A
E
S
V
E
V
T
P
E
N
L
Q
D
F
Site 51
S783
S
T
L
F
V
E
T
S
L
R
R
P
Q
D
K
Site 52
S799
A
K
G
D
K
D
G
S
L
E
V
T
G
Q
L
Site 53
T803
K
D
G
S
L
E
V
T
G
Q
L
G
E
V
M
Site 54
Y834
Q
H
A
P
A
N
D
Y
L
V
T
S
H
I
H
Site 55
T849
L
H
V
P
E
G
A
T
P
K
D
G
P
S
A
Site 56
T880
V
R
Q
N
L
A
M
T
G
E
V
S
L
T
G
Site 57
T899
V
G
G
I
K
E
K
T
I
A
A
K
R
A
G
Site 58
Y921
A
E
N
K
K
D
F
Y
D
L
A
A
F
I
T
Site 59
Y939
E
V
H
F
V
E
H
Y
R
E
I
F
D
I
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation