KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HSD17B2
Full Name:
Estradiol 17-beta-dehydrogenase 2
Alias:
17-beta-HSD 2; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; DHB2; E2DH; EDH17B2; HSD17; Hydroxysteroid (17-beta) dehydrogenase 2; Microsomal 17-beta-hydroxysteroid dehydrogenase; SDR9C2; Short chain dehydrogenase/reductase family 9C, member 2
Type:
EC 1.1.1.62; Lipid Metabolism - androgen and estrogen; EC 1.1.1.63; Oxidoreductase; Endoplasmic reticulum
Mass (Da):
42785
Number AA:
387
UniProt ID:
P37059
International Prot ID:
IPI00019872
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0047006
GO:0005488
GO:0004303
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0032526
GO:0006694
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y27
C
G
T
V
F
C
K
Y
K
K
S
S
G
Q
L
Site 2
T127
G
A
E
E
L
R
R
T
C
S
P
R
L
S
V
Site 3
S129
E
E
L
R
R
T
C
S
P
R
L
S
V
L
Q
Site 4
S133
R
T
C
S
P
R
L
S
V
L
Q
M
D
I
T
Site 5
T140
S
V
L
Q
M
D
I
T
K
P
V
Q
I
K
D
Site 6
T183
D
G
E
L
L
L
M
T
D
Y
K
Q
C
M
A
Site 7
S218
K
G
R
L
V
N
V
S
S
M
G
G
G
A
P
Site 8
S231
A
P
M
E
R
L
A
S
Y
G
S
S
K
A
A
Site 9
Y232
P
M
E
R
L
A
S
Y
G
S
S
K
A
A
V
Site 10
S251
S
V
M
R
L
E
L
S
K
W
G
I
K
V
A
Site 11
S259
K
W
G
I
K
V
A
S
I
Q
P
G
G
F
L
Site 12
T267
I
Q
P
G
G
F
L
T
N
I
A
G
T
S
D
Site 13
S273
L
T
N
I
A
G
T
S
D
K
W
E
K
L
E
Site 14
Y295
P
A
E
V
Q
E
D
Y
G
Q
D
Y
I
L
A
Site 15
Y299
Q
E
D
Y
G
Q
D
Y
I
L
A
Q
R
N
F
Site 16
S319
S
L
A
S
K
D
F
S
P
V
L
R
D
I
Q
Site 17
S333
Q
H
A
I
L
A
K
S
P
F
A
Y
Y
T
P
Site 18
Y337
L
A
K
S
P
F
A
Y
Y
T
P
G
K
G
A
Site 19
Y338
A
K
S
P
F
A
Y
Y
T
P
G
K
G
A
Y
Site 20
T339
K
S
P
F
A
Y
Y
T
P
G
K
G
A
Y
L
Site 21
Y353
L
W
I
C
L
A
H
Y
L
P
I
G
I
Y
D
Site 22
Y359
H
Y
L
P
I
G
I
Y
D
Y
F
A
K
R
H
Site 23
Y361
L
P
I
G
I
Y
D
Y
F
A
K
R
H
F
G
Site 24
Y382
R
A
L
R
M
P
N
Y
K
K
K
A
T
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation