PhosphoNET

           
Protein Info 
   
Short Name:  ENaC alpha
Full Name:  Amiloride-sensitive sodium channel subunit alpha
Alias:  Alpha-NaCH;Epithelial Na(+) channel subunit alpha;Nonvoltage-gated sodium channel 1 subunit alpha;SCNEA
Type:  Channel protein
Mass (Da):  75704
Number AA:  669
UniProt ID:  P37088
International Prot ID:  IPI00019931
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:  GO:0050699  GO:0031402   PhosphoSite+ KinaseNET
Biological Process:  GO:0007588  GO:0050896  GO:0050909 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S11NKLEEQDSSPPQSTP
Site 2S12KLEEQDSSPPQSTPG
Site 3S16QDSSPPQSTPGLMKG
Site 4T17DSSPPQSTPGLMKGN
Site 5S54ALIEFHRSYRELFEF
Site 6Y55LIEFHRSYRELFEFF
Site 7T154LEELDRITEQTLFDL
Site 8S174FTTLVAGSRSRRDLR
Site 9S376LRPGVETSISMRKET
Site 10S378PGVETSISMRKETLD
Site 11T383SISMRKETLDRLGGD
Site 12S590MLLRRFRSRYWSPGR
Site 13Y592LRRFRSRYWSPGRGG
Site 14S594RFRSRYWSPGRGGRG
Site 15S607RGAQEVASTLASSPP
Site 16T608GAQEVASTLASSPPS
Site 17S611EVASTLASSPPSHFC
Site 18S615TLASSPPSHFCPHPM
Site 19S623HFCPHPMSLSLSQPG
Site 20S625CPHPMSLSLSQPGPA
Site 21S627HPMSLSLSQPGPAPS
Site 22S634SQPGPAPSPALTAPP
Site 23T638PAPSPALTAPPPAYA
Site 24Y644LTAPPPAYATLGPRP
Site 25T646APPPAYATLGPRPSP
Site 26S652ATLGPRPSPGGSAGA
Site 27S656PRPSPGGSAGASSST
Site 28S660PGGSAGASSSTCPLG
Site 29S661GGSAGASSSTCPLGG
Site 30S662GSAGASSSTCPLGGP
Site 31T663SAGASSSTCPLGGP_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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