KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
BRCA1
Full Name:
Breast cancer type 1 susceptibility protein
Alias:
BRCA1/BRCA2-containing complex, subunit 1; BRCC1; Breast cancer 1, early onset; Familial breast/ovarian cancer gene 1; RING finger protein 53; RNF53
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Tumor suppressor
Mass (Da):
207721
Number AA:
1863
UniProt ID:
P38398
International Prot ID:
IPI00218982
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070531
GO:0031436
GO:0008274
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0050681
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0006978
GO:0008630
GO:0031572
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
E
L
I
K
E
P
V
S
T
K
C
D
H
I
F
Site 2
S59
L
N
Q
K
K
G
P
S
Q
C
P
L
C
K
N
Site 3
T69
P
L
C
K
N
D
I
T
K
R
S
L
Q
E
S
Site 4
S72
K
N
D
I
T
K
R
S
L
Q
E
S
T
R
F
Site 5
S76
T
K
R
S
L
Q
E
S
T
R
F
S
Q
L
V
Site 6
S80
L
Q
E
S
T
R
F
S
Q
L
V
E
E
L
L
Site 7
S104
T
G
L
E
Y
A
N
S
Y
N
F
A
K
K
E
Site 8
S114
F
A
K
K
E
N
N
S
P
E
H
L
K
D
E
Site 9
S123
E
H
L
K
D
E
V
S
I
I
Q
S
M
G
Y
Site 10
S127
D
E
V
S
I
I
Q
S
M
G
Y
R
N
R
A
Site 11
S140
R
A
K
R
L
L
Q
S
E
P
E
N
P
S
L
Site 12
S146
Q
S
E
P
E
N
P
S
L
Q
E
T
S
L
S
Site 13
T150
E
N
P
S
L
Q
E
T
S
L
S
V
Q
L
S
Site 14
S151
N
P
S
L
Q
E
T
S
L
S
V
Q
L
S
N
Site 15
S153
S
L
Q
E
T
S
L
S
V
Q
L
S
N
L
G
Site 16
T161
V
Q
L
S
N
L
G
T
V
R
T
L
R
T
K
Site 17
T164
S
N
L
G
T
V
R
T
L
R
T
K
Q
R
I
Site 18
S177
R
I
Q
P
Q
K
T
S
V
Y
I
E
L
G
S
Site 19
Y179
Q
P
Q
K
T
S
V
Y
I
E
L
G
S
D
S
Site 20
S184
S
V
Y
I
E
L
G
S
D
S
S
E
D
T
V
Site 21
S186
Y
I
E
L
G
S
D
S
S
E
D
T
V
N
K
Site 22
T190
G
S
D
S
S
E
D
T
V
N
K
A
T
Y
C
Site 23
Y196
D
T
V
N
K
A
T
Y
C
S
V
G
D
Q
E
Site 24
T208
D
Q
E
L
L
Q
I
T
P
Q
G
T
R
D
E
Site 25
S217
Q
G
T
R
D
E
I
S
L
D
S
A
K
K
A
Site 26
S229
K
K
A
A
C
E
F
S
E
T
D
V
T
N
T
Site 27
T231
A
A
C
E
F
S
E
T
D
V
T
N
T
E
H
Site 28
T234
E
F
S
E
T
D
V
T
N
T
E
H
H
Q
P
Site 29
Y261
A
E
R
H
P
E
K
Y
Q
G
S
S
V
S
N
Site 30
S264
H
P
E
K
Y
Q
G
S
S
V
S
N
L
H
V
Site 31
S265
P
E
K
Y
Q
G
S
S
V
S
N
L
H
V
E
Site 32
T276
L
H
V
E
P
C
G
T
N
T
H
A
S
S
L
Site 33
T278
V
E
P
C
G
T
N
T
H
A
S
S
L
Q
H
Site 34
S282
G
T
N
T
H
A
S
S
L
Q
H
E
N
S
S
Site 35
S288
S
S
L
Q
H
E
N
S
S
L
L
L
T
K
D
Site 36
T293
E
N
S
S
L
L
L
T
K
D
R
M
N
V
E
Site 37
S308
K
A
E
F
C
N
K
S
K
Q
P
G
L
A
R
Site 38
S316
K
Q
P
G
L
A
R
S
Q
H
N
R
W
A
G
Site 39
T333
E
T
C
N
D
R
R
T
P
S
T
E
K
K
V
Site 40
S335
C
N
D
R
R
T
P
S
T
E
K
K
V
D
L
Site 41
T336
N
D
R
R
T
P
S
T
E
K
K
V
D
L
N
Site 42
S361
N
K
Q
K
L
P
C
S
E
N
P
R
D
T
E
Site 43
T367
C
S
E
N
P
R
D
T
E
D
V
P
W
I
T
Site 44
T374
T
E
D
V
P
W
I
T
L
N
S
S
I
Q
K
Site 45
S387
Q
K
V
N
E
W
F
S
R
S
D
E
L
L
G
Site 46
S389
V
N
E
W
F
S
R
S
D
E
L
L
G
S
D
Site 47
S395
R
S
D
E
L
L
G
S
D
D
S
H
D
G
E
Site 48
S398
E
L
L
G
S
D
D
S
H
D
G
E
S
E
S
Site 49
S403
D
D
S
H
D
G
E
S
E
S
N
A
K
V
A
Site 50
S405
S
H
D
G
E
S
E
S
N
A
K
V
A
D
V
Site 51
Y422
V
L
N
E
V
D
E
Y
S
G
S
S
E
K
I
Site 52
S423
L
N
E
V
D
E
Y
S
G
S
S
E
K
I
D
Site 53
S425
E
V
D
E
Y
S
G
S
S
E
K
I
D
L
L
Site 54
S426
V
D
E
Y
S
G
S
S
E
K
I
D
L
L
A
Site 55
S434
E
K
I
D
L
L
A
S
D
P
H
E
A
L
I
Site 56
S444
H
E
A
L
I
C
K
S
E
R
V
H
S
K
S
Site 57
S449
C
K
S
E
R
V
H
S
K
S
V
E
S
N
I
Site 58
S451
S
E
R
V
H
S
K
S
V
E
S
N
I
E
D
Site 59
S454
V
H
S
K
S
V
E
S
N
I
E
D
K
I
F
Site 60
T464
E
D
K
I
F
G
K
T
Y
R
K
K
A
S
L
Site 61
S470
K
T
Y
R
K
K
A
S
L
P
N
L
S
H
V
Site 62
S475
K
A
S
L
P
N
L
S
H
V
T
E
N
L
I
Site 63
T499
I
I
Q
E
R
P
L
T
N
K
L
K
R
K
R
Site 64
T509
L
K
R
K
R
R
P
T
S
G
L
H
P
E
D
Site 65
S510
K
R
K
R
R
P
T
S
G
L
H
P
E
D
F
Site 66
T528
A
D
L
A
V
Q
K
T
P
E
M
I
N
Q
G
Site 67
T557
N
S
G
H
E
N
K
T
K
G
D
S
I
Q
N
Site 68
S573
K
N
P
N
P
I
E
S
L
E
K
E
S
A
F
Site 69
T582
E
K
E
S
A
F
K
T
K
A
E
P
I
S
S
Site 70
S588
K
T
K
A
E
P
I
S
S
S
I
S
N
M
E
Site 71
S589
T
K
A
E
P
I
S
S
S
I
S
N
M
E
L
Site 72
S590
K
A
E
P
I
S
S
S
I
S
N
M
E
L
E
Site 73
S592
E
P
I
S
S
S
I
S
N
M
E
L
E
L
N
Site 74
S603
L
E
L
N
I
H
N
S
K
A
P
K
K
N
R
Site 75
S615
K
N
R
L
R
R
K
S
S
T
R
H
I
H
A
Site 76
S616
N
R
L
R
R
K
S
S
T
R
H
I
H
A
L
Site 77
T617
R
L
R
R
K
S
S
T
R
H
I
H
A
L
E
Site 78
S628
H
A
L
E
L
V
V
S
R
N
L
S
P
P
N
Site 79
S632
L
V
V
S
R
N
L
S
P
P
N
C
T
E
L
Site 80
S643
C
T
E
L
Q
I
D
S
C
S
S
S
E
E
I
Site 81
S645
E
L
Q
I
D
S
C
S
S
S
E
E
I
K
K
Site 82
S647
Q
I
D
S
C
S
S
S
E
E
I
K
K
K
K
Site 83
Y655
E
E
I
K
K
K
K
Y
N
Q
M
P
V
R
H
Site 84
S663
N
Q
M
P
V
R
H
S
R
N
L
Q
L
M
E
Site 85
T676
M
E
G
K
E
P
A
T
G
A
K
K
S
N
K
Site 86
S681
P
A
T
G
A
K
K
S
N
K
P
N
E
Q
T
Site 87
S689
N
K
P
N
E
Q
T
S
K
R
H
D
S
D
T
Site 88
S694
Q
T
S
K
R
H
D
S
D
T
F
P
E
L
K
Site 89
T696
S
K
R
H
D
S
D
T
F
P
E
L
K
L
T
Site 90
T703
T
F
P
E
L
K
L
T
N
A
P
G
S
F
T
Site 91
S708
K
L
T
N
A
P
G
S
F
T
K
C
S
N
T
Site 92
S713
P
G
S
F
T
K
C
S
N
T
S
E
L
K
E
Site 93
S725
L
K
E
F
V
N
P
S
L
P
R
E
E
K
E
Site 94
T737
E
K
E
E
K
L
E
T
V
K
V
S
N
N
A
Site 95
S741
K
L
E
T
V
K
V
S
N
N
A
E
D
P
K
Site 96
S753
D
P
K
D
L
M
L
S
G
E
R
V
L
Q
T
Site 97
T760
S
G
E
R
V
L
Q
T
E
R
S
V
E
S
S
Site 98
S763
R
V
L
Q
T
E
R
S
V
E
S
S
S
I
S
Site 99
S766
Q
T
E
R
S
V
E
S
S
S
I
S
L
V
P
Site 100
S767
T
E
R
S
V
E
S
S
S
I
S
L
V
P
G
Site 101
S768
E
R
S
V
E
S
S
S
I
S
L
V
P
G
T
Site 102
S770
S
V
E
S
S
S
I
S
L
V
P
G
T
D
Y
Site 103
T775
S
I
S
L
V
P
G
T
D
Y
G
T
Q
E
S
Site 104
Y777
S
L
V
P
G
T
D
Y
G
T
Q
E
S
I
S
Site 105
T779
V
P
G
T
D
Y
G
T
Q
E
S
I
S
L
L
Site 106
S782
T
D
Y
G
T
Q
E
S
I
S
L
L
E
V
S
Site 107
T796
S
T
L
G
K
A
K
T
E
P
N
K
C
V
S
Site 108
S803
T
E
P
N
K
C
V
S
Q
C
A
A
F
E
N
Site 109
S819
K
G
L
I
H
G
C
S
K
D
N
R
N
D
T
Site 110
T826
S
K
D
N
R
N
D
T
E
G
F
K
Y
P
L
Site 111
Y831
N
D
T
E
G
F
K
Y
P
L
G
H
E
V
N
Site 112
S840
L
G
H
E
V
N
H
S
R
E
T
S
I
E
M
Site 113
T843
E
V
N
H
S
R
E
T
S
I
E
M
E
E
S
Site 114
S844
V
N
H
S
R
E
T
S
I
E
M
E
E
S
E
Site 115
S850
T
S
I
E
M
E
E
S
E
L
D
A
Q
Y
L
Site 116
Y856
E
S
E
L
D
A
Q
Y
L
Q
N
T
F
K
V
Site 117
T860
D
A
Q
Y
L
Q
N
T
F
K
V
S
K
R
Q
Site 118
S864
L
Q
N
T
F
K
V
S
K
R
Q
S
F
A
P
Site 119
S868
F
K
V
S
K
R
Q
S
F
A
P
F
S
N
P
Site 120
S873
R
Q
S
F
A
P
F
S
N
P
G
N
A
E
E
Site 121
T884
N
A
E
E
E
C
A
T
F
S
A
H
S
G
S
Site 122
S891
T
F
S
A
H
S
G
S
L
K
K
Q
S
P
K
Site 123
S896
S
G
S
L
K
K
Q
S
P
K
V
T
F
E
C
Site 124
T900
K
K
Q
S
P
K
V
T
F
E
C
E
Q
K
E
Site 125
S945
P
V
D
N
A
K
C
S
I
K
G
G
S
R
F
Site 126
S950
K
C
S
I
K
G
G
S
R
F
C
L
S
S
Q
Site 127
S955
G
G
S
R
F
C
L
S
S
Q
F
R
G
N
E
Site 128
S956
G
S
R
F
C
L
S
S
Q
F
R
G
N
E
T
Site 129
T967
G
N
E
T
G
L
I
T
P
N
K
H
G
L
L
Site 130
Y978
H
G
L
L
Q
N
P
Y
R
I
P
P
L
F
P
Site 131
S988
P
P
L
F
P
I
K
S
F
V
K
T
K
C
K
Site 132
T992
P
I
K
S
F
V
K
T
K
C
K
K
N
L
L
Site 133
S1007
E
E
N
F
E
E
H
S
M
S
P
E
R
E
M
Site 134
S1009
N
F
E
E
H
S
M
S
P
E
R
E
M
G
N
Site 135
S1021
M
G
N
E
N
I
P
S
T
V
S
T
I
S
R
Site 136
T1022
G
N
E
N
I
P
S
T
V
S
T
I
S
R
N
Site 137
S1024
E
N
I
P
S
T
V
S
T
I
S
R
N
N
I
Site 138
T1025
N
I
P
S
T
V
S
T
I
S
R
N
N
I
R
Site 139
S1042
V
F
K
E
A
S
S
S
N
I
N
E
V
G
S
Site 140
S1050
N
I
N
E
V
G
S
S
T
N
E
V
G
S
S
Site 141
T1051
I
N
E
V
G
S
S
T
N
E
V
G
S
S
I
Site 142
S1057
S
T
N
E
V
G
S
S
I
N
E
I
G
S
S
Site 143
S1063
S
S
I
N
E
I
G
S
S
D
E
N
I
Q
A
Site 144
S1064
S
I
N
E
I
G
S
S
D
E
N
I
Q
A
E
Site 145
Y1094
G
V
L
Q
P
E
V
Y
K
Q
S
L
P
G
S
Site 146
S1097
Q
P
E
V
Y
K
Q
S
L
P
G
S
N
C
K
Site 147
S1101
Y
K
Q
S
L
P
G
S
N
C
K
H
P
E
I
Site 148
Y1113
P
E
I
K
K
Q
E
Y
E
E
V
V
Q
T
V
Site 149
T1119
E
Y
E
E
V
V
Q
T
V
N
T
D
F
S
P
Site 150
S1125
Q
T
V
N
T
D
F
S
P
Y
L
I
S
D
N
Site 151
S1130
D
F
S
P
Y
L
I
S
D
N
L
E
Q
P
M
Site 152
S1140
L
E
Q
P
M
G
S
S
H
A
S
Q
V
C
S
Site 153
S1143
P
M
G
S
S
H
A
S
Q
V
C
S
E
T
P
Site 154
S1147
S
H
A
S
Q
V
C
S
E
T
P
D
D
L
L
Site 155
T1149
A
S
Q
V
C
S
E
T
P
D
D
L
L
D
D
Site 156
T1163
D
G
E
I
K
E
D
T
S
F
A
E
N
D
I
Site 157
S1164
G
E
I
K
E
D
T
S
F
A
E
N
D
I
K
Site 158
S1173
A
E
N
D
I
K
E
S
S
A
V
F
S
K
S
Site 159
S1174
E
N
D
I
K
E
S
S
A
V
F
S
K
S
V
Site 160
S1178
K
E
S
S
A
V
F
S
K
S
V
Q
K
G
E
Site 161
S1180
S
S
A
V
F
S
K
S
V
Q
K
G
E
L
S
Site 162
S1187
S
V
Q
K
G
E
L
S
R
S
P
S
P
F
T
Site 163
S1189
Q
K
G
E
L
S
R
S
P
S
P
F
T
H
T
Site 164
S1191
G
E
L
S
R
S
P
S
P
F
T
H
T
H
L
Site 165
T1194
S
R
S
P
S
P
F
T
H
T
H
L
A
Q
G
Site 166
T1196
S
P
S
P
F
T
H
T
H
L
A
Q
G
Y
R
Site 167
Y1202
H
T
H
L
A
Q
G
Y
R
R
G
A
K
K
L
Site 168
S1211
R
G
A
K
K
L
E
S
S
E
E
N
L
S
S
Site 169
S1212
G
A
K
K
L
E
S
S
E
E
N
L
S
S
E
Site 170
S1217
E
S
S
E
E
N
L
S
S
E
D
E
E
L
P
Site 171
S1218
S
S
E
E
N
L
S
S
E
D
E
E
L
P
C
Site 172
S1239
G
K
V
N
N
I
P
S
Q
S
T
R
H
S
T
Site 173
S1241
V
N
N
I
P
S
Q
S
T
R
H
S
T
V
A
Site 174
S1245
P
S
Q
S
T
R
H
S
T
V
A
T
E
C
L
Site 175
T1246
S
Q
S
T
R
H
S
T
V
A
T
E
C
L
S
Site 176
T1249
T
R
H
S
T
V
A
T
E
C
L
S
K
N
T
Site 177
S1262
N
T
E
E
N
L
L
S
L
K
N
S
L
N
D
Site 178
S1266
N
L
L
S
L
K
N
S
L
N
D
C
S
N
Q
Site 179
S1271
K
N
S
L
N
D
C
S
N
Q
V
I
L
A
K
Site 180
S1280
Q
V
I
L
A
K
A
S
Q
E
H
H
L
S
E
Site 181
S1286
A
S
Q
E
H
H
L
S
E
E
T
K
C
S
A
Site 182
S1292
L
S
E
E
T
K
C
S
A
S
L
F
S
S
Q
Site 183
S1294
E
E
T
K
C
S
A
S
L
F
S
S
Q
C
S
Site 184
S1297
K
C
S
A
S
L
F
S
S
Q
C
S
E
L
E
Site 185
S1298
C
S
A
S
L
F
S
S
Q
C
S
E
L
E
D
Site 186
S1301
S
L
F
S
S
Q
C
S
E
L
E
D
L
T
A
Site 187
T1307
C
S
E
L
E
D
L
T
A
N
T
N
T
Q
D
Site 188
T1312
D
L
T
A
N
T
N
T
Q
D
P
F
L
I
G
Site 189
S1328
S
K
Q
M
R
H
Q
S
E
S
Q
G
V
G
L
Site 190
S1330
Q
M
R
H
Q
S
E
S
Q
G
V
G
L
S
D
Site 191
S1336
E
S
Q
G
V
G
L
S
D
K
E
L
V
S
D
Site 192
S1342
L
S
D
K
E
L
V
S
D
D
E
E
R
G
T
Site 193
T1349
S
D
D
E
E
R
G
T
G
L
E
E
N
N
Q
Site 194
S1370
S
N
L
G
E
A
A
S
G
C
E
S
E
T
S
Site 195
S1374
E
A
A
S
G
C
E
S
E
T
S
V
S
E
D
Site 196
S1377
S
G
C
E
S
E
T
S
V
S
E
D
C
S
G
Site 197
S1379
C
E
S
E
T
S
V
S
E
D
C
S
G
L
S
Site 198
S1383
T
S
V
S
E
D
C
S
G
L
S
S
Q
S
D
Site 199
S1386
S
E
D
C
S
G
L
S
S
Q
S
D
I
L
T
Site 200
S1387
E
D
C
S
G
L
S
S
Q
S
D
I
L
T
T
Site 201
T1393
S
S
Q
S
D
I
L
T
T
Q
Q
R
D
T
M
Site 202
T1399
L
T
T
Q
Q
R
D
T
M
Q
H
N
L
I
K
Site 203
S1423
A
V
L
E
Q
H
G
S
Q
P
S
N
S
Y
P
Site 204
S1426
E
Q
H
G
S
Q
P
S
N
S
Y
P
S
I
I
Site 205
S1428
H
G
S
Q
P
S
N
S
Y
P
S
I
I
S
D
Site 206
Y1429
G
S
Q
P
S
N
S
Y
P
S
I
I
S
D
S
Site 207
S1431
Q
P
S
N
S
Y
P
S
I
I
S
D
S
S
A
Site 208
S1434
N
S
Y
P
S
I
I
S
D
S
S
A
L
E
D
Site 209
S1437
P
S
I
I
S
D
S
S
A
L
E
D
L
R
N
Site 210
S1448
D
L
R
N
P
E
Q
S
T
S
E
K
A
V
L
Site 211
S1450
R
N
P
E
Q
S
T
S
E
K
A
V
L
T
S
Site 212
T1456
T
S
E
K
A
V
L
T
S
Q
K
S
S
E
Y
Site 213
S1457
S
E
K
A
V
L
T
S
Q
K
S
S
E
Y
P
Site 214
S1460
A
V
L
T
S
Q
K
S
S
E
Y
P
I
S
Q
Site 215
S1461
V
L
T
S
Q
K
S
S
E
Y
P
I
S
Q
N
Site 216
Y1463
T
S
Q
K
S
S
E
Y
P
I
S
Q
N
P
E
Site 217
S1466
K
S
S
E
Y
P
I
S
Q
N
P
E
G
L
S
Site 218
S1473
S
Q
N
P
E
G
L
S
A
D
K
F
E
V
S
Site 219
S1480
S
A
D
K
F
E
V
S
A
D
S
S
T
S
K
Site 220
S1483
K
F
E
V
S
A
D
S
S
T
S
K
N
K
E
Site 221
S1484
F
E
V
S
A
D
S
S
T
S
K
N
K
E
P
Site 222
S1496
K
E
P
G
V
E
R
S
S
P
S
K
C
P
S
Site 223
S1497
E
P
G
V
E
R
S
S
P
S
K
C
P
S
L
Site 224
S1499
G
V
E
R
S
S
P
S
K
C
P
S
L
D
D
Site 225
S1503
S
S
P
S
K
C
P
S
L
D
D
R
W
Y
M
Site 226
Y1509
P
S
L
D
D
R
W
Y
M
H
S
C
S
G
S
Site 227
Y1522
G
S
L
Q
N
R
N
Y
P
S
Q
E
E
L
I
Site 228
S1524
L
Q
N
R
N
Y
P
S
Q
E
E
L
I
K
V
Site 229
S1542
E
E
Q
Q
L
E
E
S
G
P
H
D
L
T
E
Site 230
T1548
E
S
G
P
H
D
L
T
E
T
S
Y
L
P
R
Site 231
T1550
G
P
H
D
L
T
E
T
S
Y
L
P
R
Q
D
Site 232
Y1552
H
D
L
T
E
T
S
Y
L
P
R
Q
D
L
E
Site 233
T1561
P
R
Q
D
L
E
G
T
P
Y
L
E
S
G
I
Site 234
Y1563
Q
D
L
E
G
T
P
Y
L
E
S
G
I
S
L
Site 235
S1566
E
G
T
P
Y
L
E
S
G
I
S
L
F
S
D
Site 236
S1569
P
Y
L
E
S
G
I
S
L
F
S
D
D
P
E
Site 237
S1572
E
S
G
I
S
L
F
S
D
D
P
E
S
D
P
Site 238
S1577
L
F
S
D
D
P
E
S
D
P
S
E
D
R
A
Site 239
S1580
D
D
P
E
S
D
P
S
E
D
R
A
P
E
S
Site 240
S1587
S
E
D
R
A
P
E
S
A
R
V
G
N
I
P
Site 241
S1596
R
V
G
N
I
P
S
S
T
S
A
L
K
V
P
Site 242
S1598
G
N
I
P
S
S
T
S
A
L
K
V
P
Q
L
Site 243
S1610
P
Q
L
K
V
A
E
S
A
Q
S
P
A
A
A
Site 244
S1613
K
V
A
E
S
A
Q
S
P
A
A
A
H
T
T
Site 245
S1631
G
Y
N
A
M
E
E
S
V
S
R
E
K
P
E
Site 246
S1633
N
A
M
E
E
S
V
S
R
E
K
P
E
L
T
Site 247
S1642
E
K
P
E
L
T
A
S
T
E
R
V
N
K
R
Site 248
S1651
E
R
V
N
K
R
M
S
M
V
V
S
G
L
T
Site 249
S1655
K
R
M
S
M
V
V
S
G
L
T
P
E
E
F
Site 250
Y1666
P
E
E
F
M
L
V
Y
K
F
A
R
K
H
H
Site 251
T1675
F
A
R
K
H
H
I
T
L
T
N
L
I
T
E
Site 252
T1700
A
E
F
V
C
E
R
T
L
K
Y
F
L
G
I
Site 253
T1720
V
V
S
Y
F
W
V
T
Q
S
I
K
E
R
K
Site 254
S1755
G
P
K
R
A
R
E
S
Q
D
R
K
I
F
R
Site 255
Y1769
R
G
L
E
I
C
C
Y
G
P
F
T
N
M
P
Site 256
Y1853
Q
C
Q
E
L
D
T
Y
L
I
P
Q
I
P
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation