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Updated November 2019
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Protein Info
Short Name:
COL18A1
Full Name:
Collagen alpha-1(XVIII) chain
Alias:
Type:
Mass (Da):
178188
Number AA:
1754
UniProt ID:
P39060
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T43
E
D
T
S
H
A
A
T
T
I
P
E
P
Q
G
Site 2
T60
P
V
Q
P
T
A
D
T
T
T
H
V
T
P
R
Site 3
T61
V
Q
P
T
A
D
T
T
T
H
V
T
P
R
N
Site 4
T65
A
D
T
T
T
H
V
T
P
R
N
G
S
T
E
Site 5
S70
H
V
T
P
R
N
G
S
T
E
P
A
T
A
P
Site 6
T75
N
G
S
T
E
P
A
T
A
P
G
S
P
E
P
Site 7
S79
E
P
A
T
A
P
G
S
P
E
P
P
S
E
L
Site 8
S84
P
G
S
P
E
P
P
S
E
L
L
E
D
G
Q
Site 9
T93
L
L
E
D
G
Q
D
T
P
T
S
A
E
S
P
Site 10
T95
E
D
G
Q
D
T
P
T
S
A
E
S
P
D
A
Site 11
S96
D
G
Q
D
T
P
T
S
A
E
S
P
D
A
P
Site 12
S99
D
T
P
T
S
A
E
S
P
D
A
P
E
E
N
Site 13
S159
L
A
L
A
G
P
S
S
T
P
Q
E
N
G
T
Site 14
T160
A
L
A
G
P
S
S
T
P
Q
E
N
G
T
T
Site 15
T167
T
P
Q
E
N
G
T
T
L
W
P
S
R
G
I
Site 16
S171
N
G
T
T
L
W
P
S
R
G
I
P
S
S
P
Site 17
S177
P
S
R
G
I
P
S
S
P
G
A
H
T
T
E
Site 18
T183
S
S
P
G
A
H
T
T
E
A
G
T
L
P
A
Site 19
T192
A
G
T
L
P
A
P
T
P
S
P
P
S
L
G
Site 20
S194
T
L
P
A
P
T
P
S
P
P
S
L
G
R
P
Site 21
S197
A
P
T
P
S
P
P
S
L
G
R
P
W
A
P
Site 22
T206
G
R
P
W
A
P
L
T
G
P
S
V
P
P
P
Site 23
S209
W
A
P
L
T
G
P
S
V
P
P
P
S
S
G
Site 24
S214
G
P
S
V
P
P
P
S
S
G
R
A
S
L
S
Site 25
S215
P
S
V
P
P
P
S
S
G
R
A
S
L
S
S
Site 26
S219
P
P
S
S
G
R
A
S
L
S
S
L
L
G
G
Site 27
S221
S
S
G
R
A
S
L
S
S
L
L
G
G
A
P
Site 28
S222
S
G
R
A
S
L
S
S
L
L
G
G
A
P
P
Site 29
S232
G
G
A
P
P
W
G
S
L
Q
D
P
D
S
Q
Site 30
S238
G
S
L
Q
D
P
D
S
Q
G
L
S
P
A
A
Site 31
S242
D
P
D
S
Q
G
L
S
P
A
A
A
A
P
S
Site 32
S249
S
P
A
A
A
A
P
S
Q
Q
L
Q
R
P
D
Site 33
T261
R
P
D
V
R
L
R
T
P
L
L
H
P
L
V
Site 34
S279
L
G
K
H
A
A
P
S
A
F
S
S
G
L
P
Site 35
S301
V
T
T
L
T
R
D
S
G
A
W
V
S
H
V
Site 36
S306
R
D
S
G
A
W
V
S
H
V
A
N
S
V
G
Site 37
S421
A
L
Q
D
A
C
W
S
R
L
G
G
G
R
L
Site 38
S454
G
P
A
A
E
R
I
S
E
E
V
G
L
L
Q
Site 39
T474
P
P
Q
Q
V
T
Q
T
D
D
P
D
V
G
L
Site 40
Y483
D
P
D
V
G
L
A
Y
V
F
G
P
D
A
N
Site 41
Y497
N
S
G
Q
V
A
R
Y
H
F
P
S
L
F
F
Site 42
S501
V
A
R
Y
H
F
P
S
L
F
F
R
D
F
S
Site 43
S551
Q
D
G
H
Q
D
I
S
L
L
Y
T
E
P
G
Site 44
Y554
H
Q
D
I
S
L
L
Y
T
E
P
G
A
G
Q
Site 45
T555
Q
D
I
S
L
L
Y
T
E
P
G
A
G
Q
T
Site 46
T564
P
G
A
G
Q
T
H
T
A
A
S
F
R
L
P
Site 47
S606
Q
R
M
P
L
A
R
S
S
R
G
L
E
L
E
Site 48
S607
R
M
P
L
A
R
S
S
R
G
L
E
L
E
P
Site 49
S647
V
R
R
D
P
Q
V
S
P
M
H
C
L
D
E
Site 50
S659
L
D
E
E
G
D
D
S
D
G
A
S
G
D
S
Site 51
S663
G
D
D
S
D
G
A
S
G
D
S
G
S
G
L
Site 52
S666
S
D
G
A
S
G
D
S
G
S
G
L
G
D
A
Site 53
S668
G
A
S
G
D
S
G
S
G
L
G
D
A
R
E
Site 54
T681
R
E
L
L
R
E
E
T
G
A
A
L
K
P
R
Site 55
T697
P
A
P
P
P
V
T
T
P
P
L
A
G
G
S
Site 56
S705
P
P
L
A
G
G
S
S
T
E
D
S
R
S
E
Site 57
S709
G
G
S
S
T
E
D
S
R
S
E
E
V
E
E
Site 58
S711
S
S
T
E
D
S
R
S
E
E
V
E
E
Q
T
Site 59
T718
S
E
E
V
E
E
Q
T
T
V
A
S
L
G
A
Site 60
T719
E
E
V
E
E
Q
T
T
V
A
S
L
G
A
Q
Site 61
S731
G
A
Q
T
L
P
G
S
D
S
V
S
T
W
D
Site 62
S733
Q
T
L
P
G
S
D
S
V
S
T
W
D
G
S
Site 63
S735
L
P
G
S
D
S
V
S
T
W
D
G
S
V
R
Site 64
T736
P
G
S
D
S
V
S
T
W
D
G
S
V
R
T
Site 65
S740
S
V
S
T
W
D
G
S
V
R
T
P
G
G
R
Site 66
T743
T
W
D
G
S
V
R
T
P
G
G
R
V
K
E
Site 67
S774
G
R
A
G
P
P
G
S
P
C
L
P
G
P
P
Site 68
T799
P
A
G
P
A
L
Q
T
V
P
G
P
Q
G
P
Site 69
T815
G
P
P
G
R
D
G
T
P
G
R
D
G
E
P
Site 70
T834
E
D
G
K
P
G
D
T
G
P
Q
G
F
P
G
Site 71
T842
G
P
Q
G
F
P
G
T
P
G
D
V
G
P
K
Site 72
S875
P
P
G
P
P
G
P
S
F
R
H
D
K
L
T
Site 73
T882
S
F
R
H
D
K
L
T
F
I
D
M
E
G
S
Site 74
S927
P
G
R
F
G
V
N
S
S
D
V
P
G
P
A
Site 75
S928
G
R
F
G
V
N
S
S
D
V
P
G
P
A
G
Site 76
S972
G
R
T
G
Q
K
G
S
L
G
E
A
G
A
P
Site 77
S997
P
A
G
A
R
G
E
S
G
L
A
G
A
P
G
Site 78
S1032
G
F
D
D
M
E
G
S
G
G
P
F
W
S
T
Site 79
S1038
G
S
G
G
P
F
W
S
T
A
R
S
A
D
G
Site 80
T1039
S
G
G
P
F
W
S
T
A
R
S
A
D
G
P
Site 81
S1042
P
F
W
S
T
A
R
S
A
D
G
P
Q
G
P
Site 82
S1100
G
P
K
G
D
R
G
S
R
G
E
K
G
D
P
Site 83
Y1129
G
P
P
G
P
V
V
Y
V
S
E
Q
D
G
S
Site 84
S1136
Y
V
S
E
Q
D
G
S
V
L
S
V
P
G
P
Site 85
S1139
E
Q
D
G
S
V
L
S
V
P
G
P
E
G
R
Site 86
S1164
G
P
K
G
N
L
G
S
K
G
E
R
G
S
P
Site 87
S1170
G
S
K
G
E
R
G
S
P
G
P
K
G
E
K
Site 88
S1182
G
E
K
G
E
P
G
S
I
F
S
P
D
G
G
Site 89
S1185
G
E
P
G
S
I
F
S
P
D
G
G
A
L
G
Site 90
Y1211
F
R
G
P
P
G
P
Y
G
R
P
G
Y
K
G
Site 91
Y1216
G
P
Y
G
R
P
G
Y
K
G
E
I
G
F
P
Site 92
S1245
K
G
E
P
G
D
A
S
L
G
F
G
M
R
G
Site 93
T1268
G
P
P
G
P
P
G
T
P
V
Y
D
S
N
V
Site 94
Y1271
G
P
P
G
T
P
V
Y
D
S
N
V
F
A
E
Site 95
S1273
P
G
T
P
V
Y
D
S
N
V
F
A
E
S
S
Site 96
S1279
D
S
N
V
F
A
E
S
S
R
P
G
P
P
G
Site 97
S1280
S
N
V
F
A
E
S
S
R
P
G
P
P
G
L
Site 98
S1350
G
G
G
G
F
F
G
S
S
L
P
G
P
P
G
Site 99
S1351
G
G
G
F
F
G
S
S
L
P
G
P
P
G
P
Site 100
Y1367
G
P
P
G
P
R
G
Y
P
G
I
P
G
P
K
Site 101
S1377
I
P
G
P
K
G
E
S
I
R
G
Q
P
G
P
Site 102
Y1395
Q
G
P
P
G
I
G
Y
E
G
R
Q
G
P
P
Site 103
S1412
P
G
P
P
G
P
P
S
F
P
G
P
H
R
Q
Site 104
T1420
F
P
G
P
H
R
Q
T
I
S
V
P
G
P
P
Site 105
S1422
G
P
H
R
Q
T
I
S
V
P
G
P
P
G
P
Site 106
T1438
G
P
P
G
P
P
G
T
M
G
A
S
S
G
V
Site 107
S1442
P
P
G
T
M
G
A
S
S
G
V
R
L
W
A
Site 108
T1450
S
G
V
R
L
W
A
T
R
Q
A
M
L
G
Q
Site 109
Y1476
V
A
E
Q
E
E
L
Y
V
R
V
Q
N
G
F
Site 110
T1492
K
V
Q
L
E
A
R
T
P
L
P
R
G
T
D
Site 111
T1498
R
T
P
L
P
R
G
T
D
N
E
V
A
A
L
Site 112
S1515
P
V
V
Q
L
H
D
S
N
P
Y
P
R
R
E
Site 113
Y1518
Q
L
H
D
S
N
P
Y
P
R
R
E
H
P
H
Site 114
T1527
R
R
E
H
P
H
P
T
A
R
P
W
R
A
D
Site 115
S1539
R
A
D
D
I
L
A
S
P
P
R
L
P
E
P
Site 116
Y1549
R
L
P
E
P
Q
P
Y
P
G
A
P
H
H
S
Site 117
Y1558
G
A
P
H
H
S
S
Y
V
H
L
R
P
A
R
Site 118
T1567
H
L
R
P
A
R
P
T
S
P
P
A
H
S
H
Site 119
S1568
L
R
P
A
R
P
T
S
P
P
A
H
S
H
R
Site 120
S1573
P
T
S
P
P
A
H
S
H
R
D
F
Q
P
V
Site 121
S1622
G
T
F
R
A
F
L
S
S
R
L
Q
D
L
Y
Site 122
S1623
T
F
R
A
F
L
S
S
R
L
Q
D
L
Y
S
Site 123
Y1629
S
S
R
L
Q
D
L
Y
S
I
V
R
R
A
D
Site 124
S1630
S
R
L
Q
D
L
Y
S
I
V
R
R
A
D
R
Site 125
S1659
P
S
W
E
A
L
F
S
G
S
E
G
P
L
K
Site 126
S1661
W
E
A
L
F
S
G
S
E
G
P
L
K
P
G
Site 127
S1673
K
P
G
A
R
I
F
S
F
D
G
K
D
V
L
Site 128
T1684
K
D
V
L
R
H
P
T
W
P
Q
K
S
V
W
Site 129
S1694
Q
K
S
V
W
H
G
S
D
P
N
G
R
R
L
Site 130
T1702
D
P
N
G
R
R
L
T
E
S
Y
C
E
T
W
Site 131
S1704
N
G
R
R
L
T
E
S
Y
C
E
T
W
R
T
Site 132
Y1705
G
R
R
L
T
E
S
Y
C
E
T
W
R
T
E
Site 133
T1708
L
T
E
S
Y
C
E
T
W
R
T
E
A
P
S
Site 134
T1711
S
Y
C
E
T
W
R
T
E
A
P
S
A
T
G
Site 135
S1715
T
W
R
T
E
A
P
S
A
T
G
Q
A
S
S
Site 136
S1732
G
G
R
L
L
G
Q
S
A
A
S
C
H
H
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation