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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MMP12
Full Name:
Macrophage metalloelastase
Alias:
HME; macrophage elastase; macrophage metalloelastase; matrix metallopeptidase 12; matrix metalloproteinase-12; ME; MME; MMP-12
Type:
EC 3.4.24.65; Protease
Mass (Da):
54002
Number AA:
470
UniProt ID:
P39900
International Prot ID:
IPI00298246
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
S
G
A
L
P
L
N
S
S
T
S
L
E
K
N
Site 2
S22
G
A
L
P
L
N
S
S
T
S
L
E
K
N
N
Site 3
S24
L
P
L
N
S
S
T
S
L
E
K
N
N
V
L
Site 4
Y36
N
V
L
F
G
E
R
Y
L
E
K
F
Y
G
L
Site 5
T51
E
I
N
K
L
P
V
T
K
M
K
Y
S
G
N
Site 6
S82
V
T
G
Q
L
D
T
S
T
L
E
M
M
H
A
Site 7
T83
T
G
Q
L
D
T
S
T
L
E
M
M
H
A
P
Site 8
Y113
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Site 9
Y116
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
Site 10
Y121
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
Site 11
T122
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
Site 12
Y132
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
Site 13
S189
A
H
A
F
G
P
G
S
G
I
G
G
D
A
H
Site 14
T205
D
E
D
E
F
W
T
T
H
S
G
G
T
N
L
Site 15
S223
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
Site 16
S229
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
Site 17
S230
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
Site 18
Y240
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
Site 19
Y242
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
Site 20
T247
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
Site 21
S251
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Site 22
S260
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
Site 23
Y262
I
R
G
I
Q
S
L
Y
G
D
P
K
E
N
Q
Site 24
S277
R
L
P
N
P
D
N
S
E
P
A
L
C
D
P
Site 25
S311
R
F
F
W
L
K
V
S
E
R
P
K
T
S
V
Site 26
T316
K
V
S
E
R
P
K
T
S
V
N
L
I
S
S
Site 27
S317
V
S
E
R
P
K
T
S
V
N
L
I
S
S
L
Site 28
Y352
F
L
F
K
D
D
K
Y
W
L
I
S
N
L
R
Site 29
Y364
N
L
R
P
E
P
N
Y
P
K
S
I
H
S
F
Site 30
S367
P
E
P
N
Y
P
K
S
I
H
S
F
G
F
P
Site 31
Y390
A
V
F
N
P
R
F
Y
R
T
Y
F
F
V
D
Site 32
Y393
N
P
R
F
Y
R
T
Y
F
F
V
D
N
Q
Y
Site 33
Y400
Y
F
F
V
D
N
Q
Y
W
R
Y
D
E
R
R
Site 34
Y414
R
Q
M
M
D
P
G
Y
P
K
L
I
T
K
N
Site 35
T419
P
G
Y
P
K
L
I
T
K
N
F
Q
G
I
G
Site 36
Y434
P
K
I
D
A
V
F
Y
S
K
N
K
Y
Y
Y
Site 37
Y439
V
F
Y
S
K
N
K
Y
Y
Y
F
F
Q
G
S
Site 38
Y440
F
Y
S
K
N
K
Y
Y
Y
F
F
Q
G
S
N
Site 39
Y441
Y
S
K
N
K
Y
Y
Y
F
F
Q
G
S
N
Q
Site 40
Y451
Q
G
S
N
Q
F
E
Y
D
F
L
L
Q
R
I
Site 41
T459
D
F
L
L
Q
R
I
T
K
T
L
K
S
N
S
Site 42
T461
L
L
Q
R
I
T
K
T
L
K
S
N
S
W
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation