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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DCT
Full Name:
L-dopachrome tautomerase
Alias:
Dct; Dopachrome delta-isomerase, tyrosine-related protein 2; Dopachrome tautomerase; Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); L-dopachrome Delta-isomerase; Tyrosinase-related protein 2; Tyrp2
Type:
EC 5.3.3.12; Amino Acid Metabolism - tyrosine; Cell development/differentiation; Isomerase
Mass (Da):
59127
Number AA:
519
UniProt ID:
P40126
International Prot ID:
IPI00027343
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016021
GO:0042470
Uniprot
OncoNet
Molecular Function:
GO:0005507
GO:0004167
GO:0016491
PhosphoSite+
KinaseNET
Biological Process:
GO:0008544
GO:0006583
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S48
C
P
R
L
G
A
E
S
A
N
V
C
G
S
Q
Site 2
S54
E
S
A
N
V
C
G
S
Q
Q
G
R
G
Q
C
Site 3
T68
C
T
E
V
R
A
D
T
R
P
W
S
G
P
Y
Site 4
S72
R
A
D
T
R
P
W
S
G
P
Y
I
L
R
N
Site 5
S132
V
I
R
Q
N
I
H
S
L
S
P
Q
E
R
E
Site 6
S134
R
Q
N
I
H
S
L
S
P
Q
E
R
E
Q
F
Site 7
Y156
K
K
R
V
H
P
D
Y
V
I
T
T
Q
H
W
Site 8
T172
G
L
L
G
P
N
G
T
Q
P
Q
F
A
N
C
Site 9
T196
H
Y
Y
S
V
R
D
T
L
L
G
P
G
R
P
Site 10
Y204
L
L
G
P
G
R
P
Y
R
A
I
D
F
S
H
Site 11
S210
P
Y
R
A
I
D
F
S
H
Q
G
P
A
F
V
Site 12
Y244
N
E
S
F
A
L
P
Y
W
N
F
A
T
G
R
Site 13
T271
A
A
R
P
D
D
P
T
L
I
S
R
N
S
R
Site 14
S274
P
D
D
P
T
L
I
S
R
N
S
R
F
S
S
Site 15
S277
P
T
L
I
S
R
N
S
R
F
S
S
W
E
T
Site 16
S280
I
S
R
N
S
R
F
S
S
W
E
T
V
C
D
Site 17
S281
S
R
N
S
R
F
S
S
W
E
T
V
C
D
S
Site 18
T284
S
R
F
S
S
W
E
T
V
C
D
S
L
D
D
Site 19
S316
R
N
Q
M
G
R
N
S
M
K
L
P
T
L
K
Site 20
S330
K
D
I
R
D
C
L
S
L
Q
K
F
D
N
P
Site 21
S343
N
P
P
F
F
Q
N
S
T
F
S
F
R
N
A
Site 22
T344
P
P
F
F
Q
N
S
T
F
S
F
R
N
A
L
Site 23
S346
F
F
Q
N
S
T
F
S
F
R
N
A
L
E
G
Site 24
T360
G
F
D
K
A
D
G
T
L
D
S
Q
V
M
S
Site 25
S363
K
A
D
G
T
L
D
S
Q
V
M
S
L
H
N
Site 26
S367
T
L
D
S
Q
V
M
S
L
H
N
L
V
H
S
Site 27
S374
S
L
H
N
L
V
H
S
F
L
N
G
T
N
A
Site 28
S385
G
T
N
A
L
P
H
S
A
A
N
D
P
I
F
Site 29
T447
T
N
E
E
L
F
L
T
S
D
Q
L
G
Y
S
Site 30
S454
T
S
D
Q
L
G
Y
S
Y
A
I
D
L
P
V
Site 31
S462
Y
A
I
D
L
P
V
S
V
E
E
T
P
G
W
Site 32
T466
L
P
V
S
V
E
E
T
P
G
W
P
T
T
L
Site 33
Y495
V
L
L
A
F
L
Q
Y
R
R
L
R
K
G
Y
Site 34
Y502
Y
R
R
L
R
K
G
Y
T
P
L
M
E
T
H
Site 35
T503
R
R
L
R
K
G
Y
T
P
L
M
E
T
H
L
Site 36
T508
G
Y
T
P
L
M
E
T
H
L
S
S
K
R
Y
Site 37
S511
P
L
M
E
T
H
L
S
S
K
R
Y
T
E
E
Site 38
S512
L
M
E
T
H
L
S
S
K
R
Y
T
E
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation