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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADCY8
Full Name:
Adenylate cyclase type 8
Alias:
ADCY3; Adenylate cyclase 8; Adenylate cyclase type VIII; Adenylyl cyclase-8, brain; ATP pyrophosphate-lyase 8; Brain adenylate cyclase 8; EC 4.6.1.1; HBAC1
Type:
Membrane fraction, Plasma membrane, Integral membrane protein
Mass (Da):
140122
Number AA:
1251
UniProt ID:
P40145
International Prot ID:
IPI00027356
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005624
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008294
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007189
GO:0034199
GO:0006171
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
E
L
S
D
V
R
C
L
T
G
Site 2
T10
L
S
D
V
R
C
L
T
G
S
E
E
L
Y
T
Site 3
S12
D
V
R
C
L
T
G
S
E
E
L
Y
T
I
H
Site 4
Y16
L
T
G
S
E
E
L
Y
T
I
H
P
T
P
P
Site 5
T17
T
G
S
E
E
L
Y
T
I
H
P
T
P
P
A
Site 6
T21
E
L
Y
T
I
H
P
T
P
P
A
G
D
G
R
Site 7
S29
P
P
A
G
D
G
R
S
A
S
R
P
Q
R
L
Site 8
S31
A
G
D
G
R
S
A
S
R
P
Q
R
L
L
W
Site 9
T40
P
Q
R
L
L
W
Q
T
A
V
R
H
I
T
E
Site 10
T46
Q
T
A
V
R
H
I
T
E
Q
R
F
I
H
G
Site 11
S58
I
H
G
H
R
G
G
S
G
S
G
S
G
G
S
Site 12
S60
G
H
R
G
G
S
G
S
G
S
G
G
S
G
K
Site 13
S62
R
G
G
S
G
S
G
S
G
G
S
G
K
A
S
Site 14
S65
S
G
S
G
S
G
G
S
G
K
A
S
D
P
A
Site 15
S69
S
G
G
S
G
K
A
S
D
P
A
G
G
G
P
Site 16
S84
N
H
H
A
P
Q
L
S
G
D
S
A
L
P
L
Site 17
Y92
G
D
S
A
L
P
L
Y
S
L
G
P
G
E
R
Site 18
S93
D
S
A
L
P
L
Y
S
L
G
P
G
E
R
A
Site 19
S102
G
P
G
E
R
A
H
S
T
C
G
T
K
V
F
Site 20
T106
R
A
H
S
T
C
G
T
K
V
F
P
E
R
S
Site 21
S113
T
K
V
F
P
E
R
S
G
S
G
S
A
S
G
Site 22
S115
V
F
P
E
R
S
G
S
G
S
A
S
G
S
G
Site 23
S117
P
E
R
S
G
S
G
S
A
S
G
S
G
G
G
Site 24
S119
R
S
G
S
G
S
A
S
G
S
G
G
G
G
D
Site 25
S121
G
S
G
S
A
S
G
S
G
G
G
G
D
L
G
Site 26
S137
L
H
L
D
C
A
P
S
N
S
D
F
F
L
N
Site 27
S139
L
D
C
A
P
S
N
S
D
F
F
L
N
G
G
Site 28
T156
Y
R
G
V
I
F
P
T
L
R
N
S
F
K
S
Site 29
S160
I
F
P
T
L
R
N
S
F
K
S
R
D
L
E
Site 30
S163
T
L
R
N
S
F
K
S
R
D
L
E
R
L
Y
Site 31
Y170
S
R
D
L
E
R
L
Y
Q
R
Y
F
L
G
Q
Site 32
Y173
L
E
R
L
Y
Q
R
Y
F
L
G
Q
R
R
K
Site 33
S181
F
L
G
Q
R
R
K
S
E
V
V
M
N
V
L
Site 34
T236
L
V
V
V
R
K
D
T
T
S
H
T
Y
L
Q
Site 35
T237
V
V
V
R
K
D
T
T
S
H
T
Y
L
Q
Y
Site 36
S238
V
V
R
K
D
T
T
S
H
T
Y
L
Q
Y
S
Site 37
T240
R
K
D
T
T
S
H
T
Y
L
Q
Y
S
G
V
Site 38
Y241
K
D
T
T
S
H
T
Y
L
Q
Y
S
G
V
V
Site 39
S339
N
T
A
G
I
F
I
S
Y
L
S
D
R
A
Q
Site 40
Y340
T
A
G
I
F
I
S
Y
L
S
D
R
A
Q
R
Site 41
S342
G
I
F
I
S
Y
L
S
D
R
A
Q
R
Q
A
Site 42
T365
E
A
R
L
R
L
E
T
E
N
Q
R
Q
E
R
Site 43
Y406
Q
H
Q
F
H
R
I
Y
I
H
R
Y
E
N
V
Site 44
Y410
H
R
I
Y
I
H
R
Y
E
N
V
S
I
L
F
Site 45
S427
V
K
G
F
T
N
L
S
T
T
L
S
A
Q
E
Site 46
S431
T
N
L
S
T
T
L
S
A
Q
E
L
V
R
M
Site 47
T492
M
G
L
S
M
I
K
T
I
R
Y
V
R
S
R
Site 48
Y495
S
M
I
K
T
I
R
Y
V
R
S
R
T
K
H
Site 49
T500
I
R
Y
V
R
S
R
T
K
H
D
V
D
M
R
Site 50
Y563
L
D
C
L
N
G
D
Y
N
V
E
E
G
H
G
Site 51
Y585
R
K
H
N
I
E
T
Y
L
I
K
Q
P
E
D
Site 52
S593
L
I
K
Q
P
E
D
S
L
L
S
L
P
E
D
Site 53
S596
Q
P
E
D
S
L
L
S
L
P
E
D
I
V
K
Site 54
S605
P
E
D
I
V
K
E
S
V
S
S
S
D
R
R
Site 55
S607
D
I
V
K
E
S
V
S
S
S
D
R
R
N
S
Site 56
S608
I
V
K
E
S
V
S
S
S
D
R
R
N
S
G
Site 57
S609
V
K
E
S
V
S
S
S
D
R
R
N
S
G
A
Site 58
S614
S
S
S
D
R
R
N
S
G
A
T
F
T
E
G
Site 59
T617
D
R
R
N
S
G
A
T
F
T
E
G
S
W
S
Site 60
S622
G
A
T
F
T
E
G
S
W
S
P
E
L
P
F
Site 61
S624
T
F
T
E
G
S
W
S
P
E
L
P
F
D
N
Site 62
S692
R
E
H
I
K
P
F
S
L
M
F
K
D
S
S
Site 63
S698
F
S
L
M
F
K
D
S
S
L
E
H
K
Y
S
Site 64
S699
S
L
M
F
K
D
S
S
L
E
H
K
Y
S
Q
Site 65
S705
S
S
L
E
H
K
Y
S
Q
M
R
D
E
V
F
Site 66
T827
F
N
S
S
A
V
F
T
D
I
C
S
Y
P
E
Site 67
S890
R
Y
D
N
L
N
H
S
G
E
D
F
L
G
T
Site 68
T922
H
G
Q
Q
L
E
Y
T
A
R
L
D
F
L
W
Site 69
Y974
D
R
D
N
E
E
L
Y
S
Q
S
Y
D
A
V
Site 70
S975
R
D
N
E
E
L
Y
S
Q
S
Y
D
A
V
G
Site 71
S977
N
E
E
L
Y
S
Q
S
Y
D
A
V
G
V
M
Site 72
Y978
E
E
L
Y
S
Q
S
Y
D
A
V
G
V
M
F
Site 73
Y995
I
P
G
F
A
D
F
Y
S
Q
T
E
M
N
N
Site 74
T1035
Q
D
I
E
K
I
K
T
I
G
S
T
Y
M
A
Site 75
S1038
E
K
I
K
T
I
G
S
T
Y
M
A
V
S
G
Site 76
S1047
Y
M
A
V
S
G
L
S
P
E
K
Q
Q
C
E
Site 77
S1073
F
S
L
A
L
T
E
S
I
Q
E
I
N
K
H
Site 78
Y1108
I
G
A
K
K
P
Q
Y
D
I
W
G
K
T
V
Site 79
S1119
G
K
T
V
N
L
A
S
R
M
D
S
T
G
V
Site 80
S1123
N
L
A
S
R
M
D
S
T
G
V
S
G
R
I
Site 81
T1124
L
A
S
R
M
D
S
T
G
V
S
G
R
I
Q
Site 82
S1127
R
M
D
S
T
G
V
S
G
R
I
Q
V
P
E
Site 83
Y1149
D
Q
G
F
A
F
D
Y
R
G
E
I
Y
V
K
Site 84
Y1154
F
D
Y
R
G
E
I
Y
V
K
G
I
S
E
Q
Site 85
S1159
E
I
Y
V
K
G
I
S
E
Q
E
G
K
I
K
Site 86
Y1168
Q
E
G
K
I
K
T
Y
F
L
L
G
R
V
Q
Site 87
S1202
V
V
L
G
L
V
Q
S
L
N
R
Q
R
Q
K
Site 88
T1218
L
L
N
E
N
N
N
T
G
I
I
K
G
H
Y
Site 89
Y1225
T
G
I
I
K
G
H
Y
N
R
R
T
L
L
S
Site 90
T1229
K
G
H
Y
N
R
R
T
L
L
S
P
S
G
T
Site 91
S1232
Y
N
R
R
T
L
L
S
P
S
G
T
E
P
G
Site 92
S1234
R
R
T
L
L
S
P
S
G
T
E
P
G
A
Q
Site 93
T1236
T
L
L
S
P
S
G
T
E
P
G
A
Q
A
E
Site 94
T1245
P
G
A
Q
A
E
G
T
D
K
S
D
L
P
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation