PhosphoNET

           
Protein Info 
   
Short Name:  IL6ST
Full Name:  Interleukin-6 receptor subunit beta
Alias:  CD130; CDw130; GP130; Gp130, oncostatin M receptor; IL6B; IL6RB; IL-6R-beta; Interleukin 6 signal transducer; Interleukin-6 receptor beta chain precursor; Membrane glycoprotein 130; Oncostatin M receptor
Type:  Receptor, cytokine
Mass (Da):  103537
Number AA:  918
UniProt ID:  P40189
International Prot ID:  IPI00297124
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0070110  GO:0005576  GO:0005615 Uniprot OncoNet
Molecular Function:  GO:0004897  GO:0005127  GO:0045509 PhosphoSite+ KinaseNET
Biological Process:  GO:0070120  GO:0070106  GO:0048861 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S233HNLSVINSEELSSIL
Site 2S237VINSEELSSILKLTW
Site 3S238INSEELSSILKLTWT
Site 4Y309MKEDGKGYWSDWSEE
Site 5Y322EEASGITYEDRPSKA
Site 6Y396VNLTNDRYLATLTVR
Site 7S661NVPDPSKSHIAQWSP
Site 8S667KSHIAQWSPHTPPRH
Site 9T670IAQWSPHTPPRHNFN
Site 10S678PPRHNFNSKDQMYSD
Site 11Y683FNSKDQMYSDGNFTD
Site 12S684NSKDQMYSDGNFTDV
Site 13S692DGNFTDVSVVEIEAN
Site 14S710PFPEDLKSLDLFKKE
Site 15T721FKKEKINTEGHSSGI
Site 16S725KINTEGHSSGIGGSS
Site 17S726INTEGHSSGIGGSSC
Site 18S731HSSGIGGSSCMSSSR
Site 19S732SSGIGGSSCMSSSRP
Site 20S735IGGSSCMSSSRPSIS
Site 21S736GGSSCMSSSRPSISS
Site 22S737GSSCMSSSRPSISSS
Site 23S740CMSSSRPSISSSDEN
Site 24S742SSSRPSISSSDENES
Site 25S743SSRPSISSSDENESS
Site 26S744SRPSISSSDENESSQ
Site 27S749SSSDENESSQNTSST
Site 28S750SSDENESSQNTSSTV
Site 29T753ENESSQNTSSTVQYS
Site 30S754NESSQNTSSTVQYST
Site 31S755ESSQNTSSTVQYSTV
Site 32T756SSQNTSSTVQYSTVV
Site 33Y759NTSSTVQYSTVVHSG
Site 34S760TSSTVQYSTVVHSGY
Site 35T761SSTVQYSTVVHSGYR
Site 36Y767STVVHSGYRHQVPSV
Site 37S773GYRHQVPSVQVFSRS
Site 38S778VPSVQVFSRSESTQP
Site 39S780SVQVFSRSESTQPLL
Site 40S782QVFSRSESTQPLLDS
Site 41T783VFSRSESTQPLLDSE
Site 42S789STQPLLDSEERPEDL
Site 43Y814GILPRQQYFKQNCSQ
Site 44S820QYFKQNCSQHESSPD
Site 45S824QNCSQHESSPDISHF
Site 46S825NCSQHESSPDISHFE
Site 47S829HESSPDISHFERSKQ
Site 48S834DISHFERSKQVSSVN
Site 49S838FERSKQVSSVNEEDF
Site 50S839ERSKQVSSVNEEDFV
Site 51S853VRLKQQISDHISQSC
Site 52S857QQISDHISQSCGSGQ
Site 53S859ISDHISQSCGSGQMK
Site 54T890GQVERFETVGMEAAT
Site 55T897TVGMEAATDEGMPKS
Site 56S904TDEGMPKSYLPQTVR
Site 57Y905DEGMPKSYLPQTVRQ
Site 58T909PKSYLPQTVRQGGYM
Site 59Y915QTVRQGGYMPQ____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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