PhosphoNET

           
Protein Info 
   
Short Name:  THPO
Full Name:  Thrombopoietin
Alias:  C-mpl ligand;Megakaryocyte colony-stimulating factor;Megakaryocyte growth and development factor;Myeloproliferative leukemia virus oncogene ligand
Type: 
Mass (Da):  37823
Number AA:  353
UniProt ID:  P40225
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S22TARLTLSSPAPPACD
Site 2S34ACDLRVLSKLLRDSH
Site 3S40LSKLLRDSHVLHSRL
Site 4S48HVLHSRLSQCPEVHP
Site 5T58PEVHPLPTPVLLPAV
Site 6S68LLPAVDFSLGEWKTQ
Site 7T74FSLGEWKTQMEETKA
Site 8T79WKTQMEETKAQDILG
Site 9T131ALQSLLGTQLPPQGR
Site 10T140LPPQGRTTAHKDPNA
Site 11T179CVRRAPPTTAVPSRT
Site 12T180VRRAPPTTAVPSRTS
Site 13S184PPTTAVPSRTSLVLT
Site 14T191SRTSLVLTLNELPNR
Site 15S200NELPNRTSGLLETNF
Site 16T205RTSGLLETNFTASAR
Site 17T208GLLETNFTASARTTG
Site 18S210LETNFTASARTTGSG
Site 19T214FTASARTTGSGLLKW
Site 20S216ASARTTGSGLLKWQQ
Site 21S237PGLLNQTSRSLDQIP
Site 22S239LLNQTSRSLDQIPGY
Site 23Y246SLDQIPGYLNRIHEL
Site 24S265RGLFPGPSRRTLGAP
Site 25T268FPGPSRRTLGAPDIS
Site 26S276LGAPDISSGTSDTGS
Site 27S279PDISSGTSDTGSLPP
Site 28T281ISSGTSDTGSLPPNL
Site 29S283SGTSDTGSLPPNLQP
Site 30Y292PPNLQPGYSPSPTHP
Site 31S293PNLQPGYSPSPTHPP
Site 32S295LQPGYSPSPTHPPTG
Site 33T297PGYSPSPTHPPTGQY
Site 34T301PSPTHPPTGQYTLFP
Site 35T305HPPTGQYTLFPLPPT
Site 36S328HPLLPDPSAPTPTPT
Site 37T331LPDPSAPTPTPTSPL
Site 38T333DPSAPTPTPTSPLLN
Site 39S336APTPTPTSPLLNTSY
Site 40S342TSPLLNTSYTHSQNL
Site 41Y343SPLLNTSYTHSQNLS
Site 42T344PLLNTSYTHSQNLSQ
Site 43S346LNTSYTHSQNLSQEG
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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