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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VHL
Full Name:
Von Hippel-Lindau disease tumor suppressor
Alias:
Protein G7;pVHL
Type:
Tumour suppressor protein
Mass (Da):
24153
Number AA:
213
UniProt ID:
P40337
International Prot ID:
IPI00027969
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005783
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0000902
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
E
E
D
G
G
E
E
S
G
A
E
E
S
G
P
Site 2
S38
E
E
S
G
A
E
E
S
G
P
E
E
S
G
P
Site 3
S43
E
E
S
G
P
E
E
S
G
P
E
E
L
G
A
Site 4
S65
R
P
R
P
V
L
R
S
V
N
S
R
E
P
S
Site 5
S68
P
V
L
R
S
V
N
S
R
E
P
S
Q
V
I
Site 6
S72
S
V
N
S
R
E
P
S
Q
V
I
F
C
N
R
Site 7
Y98
F
D
G
E
P
Q
P
Y
P
T
L
P
P
G
T
Site 8
T100
G
E
P
Q
P
Y
P
T
L
P
P
G
T
G
R
Site 9
T105
Y
P
T
L
P
P
G
T
G
R
R
I
H
S
Y
Site 10
S111
G
T
G
R
R
I
H
S
Y
R
G
H
L
W
L
Site 11
Y112
T
G
R
R
I
H
S
Y
R
G
H
L
W
L
F
Site 12
S168
R
C
L
Q
V
V
R
S
L
V
K
P
E
N
Y
Site 13
Y175
S
L
V
K
P
E
N
Y
R
R
L
D
I
V
R
Site 14
S183
R
R
L
D
I
V
R
S
L
Y
E
D
L
E
D
Site 15
Y185
L
D
I
V
R
S
L
Y
E
D
L
E
D
H
P
Site 16
T202
Q
K
D
L
E
R
L
T
Q
E
R
I
A
H
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation